DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr81 and AgaP_AGAP012488

DIOPT Version :9

Sequence 1:	NP_609535.1	Gene:	Wdr81 / 34616	FlyBaseID:	FBgn0032395	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	XP_001230447.2	Gene:	AgaP_AGAP012488 / 4397653	VectorBaseID:	AGAP012488	Length:	496	Species:	Anopheles gambiae

Alignment Length:	446	Identity:	87/446 - (19%)
Similarity:	159/446 - (35%)	Gaps:	132/446 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1301 ENLLPEVD-DGGSSFNSSPDAANLNYFSIANARVVGDRSAARVLECLMSIAALYGENFLLLQY-- 1362
            :|..||:: ..|:..||.|                   :.|:|::.|.   ||..::.||:.|
Mosquito    23 KNTTPEIEPQSGTMCNSEP-------------------TTAQVMDILQ---ALIIDSLLLMPYTK 65

  Fly  1363 FPHISELISLCSKRITGSLEGAIISSLQ----LLKYMVPCLTDASIMEHLQHIMLDAILLPILRL 1423
            .|.:.:|:      :...:.|:|||..:    |.:.::..:.:||:.:     :.|....|.|
Mosquito    66 TPPVIDLV------LDFYISGSIISLNERKTFLTEIILLLMKNASLND-----ITDGQKTPFL-- 117

  Fly  1424 LSSTNLVMPSG--YLGRSL--LARKFLDAIYALSVRLGSDMTREHLCQPLLNPFFLIFNKAFGLP 1484
              :.|.:..:|  ||..::  :..:|:|.::...:.:......:: |..|||.   :...|...|
Mosquito   118 --NNNDIKFTGQEYLLTNIFYMTARFVDKLWQQMLLIDGREVFDY-CVTLLNH---VKRTASRTP 176

  Fly  1485 NDFACDLANLSLVGGASQPERALEELRDVFGPELAHTAY------LTFLRFLGEANMKRTL---- 1539
            :     |||    .|.:...|:|...      .|...||      :|.:..|.:....|.|
Mosquito   177 S-----LAN----NGGNSLYRSLNRC------ILYLLAYPPAPFNITLVEILNKLMYNRLLVFGA 226

  Fly  1540 --SNLDFV--LTLC----HEHEQPNGQSKIQLATNVSSGQDVDSVDASCELAANSFGTQIVGNRL 1596
              .:.||:  ||.|    |:.::|        ..::.|     ..|........||.   |...|
Mosquito   227 GNHDPDFIGCLTYCIIQLHKGDKP--------ILHIPS-----QFDQQRTTTRMSFR---VWEEL 275

  Fly  1597 QVARNNV--ELIDMVAYKLDQMPKTRHLKG-----------NWLAY---WRNETTRNEKDTQ--- 1642
            .|.:..|  |:..:......|..:..::||           :||||   .:|...||..|..
Mosquito   276 YVCKKPVIEEVFKVTLASPFQNCRAPNIKGTYDQIFESAFKHWLAYVEGEKNAVIRNPWDVHNNI 340

  Fly  1643 -----------TLNLKQIRLQSFVGHTNSVR-AIYALDNENSFISASKDKTVKLWS 1686
                       |....:.:|:..:...|.|| ..|..::....::|......:.|:
Mosquito   341 QSKIQKVTGGLTRLTSRTKLKKDISERNDVRFDQYNTESNKQLVNAKITLIEEFWN 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117
		WD40	<1644..1877	CDD:225201	7/44 (16%)
		WD40	1651..1876	CDD:295369	7/37 (19%)
		WD40 repeat	1662..1705	CDD:293791	4/26 (15%)
		WD40 repeat	1710..1744	CDD:293791
		WD40 repeat	1752..1788	CDD:293791
		WD40 repeat	1799..1836	CDD:293791
AgaP_AGAP012488	XP_001230447.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1786
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900