Protein Alignment Pkd2 and Pkd1l1

DIOPT Version :8

• Sequence 1: NP_609561.2
• Gene: Pkd2 / 34651
• FlyBaseID: FBgn0041195
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: XP_017460355.1
• Gene: Pkd1l1 / 289796
• RGDID: 1564724
• Length: 2771
• Species: Rattus norvegicus
• Alignment Length: 965
• Identity: 174/966 (18%)
• Similarity: 304/966 (31%)
• Gaps: 312/966 (32%)

  Fly    70 PPPATDPTGPPPT---AGKPVRDTGPSTS-----------------PRPSLRDPGQSTSDKPSTS 114
            ||...||.|.|.:   :..|:.|..|.|.                 |..:.||...:..::...|
  Rat  1963 PPSGPDPGGKPDSRQPSPHPISDLLPGTDQAWRMTASNSGIVHSSFPLEACRDKHLALRERSHCS 2027

  Fly   115 DKPSTSDKPSTSARTTVREPGPSSSP-----SRPVSTRESGRIT-------------FQEA---- 157
              |.:|..||:.    ..|..|..|.     |..|:...||..:             |..|
  Rat  2028 --PPSSQAPSSG----FEELRPQQSRVCLLWSSSVAWAISGTASLACGLGTGFLGYKFVPAQCVW 2086

  Fly   158 ------------APSTSAKVVKLAASEPRPAKPPEKEGFS-------------LFKRKKKSVG-S 196
                        |..|...::.||||.....:..:.|.|:             |.:|.:..:. |
  Rat  2087 WLHLLLLSLVCCALITQPLMICLAASAFAWKRKHDSEFFTESLQDATKGLDLELEERSRTHIPLS 2151

  Fly   197 STPPSPSRGHRAPSIIAA------------------SALQNRAKTNRILYTTDEEVREALVEFSV 243
            ....||.....|..::||                  ..::.|.:..|::       :.||.:.::
  Rat  2152 PVSYSPDSAEEAERVLAARQRERHLRWAQTPSGPKFRVMRERLRRERLM-------QAALRDVTM 2209

  Fly   244 FIIFLILTSLVVLSVRHTYMFYFNDTMKKLFTNREMVVAPSVTVGFEKLITVPDWWDYLKYNFLV 308
            ..:.|:|...:.........:..|..:::.||.       :.......|.:..||||:.....|.
  Rat  2210 HSVMLLLLLFIAYGRFCPGEYSLNQAIRRAFTR-------NAHHSLGDLSSTEDWWDWTLSTLLD 2267

  Fly   309 TLHGDLTFMDDAQANLTSMPPEGSEQGSEQGSEQGSEQSPEEVVGEAPEEAPEMDRLQEDFKYNG 373
            .||.:            .||      .:..||:.|:
  Rat  2268 GLHPE------------RMP------ATAWGSQPGA----------------------------- 2285

  Fly   374 NPYIDLRGHRRAKRQSGVDGNSEDGSEDVSGNYLKDDSDSIQANMSFHHLEGRVFLYENLLLGPP 438
                                                             |.|:..     |:||.
  Rat  2286 -------------------------------------------------LGGQCH-----LIGPS 2296

  Fly   439 RLRQIRVRKESCYVNDAFIRYFNTCYA--AYSSGAEDRKPMHKGSPFRTMHDLD-----STPIWT 496
            .::|::|...:            .|.|  .:|...||..|||.       |.||     .||...
  Rat  2297 VIKQLKVSAGT------------ACVAPKPFSELVEDVLPMHS-------HALDLENRNVTPDDP 2342

  Fly   497 VLAFYRTGGYTVNLDYDKDRNVKIINDLKDIHWLDRGSRLCLVEFNLFNENTDIFQSIKLIAEIP 561
            .....:...||.:|...:......:..|:...|:|..:|...|.|.|:|..|.:|.|:.|.||..
  Rat  2343 KTCGVKKESYTHSLGRTRHEAHAALTALRASRWIDHSTRAVSVHFTLYNPPTRLFTSVTLGAEFL 2407

  Fly   562 PTGGVIPQAHLQTVKMYSFFTDRSM--LMTVIYIFWYIMVIYYTIYEITEIRKSGIKIYFCSMLN 624
            .|.|::..:.:::..:  |:.|.::  |:.:..:.:.::.:.:..:::.|:...||..|:.....
  Rat  2408 STRGLVSSSLIESFSI--FYRDSALQCLLMLSELLFLVLNMIHLCFQLWEMATKGILSYWRKPRQ 2470

  Fly   625 ILDCAILLGCYLALVYNIWH-SFKVMSLTARAHSDVTYQSLDV--LCFWNIIYVDMMAILAFLVW 686
            .|:.: ::|..||......| :....::|.:.|..:..:.:|:  :..||.....:..||.||..
  Rat  2471 WLELS-MVGVALAYCAASGHLTTLAENITDQFHKGLYQRFVDISLMVSWNQRARCLQGILLFLWM 2534

  Fly   687 IKIFKFISFNKTLVQFTTTLKRCSKDLAGFSLMFGIVFLAYAQLGLLLFGTKHPDFRNFITSILT 751
            :|.....|...|:..|:..  .|       ||:|.:  |....:|.||... |...|.|:....|
  Rat  2535 LKCVHLFSSLSTMAPFSAV--TC-------SLLFRV--LMPTLVGALLLAA-HSHLRWFLLYTST 2587

  Fly   752 MIR---------MIL-------GDFQYNLIEQANRVLGPIYFLTYILLVFFILLNMFLAIIMETY 800
            :.|         ::|       .|.|:|.:|..:|.:. .|:.|..||:..:...|..|..:..:
  Rat  2588 LSRGTSAEAFPGLLLQFPGRSQKDSQHNHLESDHRAVN-CYYGTLFLLLATLGFRMLRATSLTLF 2651

  Fly   801 NTVKGEITQGRSHLGSYIYRKLSGMLYWITHCGRKRRHHPQASETEDKDAEHDVGAAHDETHEIR 865
            ...|.      .|..|.:..|...:..|.......|.....:.|||
  Rat  2652 QDRKS------FHRKSLVTLKDVAVSMWHRLLTFLRLETTTSGETE------------------- 2691

  Fly   866 KNMTPAEQQYFKDIPQGENQDMVRLNNRVGLLEEILEKLINNMDDI-LKRVEKDY 919
               ...:..|:             |:....||:|:|.|:....|.: |..:||.:
  Rat  2692 ---VTTDHIYY-------------LDEFSSLLDELLMKIDGLSDSLELSILEKQW 2730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	89/429 (21%)
Pkd1l1	XP_017460355.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C122481254
eggNOG	1	0.900				E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830