DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkd2 and Pkd1l1

DIOPT Version :9

Sequence 1:	NP_609561.2	Gene:	Pkd2 / 34651	FlyBaseID:	FBgn0041195	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_038948500.1	Gene:	Pkd1l1 / 289796	RGDID:	1564724	Length:	2586	Species:	Rattus norvegicus

Alignment Length:	763	Identity:	136/763 - (17%)
Similarity:	246/763 - (32%)	Gaps:	230/763 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 GSSTPPS---------PSRGHRAPSIIAASALQNRAKTNRILYTTDEEVREALVEFSVFIIFLIL 250
            |:..||.         ..|..:.||......::.|.:..|::       :.||.:.::..:.|:|
  Rat  1975 GAPLPPQVLAARQRERHLRWAQTPSGPKFRVMRERLRRERLM-------QAALRDVTMHSVMLLL 2032

  Fly   251 TSLVVLSVRHTYMFYFNDTMKKLFTNREMVVAPSVTVGFEKLITVPDWWDYLKYNFLVTLHGDLT 315
            ...:.........:..|..:::.||.       :.......|.:..||||:.....|..||.:
  Rat  2033 LLFIAYGRFCPGEYSLNQAIRRAFTR-------NAHHSLGDLSSTEDWWDWTLSTLLDGLHPE-- 2088

  Fly   316 FMDDAQANLTSMPPEGSEQGSEQGSEQGSEQSPEEVVGEAPEEAPEMDRLQEDFKYNGNPYIDLR 380
                      .||      .:..||:.|:
  Rat  2089 ----------RMP------ATAWGSQPGA------------------------------------ 2101

  Fly   381 GHRRAKRQSGVDGNSEDGSEDVSGNYLKDDSDSIQANMSFHHLEGRVFLYENLLLGPPRLRQIRV 445
                                                      |.|:..     |:||..::|::|
  Rat  2102 ------------------------------------------LGGQCH-----LIGPSVIKQLKV 2119

  Fly   446 RKESCYVNDAFIRYFNTCYA--AYSSGAEDRKPMHKGSPFRTMHDLD-----STPIWTVLAFYRT 503
            ...:            .|.|  .:|...||..|||.       |.||     .||........:.
  Rat  2120 SAGT------------ACVAPKPFSELVEDVLPMHS-------HALDLENRNVTPDDPKTCGVKK 2165

  Fly   504 GGYTVNLDYDKDRNVKIINDLKDIHWLDRGSRLCLVEFNLFNENTDIFQSIKLIAEIPPTGGVIP 568
            ..||.:|...:......:..|:...|:|..:|...|.|.|:|..|.:|.|:.|.||...|.|::.
  Rat  2166 ESYTHSLGRTRHEAHAALTALRASRWIDHSTRAVSVHFTLYNPPTRLFTSVTLGAEFLSTRGLVS 2230

  Fly   569 QAHLQTVKMYSFFTDRSM--LMTVIYIFWYIMVIYYTIYEITEIRKSGIKIYFCSMLNILDCAIL 631
            .:.:::..:  |:.|.::  |:.:..:.:.::.:.:..:::.|:...||..|:......|:.: :
  Rat  2231 SSLIESFSI--FYRDSALQCLLMLSELLFLVLNMIHLCFQLWEMATKGILSYWRKPRQWLELS-M 2292

  Fly   632 LGCYLALVYNIWH-SFKVMSLTARAHSDVTYQSLDV--LCFWNIIYVDMMAILAFLVWIKIFKFI 693
            :|..||......| :....::|.:.|..:..:.:|:  :..||.....:..||.||..:|.....
  Rat  2293 VGVALAYCAASGHLTTLAENITDQFHKGLYQRFVDISLMVSWNQRARCLQGILLFLWMLKCVHLF 2357

  Fly   694 SFNKTLVQFTTTLKRCSKDLAGFSLMFGIVFLAYAQLGLLLFGTKHPDFRNFITSILTMIR---- 754
            |...|:..|:..:..|.   ..|||..         :|.||... |...|.|:....|:.|
  Rat  2358 SSLSTMAPFSAMMGHCP---GVFSLQL---------VGALLLAA-HSHLRWFLLYTSTLSRGTSA 2409

  Fly   755 -----MIL-------GDFQYNLIEQANRVLGPIYFLTYILLVFFILLNMFLAIIMETYNTVKGEI 807
                 ::|       .|.|:|.:|..:|.:. .|:.|..||:..:...|..|..:..:...|.
  Rat  2410 EAFPGLLLQFPGRSQKDSQHNHLESDHRAVN-CYYGTLFLLLATLGFRMLRATSLTLFQDRKS-- 2471

  Fly   808 TQGRSHLGSYIYRKLSGMLYWITHCGRKRRHHPQASETEDKDAEHDVGAAHDETHEIRKNMTPAE 872
                .|..|.:..|...:..|.......|.....:.|||                      ...:
  Rat  2472 ----FHRKSLVTLKDVAVSMWHRLLTFLRLETTTSGETE----------------------VTTD 2510

  Fly   873 QQYFKDIPQGENQDMVRLNNRVGLLEEILEKLINNMDDI-LKRVEKDY 919
            ..|:             |:....||:|:|.|:....|.: |..:||.:
  Rat  2511 HIYY-------------LDEFSSLLDELLMKIDGLSDSLELSILEKQW 2545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	88/428 (21%)
Pkd1l1	XP_038948500.1	PCC	<242..725	CDD:188093
		GPS	1398..1436	CDD:413374
		PLAT_polycystin	1504..1622	CDD:238850
		PKD_channel	2063..2389	CDD:400395	84/460 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345341
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840