Protein Alignment Pkd2 and pkd2l1

DIOPT Version :10

• Sequence 1: NP_609561.2
• Gene: Pkd2 / 34651
• FlyBaseID: FBgn0041195
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: XP_002936910.2
• Gene: pkd2l1 / 100495064
• XenbaseID: XB-GENE-954499
• Length: 832
• Species: Xenopus tropicalis
• Alignment Length: 842
• Identity: 241/842 - (28%)
• Similarity: 374/842 - (44%)
• Gaps: 193/842 - (22%)

  Fly   104 GQSTSDKPSTSDKPSTSDKPSTSARTTVREPGPSSSPSRPVSTRESGRITFQEAAPSTSAKVVKL 168
            |:...|.|:....||...|...:.:|.:..|..:..
 Frog    24 GKRAWDNPAFDGSPSLKIKAIYNPKTVLENPYDNLE----------------------------- 59

  Fly   169 AASEPRPAKPPEKEGFSLFKRKKKSVGSSTPPSPSRGHRAPSIIAASALQNRAKTNRILYTTDEE 233
            ...:|    ||.:|.    |:.|::..|.......:|.|.   :..:.|......||.||
 Frog    60 QLGDP----PPYQEE----KKHKRNPCSQCCMYIVKGIRG---LWGTTLTENTAENRELY----- 108

  Fly   234 VREALVEFSVFIIFLILTSLVVLSVRHTYMFYFNDTMKKLFTNREMVVAPSVTVGFEKLITVPDW 298
            ::..|.|..|:|:||:...|:...:..|..:|:.:.|.|||.:.:    ....|.|:.:..:.|:
 Frog   109 IKTTLRELLVYIVFLVDICLLTYGMTSTNTYYYTNVMSKLFLDTQ----SDSGVTFKAISNMDDF 169

  Fly   299 WDYLKYNFLVTLHGDLTFMDDAQANLTSMPPEGSEQGSEQGSEQGSEQSPEEVVGEAPEEAPEMD 363
            |.||                                                       :.|.:|
 Frog   170 WSYL-------------------------------------------------------QGPMLD 179

  Fly   364 RLQEDFKYNGNPYIDLRGHRRAKRQSGVDGNSEDGSEDVSGNYLKDDSDSIQANMSFHHLEGRVF 428
            .|.....||                            :||   |.|:::|:             .
 Frog   180 GLYWTKWYN----------------------------NVS---LTDNTNSL-------------I 200

  Fly   429 LYENLLLGPPRLRQIRVRKESCYVNDAFIRYFNTCYAAYSSGAEDRKP--MHKGS--PFRTMHDL 489
            .|||||||.||:||::|:..||.|...|......|:..||...||...  :..|:  .:.|..:|
 Frog   201 YYENLLLGVPRMRQLKVKNNSCMVYKDFKDEIVGCFDVYSKDKEDTSQFGLINGTAWTYYTEEEL 265

  Fly   490 DSTPIWTVLAFYRTGGYTVNLDYDKDRNVKIINDLKDIHWLDRGSRLCLVEFNLFNENTDIFQSI 554
            ..:..|..:..|..|||.::|:..|..:::.:..||...|||||:|...|:|:::|.|.::|..:
 Frog   266 GGSSYWGKITTYSGGGYYIDLELTKRDSLRQLQTLKSNLWLDRGTRAVFVDFSVYNANINLFCVL 330

  Fly   555 KLIAEIPPTGGVIPQAHLQTVKMYSFFTDRSMLMTVIYIFWYIMVIYYTIYEITEIRKSGIKIYF 619
            :|:.|.|.|||.||...::|||:..:.:.....:....|.:.|.:.||.:.||.|:|....: ||
 Frog   331 RLVVEFPATGGAIPSWQIRTVKLIRYVSGWDYFIIGCEIVFCIFIFYYVVEEILELRIHKFR-YF 394

  Fly   620 CSMLNILDCAILLGCYLALVYNIWHSFKVMSLTARAHSDVT-YQSLDVLCFWNIIYVDMMAILAF 683
            .|:.||||..::|...:|:.::|:.:.:|..|......:.| |...:.|.||...|.:|.|:..|
 Frog   395 TSIWNILDVIVILLSLVAIGFHIFRTMEVNRLMGTLLKNPTIYADFEFLAFWQTQYNNMNAVNLF 459

  Fly   684 LVWIKIFKFISFNKTLVQFTTTLKRCSKDLAGFSLMFGIVFLAYAQLGLLLFGTKHPDFRNFITS 748
            ..||||||:||||||:.|.::||.||:||:.||::||.|||.||||||.|||||:..:|..|:..
 Frog   460 FAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAIMFFIVFFAYAQLGYLLFGTQVENFSTFVKC 524

  Fly   749 ILTMIRMILGDFQYNLIEQANRVLGPIYFLTYILLVFFILLNMFLAIIMETYNTVKGEITQGRSH 813
            |.|..|:|||||.|:.|:.||||||||||:||:..|||:|||||||||.:||:.||.|::..::.
 Frog   525 IFTQFRIILGDFDYDAIDNANRVLGPIYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELSNQKNE 589

  Fly   814 LGSYIYRKLSGML---YWITHCGRK-------------RRHHPQASETEDKDAEHDVGAAHDETH 862
            |      :.|.:|   |..|....|             :..:.:....|.|::..::|  ||: |
 Frog   590 L------QFSDILKQGYKKTLLKLKLKKERISDVQKALQNGNKELKFEEFKNSLREMG--HDD-H 645

  Fly   863 EIRKNMTPAEQQYFKDIPQGENQDMVRL--NNRVGLLEEI-----------LEKLINNMDDI 911
            ||....:..:|...:.:.:.|...|.::  ..||.|..||           ||:.: |:|||
 Frog   646 EISAAFSNFDQDGNRILDEEEQMRMKQILEERRVALNAEIENLGRSYRNKRLEEEV-NLDDI 706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	DUF5585	<29..272	CDD:465521	32/167 (19%)
		Polycystin_dom	404..578	CDD:466668	58/177 (33%)
		PKD_channel	579..803	CDD:462341	104/224 (46%)
pkd2l1	XP_002936910.2	Polycystin_dom	160..354	CDD:466668	70/292 (24%)
		PKD_channel	355..579	CDD:462341	104/224 (46%)
		SCP-1	<573..809	CDD:114219	33/144 (23%)