DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr81 and Lis-1

DIOPT Version :9

Sequence 1:	NP_609535.1	Gene:	Wdr81 / 34616	FlyBaseID:	FBgn0032395	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	NP_001246361.1	Gene:	Lis-1 / 36791	FlyBaseID:	FBgn0015754	Length:	411	Species:	Drosophila melanogaster

Alignment Length:	403	Identity:	85/403 - (21%)
Similarity:	149/403 - (36%)	Gaps:	110/403 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1535 MKRTLSNLDFVLTLCHEHEQPNGQSKIQLATNVSSGQDVDSV-------DASCELAANSFG---- 1588
            ||..||.        .:.|:.|.    .:|..:.|....||:       |.|.|: ...||
  Fly     1 MKMVLSQ--------RQREELNQ----AIADYLGSNGYADSLETFRKEADLSTEV-EKKFGGLLE 52

  Fly  1589 ---TQIVGNRLQVARNNVELIDMVAYKLDQMP-KTRHLKGNW---------LAYWRNETTR---- 1636
               |.::..:.:|.....:|.:.....::..| |.:...|.|         |...|...||
  Fly    53 KKWTSVIRLQKKVMELEAKLTEAEKEVIEGAPTKNKRTPGEWIPRPPEKFSLTGHRASITRVIFH 117

  Fly  1637 -------NEKDTQTLNLKQIRL----QSFVGHTNSVRAIYALDNENSFI-SASKDKTVKLWSLRS 1689
                   :..:..|:.:.....    :|..|||:||:.: |.|.:...: |.|.|.::|||
  Fly   118 PIFALMVSASEDATIRIWDFETGEYERSLKGHTDSVQDV-AFDAQGKLLASCSADLSIKLW---- 177

  Fly  1690 EGDGRKTSACQFTYTAHKKSINSLGFLESLRYVVSC--DSGIHLWDPFIGRPLSVLDAPRHSAVT 1752
              |.:::..|..|...|..:::|:.|:.:..||:|.  |..|.:|:...|..:......|.
  Fly   178 --DFQQSYECIKTMHGHDHNVSSVAFVPAGDYVLSASRDRTIKMWEVATGYCVKTYTGHRE---- 236

  Fly  1753 VVKCLPSHSPLVIAGTA--ESTVKMVDARSCEYVNEWRVCNASLPN--ATVRCLAVAP------- 1806
            .|:.:..|....|..|.  :.|:::       ::...:.|...|.:  .||.|:|.||
  Fly   237 WVRMVRVHIEGSIFATCSNDQTIRV-------WLTNSKDCKVELRDHEHTVECIAWAPEAAASAI 294

  Fly  1807 -------------SGNWLAAGLSSGCIVQLDTRTGMVI------NSWRPMECDLLQLA-APSDQF 1851
                         .|.:||:|.....|...|...|:.:      ::|      :..|| .|..::
  Fly   295 NEAAGADNKKGHHQGPFLASGSRDKTIRIWDVSVGLCLLTLSGHDNW------VRGLAFHPGGKY 353

  Fly  1852 LVSSALDHSLAVW 1864
            |||::.|.::.||
  Fly   354 LVSASDDKTIRVW 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117
		WD40	<1644..1877	CDD:225201	58/259 (22%)
		WD40	1651..1876	CDD:295369	58/252 (23%)
		WD40 repeat	1662..1705	CDD:293791	11/43 (26%)
		WD40 repeat	1710..1744	CDD:293791	9/35 (26%)
		WD40 repeat	1752..1788	CDD:293791	5/37 (14%)
		WD40 repeat	1799..1836	CDD:293791	13/62 (21%)
Lis-1	NP_001246361.1	LisH	9..40	CDD:128913	7/34 (21%)
		WD40	100..409	CDD:238121	63/291 (22%)
		WD40 repeat	111..148	CDD:293791	4/36 (11%)
		WD40 repeat	154..191	CDD:293791	11/43 (26%)
		WD40 repeat	196..232	CDD:293791	9/35 (26%)
		WD40 repeat	239..274	CDD:293791	5/41 (12%)
		WD40 repeat	280..336	CDD:293791	12/55 (22%)
		WD40 repeat	342..378	CDD:293791	9/25 (36%)
		WD40 repeat	384..408	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442361
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930