DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr81 and AT3G60920

DIOPT Version :9

Sequence 1:	NP_609535.1	Gene:	Wdr81 / 34616	FlyBaseID:	FBgn0032395	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	NP_001325702.1	Gene:	AT3G60920 / 825263	AraportID:	AT3G60920	Length:	1992	Species:	Arabidopsis thaliana

Alignment Length:	1961	Identity:	369/1961 - (18%)
Similarity:	606/1961 - (30%)	Gaps:	747/1961 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 VIYQILQLAKHLQGQGLFLGDLRLQDIVLRENLWLQV----LPRLQCNLLDD------------D 294
            |.:..:|   ||.|..|.:.||         ..||.|    ||.:..|.|.|            .
plant     7 VFFHCIQ---HLAGHSLSVDDL---------YRWLHVIKKSLPTVWSNPLIDALEKAMNGKESRG 59

  Fly   295 PA------GEDMSPLTPLVSE-------------------DLGEAREAQQALPSSSTMFDLRFAY 334
            ||      ||....|.|..|.                   |..:|..|..|:.::|..
plant    60 PACSFEFVGESSGLLGPGESRWPFTNGYAFATWIYIESFADTLDASTAAAAIAAASAA------- 117

  Fly   335 DPAHFNLREYTEMWCNGQLSN------------------FDYLTILNNACGRSLTNAAYHHIMPW 381
                          .:|::||                  |.:||..|...      .||.:....
plant   118 --------------KSGKISNAAPANVHTGEGTAHMPRLFSFLTPDNQGI------EAYFYAQFL 162

  Fly   382 VTDFSGRGGGAWRDL------------------TKSKYRLNKGDVHLDLMYAHASQHG------- 421
            |.: ||.|.|:...|                  |.::..|...|..|.| |...|.:.
plant   163 VVE-SGSGKGSKTSLHFTHAFKPQCWYFIGLEHTCNQGLLGNSDSELRL-YIDGSLYETRPFDYP 225

  Fly   422 --SADGSYQAIGDQAPHHVSDFLSEITYFVYMARRTPQSILCAHVRPIWVPAEYPVSIQRLQEWT 484
              |...|:..||...|...:.          :.||..|..|.|.:.|:::..| |:..:|:....
plant   226 RISKPLSFCCIGSNPPSTTAG----------LQRRRRQCALFAEMGPVYIFKE-PIGPERMTRLA 279

  Fly   485 P--DECIPEFYSD---PMIFKSIH-------EDLPDLELPAWATCPEDFICKHREALESQYVSER 537
            .  .:.:|.|.:.   |.:..:.|       ..|.|.||..:.     .:..|...|..::..:.
plant   280 TRGGDVLPCFGNGAGLPWLATNDHVRNVAEESSLSDAELGGYI-----HLLYHPCLLSGRFCPDA 339

  Fly   538 LHHWIDLNFGYKLSGKAAVKSKNVCLTLVDQHRNLSQRGIVQLFASAHPPRRYATPWFSRTAPRL 602
                       .|||.|.           |:....|...:|  ||..:    ...|:|.|....|
plant   340 -----------SLSGAAG-----------DEKTPYSFSAVV--FALCY----LVFPYFGRPMSLL 376

  Fly   603 SQLYASPAKRLAKSTENLQAESATGSSHLSLRLGDDGSSGSVHSSSASASASNFYAIT---NFIE 664
            ....:|..|      :||:..|....|.|           :.:|.:|.......:||.   |..|
plant   377 PLTVSSVHK------DNLEPCSRNVPSSL-----------TTYSLAAPIFRMISFAIKHPGNNEE 424

  Fly   665 LPENYNPAL-------LLHNLETLEAFYARTFPQQRASANPEEKMISSDLMFEQNSAEHSFTNQL 722
            |.....|.:       |||:|.:.:..:.|...::..:|     ::|   :.:.....|:...||
plant   425 LSRTRGPEILATVLGYLLHSLASFDIKHDRVGDEELVAA-----IVS---LCQSQKINHALKVQL 481

  Fly   723 FAS-----------GDELPPKSKNLLRE--------KRN----------CLQHLLNVRKE----- 753
            |.:           ...|..|..:.|::        .||          |.::...::::
plant   482 FCTLLLDLKIWSVCSYRLQKKLLSSLQDMVFTEATAMRNADAIQVLLDGCRRYFWTIQEKDSVNT 546

  Fly   754 -------RDLHVLGCLIIELFAMQRLRPLLMGNGLTATFDSRLSACRTVAQLHRQ-----ELPKP 806
                   |.:..:..|:.||..   :..||||         ..|.......|||.     |.|:|
plant   547 FSLDGDARQVGEVNALVDELLV---IIELLMG---------AASPSFAADDLHRLLGFIIESPQP 599

  Fly   807 --VRRVVRLLLQLEQPGEEDQGLPQP-PNPAQLLEPMF------SNLLLPFPSHYMAVYALVRSL 862
              |.||:.|:.:|         :.|| ...||.....|      ..||:               |
plant   600 NQVARVLHLMFRL---------VVQPNAAKAQTFAEAFITSGGIETLLV---------------L 640

  Fly   863 HAFEANAVLLE------LQTHFS----CKGGR-------ECERYTEM--------------DRQR 896
            .|...|.:.||      ::.|.|    |:.|.       ..:|.:.:              ||.|
plant   641 IANRVNTMGLETESFQQVKVHGSETVICETGSVTLSSSVNADRISSVSETPFNNNARNNVDDRDR 705

  Fly   897 VLFERKIAECKVMSCC---AHVKRLLEPMS------------------FAYEQFTPVELLLPHII 940
            |:    :...:::...   .|:|..:...|                  |.|:    |.|||..::
plant   706 VM----VGIIRLIGALISKGHLKFSVGAKSDVMSNLMGSEFRENGGTMFDYK----VALLLFALL 762

  Fly   941 DLLRDERTSILTAWNLFDPIAQA-LGVSQTQQHL---------LQPLLKLYDVESVSSPDDGGSN 995
            ...:.....::|. |::..:..| :..|.|:..|         ..|.|.|..:.|:........|
plant   763 KAFQAAPNRLMTD-NVYTTLLGASVNASSTEDGLNFCDLGHRFEHPQLLLILLRSLPFASKALQN 826

  Fly   996 GSTNSGGHLRFSASSSFKSRKSVKLYHH--SFLLRLIVR-----FGLRC----------FLHHFI 1043
            .:...   :.|.|.:..:.|.|:.....  .::|.:::.     .|.:.          .:|:|:
plant   827 RALQD---ILFLACTHPEKRSSLTKMEEWPEWILEILISNYEKDAGKQSASPGSAEEEDLIHNFL 888

  Fly  1044 APLIE----AVGGYKEPEQGNGYHYHS-------GGSRRTSKNLNFASENEVHQTEVAPEMKPD- 1096
            ..::|    ...|:|:.|.    ..|.       |||.        ..|..:.:.|..|..|..
plant   889 IIMLEHSMRQKDGWKDIEA----TIHCAEWLTFVGGSS--------TGEKRIRREESLPIFKRRL 941

  Fly  1097 IEELFTFEDDHDRASTQDSKSIDSFDMRPSTSAASAEEARESDGSPDK-------------LVIN 1148
            :..|..|.....:|.||            ..:||||..|.||....|.             ||.|
plant   942 LGGLLDFAASELQAQTQ------------VIAAASAGFAAESLTPKDAKAGVENAALLSVFLVEN 994

  Fly  1149 ELIYGARISPDKLSLKESQ-----------TPPALVPPPIGPRSPTIEIPMGPTAGGIRRSFQLS 1202
            .::. ..:..|.|.|:..|           :|.:||.|| ..||.|:     ||.|   .|.::|
plant   995 TVVI-LMLVEDHLRLQSKQNCAASAVDVSPSPLSLVYPP-NYRSHTL-----PTVG---ESSEVS 1049

  Fly  1203 AIDCDIGSRKSVDSFDLISQAVEQLPPPAEESEAEASDSLQASVISRLSEAKAVQ---------- 1257
            :....:.|.......|:::            |.|:||..:..:|:.||:.|.|.:
plant  1050 SSCASVSSDSGGVHLDILA------------SMADASGQISTAVMERLAAAAAAEPYESVSCAFV 1102

  Fly  1258 ------NNRISEMSAESLVWLSHRLGPVLTSRFITRNLLKLLSLCYVGQENLLPEVDDGGSSFNS 1316
                  .:........|.:|....| |..||             |:.|          |||.::|
plant  1103 SYGSCTRDLADAWKYRSRLWYGVGL-PSKTS-------------CFGG----------GGSGWDS 1143

  Fly  1317 -----SPDAAN-------------------LNYFSIANARVVGDRSAA---------RVLE---- 1344
                 ..||..                   |:...:.....:|..|..         ::|:
plant  1144 WKHALQKDAQGNWIELPLVKKSVSMLQALLLDESGLGGGLGIGGGSGTGMGGMSGLYQLLDSDQP 1208

  Fly  1345 --CLMSIAAL------YGENFLLLQYFPHISELISLCSK-RITGSLEGAIISSLQLLKYMVPCLT 1400
              |::.:..|      :||:.||::         :|.|: .|||.|:             .|...
plant  1209 FLCMLRMVLLSLREEDHGEDSLLMK---------NLSSEDGITGGLQ-------------CPLGN 1251

  Fly  1401 DASI-------MEHLQHIMLDAILLPIL----------RLLSSTNLVMPSGYLGRSL----LARK 1444
            .||:       |......:|.::|.|:|          |:|.:|.::....:...|.    |.::
plant  1252 SASVDISSQLSMRQSPSALLWSVLSPVLNMPISDSKRQRVLVTTCVLYSEVWNAVSKDKRPLRKQ 1316

  Fly  1445 FLDAIYALSVRLGSDMTREHLCQPLL------------NPFFLIFNKAF---GLPNDFACDLANL 1494
            :|:||....|.:   :.|   .:|||            || .::..:|.   .||.:.|..:.:.
plant  1317 YLEAILPPFVAI---LRR---WRPLLAGIHELSTGDGVNP-LVVDTRALAADALPIEAALSMISP 1374

  Fly  1495 SLVGGASQPERALEELRDVFG---------------PELAHTAYLTFLRFLGEANMKRTLSNLDF 1544
            ......:.|..|:.......|               |.|...:.|          ::|..:.|..
plant  1375 EWAAAFASPPSAMALAMIAAGAAGWEAPAHPAPPAPPPLRRDSSL----------LERKSTKLQT 1429

  Fly  1545 VLTLCHEHEQPN----GQSKIQLATNVSSGQDVDSVDASCELAANSFGTQIVGNRLQVARNNVEL 1605
            ..:.....|.||    |:::.:.|.|:.|...:..:            |::.|
plant  1430 FSSFQKPLEAPNDDTPGRARDKAAANIDSHLLIQPL------------TRLTG------------ 1470

  Fly  1606 IDMVAYKLDQMPKTRH----LKGNWLAYWRNETTRNEKD-TQTLNLKQIRLQSFVGHTNSVRAIY 1665
               |.:|||.|..:..    |:.|:......|||||..| |..:|          .|.:.|.|:.
plant  1471 ---VFWKLDSMESSSRMRQCLRRNYSGTGHLETTRNYGDQTYLMN----------NHDSPVLAVE 1522

  Fly  1666 ALDNENSFISASKDKTVKLWSLRSEGDGRKTSACQFTYTAHKKSINSLGFLESLRYVVSCDSGI- 1729
            |:..|   |....|:......|..||:           ...:|..|......||...::..:||
plant  1523 AISKE---IMYEDDEHGDADDLEIEGN-----------VGERKGENEERRSGSLEDAITLSTGIN 1573

  Fly  1730 -HLWDPFIGRPLSVLDAPRHSAVTVVKCLPSHS-------------PL-VIAGTAESTVK----M 1775
             |       ||||..:..::|  |.||.|....             || |:.||.:.|.:    :
plant  1574 DH-------RPLSEQNMVQNS--TEVKDLSELKERIVLEISSTMVRPLGVVKGTFQITTRRINFI 1629

  Fly  1776 VDARSCEYVNE 1786
            ||.|..::::|
plant  1630 VDIREDQHLDE 1640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117	55/299 (18%)
		WD40	<1644..1877	CDD:225201	37/163 (23%)
		WD40	1651..1876	CDD:295369	36/156 (23%)
		WD40 repeat	1662..1705	CDD:293791	8/42 (19%)
		WD40 repeat	1710..1744	CDD:293791	10/35 (29%)
		WD40 repeat	1752..1788	CDD:293791	14/53 (26%)
		WD40 repeat	1799..1836	CDD:293791
AT3G60920	NP_001325702.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920