DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr81 and WDR83

DIOPT Version :9

Sequence 1:	NP_609535.1	Gene:	Wdr81 / 34616	FlyBaseID:	FBgn0032395	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	NP_001093207.1	Gene:	WDR83 / 84292	HGNCID:	32672	Length:	315	Species:	Homo sapiens

Alignment Length:	297	Identity:	69/297 - (23%)
Similarity:	122/297 - (41%)	Gaps:	49/297 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1621 HLKGNWLAYWRNETTRNEKDTQTLN-LKQIRLQSFVGHTNSV-RAIYALDNENSFISASKDKTVK 1683
            ::.||:..     |..::|..:..| |:...|:::.||...| .|..:.|| :|..|...||.|.
Human    34 NVDGNYCL-----TCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDN-SSLCSGGGDKAVV 92

  Fly  1684 LWSLRSEGDGRKTSACQFTYTAHKKSINSLGFLESLRYVV--SCDSGIHLWDPFIGR--PLSVLD 1744
            ||.:.|....||       :..|...:|::.|.|....::  |.||.|..||....|  |:..||
Human    93 LWDVASGQVVRK-------FRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLD 150

  Fly  1745 APRHSAVTVVKCLPSHSPLVIAGTAESTVKMVDARSCEYVNEWRVCNASLPNATVRCLAVAPSGN 1809
            ..| ..|:.|| :..|.  ::||:.:..|:..|.|..:..:::       ..:.:.|...:..|.
Human   151 EAR-DGVSSVK-VSDHE--ILAGSVDGRVRRYDLRMGQLFSDY-------VGSPITCTCFSRDGQ 204

  Fly  1810 WLAAGLSSGCIVQLDTRTGMVINSWR-------PMECDLLQLAAPSDQFLVSSALDHSLAVWHAL 1867
            ..........:..||..||.::..::       .::|.|    :..|..:||.:.|..:..|..:
Human   205 CTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCL----SERDTHVVSCSEDGKVFFWDLV 265

  Fly  1868 DGIMHYQLKPPPEPAHFLQSVG-----PSLVYATTGN 1899
            :|.:...|   |..:..:||:.     |.|:.|..|:
Human   266 EGALALAL---PVGSGVVQSLAYHPTEPCLLTAMGGS 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117
		WD40	<1644..1877	CDD:225201	58/245 (24%)
		WD40	1651..1876	CDD:295369	55/236 (23%)
		WD40 repeat	1662..1705	CDD:293791	13/42 (31%)
		WD40 repeat	1710..1744	CDD:293791	11/37 (30%)
		WD40 repeat	1752..1788	CDD:293791	8/35 (23%)
		WD40 repeat	1799..1836	CDD:293791	6/43 (14%)
WDR83	NP_001093207.1	WD40	18..295	CDD:238121	67/291 (23%)
		WD 1	23..62		7/32 (22%)
		WD40 repeat	30..65	CDD:293791	7/35 (20%)
		WD 2	65..104		14/39 (36%)
		WD40 repeat	71..107	CDD:293791	13/43 (30%)
		WD 3	107..146		11/38 (29%)
		WD40 repeat	112..150	CDD:293791	11/37 (30%)
		WD 4	151..188		10/40 (25%)
		WD40 repeat	157..187	CDD:293791	8/32 (25%)
		WD 5	190..228		6/37 (16%)
		WD40 repeat	194..230	CDD:293791	6/35 (17%)
		WD 6	231..272		8/44 (18%)
		WD40 repeat	238..272	CDD:293791	8/37 (22%)
		WD 7	275..313		6/25 (24%)
		WD40 repeat	279..303	CDD:293791	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910