DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr81 and Wdfy4

DIOPT Version :9

Sequence 1:	NP_609535.1	Gene:	Wdr81 / 34616	FlyBaseID:	FBgn0032395	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	XP_006252821.1	Gene:	Wdfy4 / 498582	RGDID:	1564142	Length:	3187	Species:	Rattus norvegicus

Alignment Length:	858	Identity:	185/858 - (21%)
Similarity:	280/858 - (32%)	Gaps:	322/858 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LLDRRSYPIG-QLE-----HPWTRILVQTYRKQPQSRVYPLPRISGDAPSS-------------- 97
            ||:.||||.| .||     :|:.::.:....:....:...||.: ||...|
  Rat  2062 LLNARSYPEGFGLEPKPRINPYHQVFLSPSEEVKDKKEEGLPSL-GDVQHSIQKSVRALWQQLVA 2125

  Fly    98 ----------ELPLSYSQAVSFVAHSNFKQLWEE----AYRKYNGAHVRMCRSTPSAP-STKPPS 147
                      ::.||.....|.|.......||||    |::.|..:..:...|..|.. .:|..|
  Rat  2126 QRRQTLEDAFKIDLSVKAGESEVKIEEVTPLWEETMLRAWQHYLASEKKSLASRSSVTHHSKATS 2190

  Fly   148 GQGQL-----------------QPHDVVL---------KELIQRVYRCPVLHCQLDRDGVSDSS- 185
            ..|.|                 :..|.|.         :||...:|:..|.  :..||.:..::
  Rat  2191 WSGSLSSAMRLMPGRQAKDPECRAEDFVSCIENYRRKGQELYASIYKDYVQ--RRKRDSIKAATA 2253

  Fly   186 -------------------NATSCS---------------------------AGSCHAN------ 198
                               .:||||                           .|||..:
  Rat  2254 WARMQEQLFGELGLWGRMRESTSCSQWELDRREGPARMRKRIRRLCAWETLNLGSCKESQDQRGD 2318

  Fly   199 ---------VLPAL-----VAIETS-----------THISVFFYPPALECSLYD------C---- 228
                     |.|..     :.||.:           |.::.|   |||..||:.      |
  Rat  2319 VSQTNAENQVCPVFRIADELTIEEAESRPDEVGVDCTQLTFF---PALHESLHSEDFLELCRERQ 2380

  Fly   229 ITFSPALLGKNYN-KTLFVIYQILQLAKHLQGQGLFLGDLRLQDIVLRENLWLQVLPRLQC---- 288
            |.....|.|:..: |...||.|     .||..:|:.|  ...|...:.||..|.....:.|
  Rat  2381 IILQELLDGEKVSQKVPMVIVQ-----GHLVSEGILL--FGQQHFYVCENFTLSPTGDVYCTHHC 2438

  Fly   289 ----------NLLDDDPAGEDMSPLTPLVSEDLGEAREAQQALPSSSTMFDLRFAY--------- 334
                      |:...|.:.:..|......| ||.|.|:|:..|...:.....:..|
  Rat  2439 LSNISDPFIFNMCSKDRSSDHYSCQRHAYS-DLRELRQARFLLQDIALEIFFQNGYSKLLVFYNS 2502

  Fly   335 -----------------------DPAHFNLREY-------TEMWCNGQLSNFDYLTILNNACGRS 369
                                   ||  ||||.:       .:.|...::|||:||..||...||:
  Rat  2503 DRSKAFKSFCTFQPSLKGKGTTEDP--FNLRRHPGFDRTMLQKWQKREMSNFEYLMYLNTLAGRT 2565

  Fly   370 LTNAAYHHIMPWV-TDFSGR-----GGGAWRDLTK-----SKYRLNK------------GDVHLD 411
            ..:...:.:.||| .|::..     ....:|||:|     ||.|..|            ||:.:.
  Rat  2566 YNDYMQYPVFPWVLADYTSEMLNLTNPKTFRDLSKPMGAQSKERKLKFTQRFKDIEKIEGDMTVQ 2630

  Fly   412 LMYAHASQHGSADGSYQAIGDQAPHHVSDFLSEITYFVYMARRTP-QSILCA------------- 462
            .                       |:.:.:.|.|....|:.|..| ....|:
  Rat  2631 C-----------------------HYYTHYSSAIIVASYLVRMPPFTQAFCSLQGGSFDVADRMF 2672

  Fly   463 -HVRPIWVPAEYPVSIQRLQEWTPD-ECIPEFYS--DPMIFKSIHE--DLPDLELPAWAT-CPED 520
             .|:..|..|. ..::..::|.||: ..:|||.:  :.:.|..:.:  .|.|::||.||. .|..
  Rat  2673 HSVKNTWESAS-KENMSDVRELTPEFFYLPEFLTNCNAVEFGRMQDGTTLGDVQLPPWADGDPRK 2736

  Fly   521 FICKHREALESQYVSERLHHWIDLNFGYKLSGKAAVKSKNV-----------CLTLVDQHRNLSQ 574
            ||..||:||||.:||..|||||||.||||..|.|||::.|.           ..::.|.....:.
  Rat  2737 FISLHRQALESDFVSSNLHHWIDLIFGYKQQGPAAVEAVNTFHPYFYGDRIDLSSITDPLIKSTI 2801

  Fly   575 RGIV--------QLFASAHPPR----RYATPWFSRTAP------RLSQLYASPAKRLAKSTE--- 618
            .|.|        |:|...||.|    :...|....:.|      ..|.|::.||.|.::.|.
  Rat  2802 LGFVSNFGQVPKQIFTKPHPSRNTTGKSPVPGKETSTPTGLPGHSQSFLHSLPALRPSQVTVKDM 2866

  Fly   619 ---NLQAESATGS 628
               :|.:||..|:
  Rat  2867 YLFSLGSESPKGA 2879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117	81/305 (27%)
		WD40	<1644..1877	CDD:225201
		WD40	1651..1876	CDD:295369
		WD40 repeat	1662..1705	CDD:293791
		WD40 repeat	1710..1744	CDD:293791
		WD40 repeat	1752..1788	CDD:293791
		WD40 repeat	1799..1836	CDD:293791
Wdfy4	XP_006252821.1	PH_BEACH	2390..2514	CDD:275391	24/131 (18%)
		Beach	2542..2823	CDD:280327	81/304 (27%)
		WD40	<2865..3187	CDD:225201	4/15 (27%)
		WD40	<2905..3103	CDD:295369
		WD40 repeat	2940..2983	CDD:293791
		WD40 repeat	2989..3025	CDD:293791
		WD40 repeat	3030..3064	CDD:293791
		WD40 repeat	3074..3120	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1786
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910