DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr81 and WDFY4

DIOPT Version :9

Sequence 1:	NP_609535.1	Gene:	Wdr81 / 34616	FlyBaseID:	FBgn0032395	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	XP_011538288.2	Gene:	WDFY4 / 57705	HGNCID:	29323	Length:	3224	Species:	Homo sapiens

Alignment Length:	542	Identity:	125/542 - (23%)
Similarity:	191/542 - (35%)	Gaps:	139/542 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 DC--ITFSPALLGKNYNKTLF--------VIYQILQLAK------------HLQGQGLFLGDLRL 269
            ||  :||.|||....:::...        ::.::|...|            ||..:|:.|  ...
Human  2391 DCTQLTFFPALHESLHSEDFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLL--FGH 2453

  Fly   270 QDIVLRENLWLQVLPRLQC--------------NLLDDDPAGEDMSPLTPLVSEDLGEAREAQQA 320
            |...:.||..|.....:.|              ||...|.:.:..|......: |:.|.|:|:..
Human  2454 QHFYICENFTLSPTGDVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYA-DMRELRQARFL 2517

  Fly   321 LP---------------------SSSTMFDLRFAYDPA---------HFNLREY-------TEMW 348
            |.                     ..|..|....::.|:         ..:||.|       .:.|
Human  2518 LQDIALEIFFHNGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLSLRRYPGSDRIMLQKW 2582

  Fly   349 CNGQLSNFDYLTILNNACGRSLTNAAYHHIMPWVTDFSGRGGGAWRDLTKSKYRLNKGDVHLDLM 413
            ....:|||:||..||.|.||:..:...:.:.|||.          .|.|.....|....:..||.
Human  2583 QKRDISNFEYLMYLNTAAGRTCNDYMQYPVFPWVL----------ADYTSETLNLANPKIFRDLS 2637

  Fly   414 YAHASQHGSADGSY--------QAIGDQAP--HHVSDFLSEITYFVYMARRTP-QSILCA----- 462
            ....:|.......:        :..||...  |:.:.:.|.|....|:.|..| ....||
Human  2638 KPMGAQTKERKLKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGS 2702

  Fly   463 ---------HVRPIWVPAEYPVSIQRLQEWTPD-ECIPEFYS--DPMIFKSIHED--LPDLELPA 513
                     .|:..|..|... ::..::|.||: ..:|||.:  :.:.|..:.:.  |.|::||.
Human  2703 FDVADRMFHSVKSTWESASRE-NMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPP 2766

  Fly   514 WAT-CPEDFICKHREALESQYVSERLHHWIDLNFGYKLSGKAAVKSKNV-----------CLTLV 566
            ||. .|..||..||:||||.:||..|||||||.||||..|.|||.:.|:           ..::.
Human  2767 WADGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLSSIT 2831

  Fly   567 DQHRNLSQRGIV--------QLFASAHPPRRYA-TPWFSRTAPRLSQLYASPAKRLAKSTENLQA 622
            |.....:..|.|        |||...||.|..| .|...:.......|...| :....|.::|:.
Human  2832 DPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHP-QPFFYSLQSLRP 2895

  Fly   623 ESATGSSHLSLRLGDDGSSGSV 644
            ...|........||.:...|::
Human  2896 SQVTVKDMYLFSLGSESPKGAI 2917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117	81/292 (28%)
		WD40	<1644..1877	CDD:225201
		WD40	1651..1876	CDD:295369
		WD40 repeat	1662..1705	CDD:293791
		WD40 repeat	1710..1744	CDD:293791
		WD40 repeat	1752..1788	CDD:293791
		WD40 repeat	1799..1836	CDD:293791
WDFY4	XP_011538288.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920