DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6712 and BRIX1

DIOPT Version :9

Sequence 1:	NP_477479.1	Gene:	CG6712 / 34631	FlyBaseID:	FBgn0032408	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_060791.3	Gene:	BRIX1 / 55299	HGNCID:	24170	Length:	353	Species:	Homo sapiens

Alignment Length:	294	Identity:	55/294 - (18%)
Similarity:	110/294 - (37%)	Gaps:	79/294 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 MKKEKHKKK----MQERRARRK---AGVPANPGHTIESLREKDQTEVAN---LNDSDNEELQKEL 170
            |...|.|::    :|.::.:|.   |..||....|.|.:.|:::..:..   .....|:|
Human     1 MAATKRKRRGGFAVQAKKPKRNEIDAEPPAKRHATAEEVEEEERDRIPGPVCKGKWKNKE----- 60

  Fly   171 QLDDFSSYFERSYEPKVLITFADNPVT-KTRKFGLELSRIFPN--ALVKIRNKSSVKKICKSAER 232
                           ::|| |:...:. :||....:|..:.|:  |..|:..|..:..|.:..|.
Human    61 ---------------RILI-FSSRGINFRTRHLMQDLRMLMPHSKADTKMDRKDKLFVINEVCEM 109

  Fly   233 EEFTDVVIVNEDRRKPNGLLVIHLPNGPTAHFKLSNVKLTSDIKRDHKEITKHRP---------- 287
            :.....:.....:::...:.:.:.|:||:|.|.:.|:...:::|.....:...||
Human   110 KNCNKCIYFEAKKKQDLYMWLSNSPHGPSAKFLVQNIHTLAELKMTGNCLKGSRPLLSFDPAFDE 174

  Fly   288 --------EVILNNFTTRLGLTVGRMLGALFHHDPEFRGR------RAVTFHNQRDYIFFRHHRY 338
                    |:::..|:|                 |.:..:      ...||....:.|:||:  :
Human   175 LPHYALLKELLIQIFST-----------------PRYHPKSQPFVDHVFTFTILDNRIWFRN--F 220

  Fly   339 EFTKEGKRVKLRELGPRFTLKLRSLQEGTFDSKT 372
            :..:|.  ..|.|:||||.|.|..:.:|:|...|
Human   221 QIIEED--AALVEIGPRFVLNLIKIFQGSFGGPT 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6712	NP_477479.1	Brix	188..358	CDD:214879	37/196 (19%)
BRIX1	NP_060791.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		11/44 (25%)
		Brix	58..307	CDD:294606	44/237 (19%)
		Prp31_C	321..>346	CDD:286825
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910