DRSC/TRiP Functional Genomics Resources

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Protein Alignment Wdr81 and Wdr62

DIOPT Version :9

Sequence 1:NP_609535.1 Gene:Wdr81 / 34616 FlyBaseID:FBgn0032395 Length:1953 Species:Drosophila melanogaster
Sequence 2:NP_001259886.1 Gene:Wdr62 / 33367 FlyBaseID:FBgn0031374 Length:2397 Species:Drosophila melanogaster


Alignment Length:1684 Identity:313/1684 - (18%)
Similarity:509/1684 - (30%) Gaps:576/1684 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 DPQHVCEAGGDGRFQVICDKAWLQSLERNRRLTHFPSWPLLDRRSYPIGQLEHPWTRILVQTYRK 78
            |.:|:..|.|||     |...|                           |:.|.   ::|....:
  Fly   731 DCRHLISASGDG-----CIFIW---------------------------QVPHD---MIVTMQAR 760

  Fly    79 QPQSRV----YPLPR----------ISGDAPSSELPLSYSQAVSFVAH--SNFKQLWEEAYRKY- 126
            ..|.|:    .||||          |..::|:||:.....|....||.  |:..||.:.|.||. 
  Fly   761 MSQQRLRSGHAPLPRPLAPISPPDGIVLESPTSEIEQPQLQPKFGVAERFSDVGQLPQWAMRKAA 825

  Fly   127 ----NGAHVRMCRSTPSAPSTKPP-----SGQGQL------QPHDVVLKELIQRVYRCPVLHCQL 176
                :||   :...|||..|...|     |..|.|      |...:..:...:...|...|....
  Fly   826 ADSDSGA---LSIPTPSGGSATVPGMHAASSMGNLSSSPSQQMTGLAPRARGRWAQRSTQLETAD 887

  Fly   177 DRDGVSDSSNATSCSAGSCHANVLPALVAIETSTHISVFFYPPALECSLYDCITFSPALL----- 236
            |....|:|...|..|.|. |:.     |.::||.:.|         .|..| ||::...|     
  Fly   888 DLRSNSESPLGTVSSVGG-HSG-----VNVQTSDYNS---------ASSKD-ITYNQTYLSEDSS 936

  Fly   237 ---------------GKNYNKTLFVIYQILQLAKHLQ------GQGLFLGDLRLQDIVLRENLWL 280
                           |.:.|.|:..:..:..:|....      |.|.....|:|.|..|:..|  
  Fly   937 IDSGMETRRGELKFIGSSNNGTVVTVSSVSSIAVSASNGAMSTGSGAAQQRLQLPDKRLKPGL-- 999

  Fly   281 QVLPRLQCNLLDDDPAGEDMS-----------------PLTP------LVSEDLGEAREA----- 317
                |...:..|.|...||:|                 |.||      .::||  |.|::     
  Fly  1000 ----RFDTHTHDHDGDVEDISDGERTSSDHGMFYNNLAPSTPTDFKVTAMNED--ELRKSVRRQK 1058

  Fly   318 -----QQALPS----------SSTMFDLRFAYD----PAHFNLREYTEMWCNGQLSNFDYLTILN 363
                 .|..||          :||........|    |:..|..........|...|..      
  Fly  1059 FEKSGLQLTPSALSGNGSSHTASTGTGTSDTEDEGSTPSAENAERSLASTLGGSSENLP------ 1117

  Fly   364 NACGRSLTNAAYHHIM---PWVTDFSGRGGGAWRD------------------LTKS-------- 399
                :|.||:..|..:   |.:|....|||.:.|.                  :|||        
  Fly  1118 ----QSSTNSFLHAALPEGPGLTTPMERGGSSRRSISAKHNTENGKSVAAPPTITKSYTSTKKEE 1178

  Fly   400 --------KYRLNKG-------------DV-HLDLMYAHA----SQHGSADGSYQAIGD----QA 434
                    |.:|..|             :| |..|..:|:    |...:.|||..|.|.    |.
  Fly  1179 LLQVINKVKQQLENGTRKNGNTRLNAIAEVGHRPLRGSHSISDLSLAANLDGSRNAGGGPGRYQK 1243

  Fly   435 P---HHVSDFLS-EITYFVYMARRTPQSILCAHVRPIWVPAE-YPVSIQRLQEWTPDECIPEFYS 494
            |   |..|.:.| :.|........|.|.|.....:...:|.| :..:.|:.|::.| ....:|::
  Fly  1244 PVDSHDTSQYTSPQNTTATAAPTNTQQQIQPPVQQQYQIPKEPHQQAQQQHQQYAP-PASQQFFN 1307

  Fly   495 DPMIFKSIHEDLPDLELPAWATCPEDFICKHREALESQYVSERLHHWIDLNFGYKLSGK-AAVKS 558
            .......:.::...:..          :.:|...........::|....:.||...:|. :|::|
  Fly  1308 CAAPKSKLQQNFQTMRQ----------VQQHYPPYPHHVGVHQIHPPPGVPFGGSAAGSTSAMRS 1362

  Fly   559 KNVCLTLVDQHRNLSQR-------------GIVQLFAS-----AHPPRRYATPWFSRTA----PR 601
            .:.......|.:...||             .|::.:.|     .|....::.....|.|    |:
  Fly  1363 HSQPQNRQQQQQQQQQRAKRNPAGNNRRTPSILKHYKSCPVSPVHEEVEWSAEGNERGALLGEPK 1427

  Fly   602 LSQLYASPAK---------------RLAKSTENLQAESATGSSHLSLRLGDDGSSGSVHSSSASA 651
            ...:||..|:               .:.:...:|.......|..:...|.:.|..||...|:.:.
  Fly  1428 RHSVYADDARTILDMIHADTEKMIDEITRKYGDLDEPGIPASYSMPANLRNLGGLGSTGDSTPTG 1492

  Fly   652 SASNFYAITNF------IELPENYNPALLLHNLETLEAFYARTFPQQRASANPEEKMISSDLMFE 710
            ..:.:|....|      :.|.:...|.....:...|:.  ||....||.|:       :|..:..
  Fly  1493 RTTQYYVYREFYQCERKVSLSDILQPEQFAASQRRLDE--ARFLETQRHSS-------ASFFLTG 1548

  Fly   711 QNSAEHSFTNQLFASGDELPPKS-----KNLLREKRNCL-------QHLLNVRKERDLHVLGCLI 763
            |.|.|   :..|.:.||  .|.|     :::|.::.:|.       |..:.|.::|...:...:|
  Fly  1549 QQSQE---SLSLLSDGD--GPGSYCNSLESVLSDESDCQSAPLEYPQTQVAVLQQRHAGIRNFII 1608

  Fly   764 ----------------------------------IELFAMQRLRPL------------------- 775
                                              :..:.::.|:||                   
  Fly  1609 HGPVSKSYGNSPNAYGSFDYYMRQQHSTTTDSFDVTGYNLEPLKPLPSSKTYPRIAQVQASENIP 1673

  Fly   776 -LMGNGLTATFDSRLSACRTVAQLHRQELPKPVRRVVRLLLQLEQPGEEDQGLPQPPNPAQLLEP 839
             |.......|.....|.....||..:|....|::....|.::  :|.:     |:||.||:    
  Fly  1674 TLRSKNKQYTSGVNKSLSTDFAQQRQQRNSNPMQSGDNLFVR--KPLK-----PKPPVPAK---- 1727

  Fly   840 MFSNLLLPFPSHYMAVYALVRSLHAFE---------ANAVLLELQTHFSCKGGRECERYTEMDRQ 895
                           .:.||.:|...|         ..|.:::...|...|..:|.:|..|..| 
  Fly  1728 ---------------PHNLVSTLSHMEKQQKQKSQSRTASVVQQFEHNLQKFEKEKQREREQQR- 1776

  Fly   896 RVLFERKIAE------CKVMSCCAHVKRLLEPMSFAYEQFTPVELLLPHIIDLLRDERTSILTAW 954
            |......::.      ....||...|.|.  ..|.:..:.|.|.          :..|..|...:
  Fly  1777 RPAMRSSVSSGALAGGSTTQSCLKKVSRF--DTSESSRRATSVR----------QKNRPKISVRF 1829

  Fly   955 NLFDPIAQALGVSQTQQHLLQ--PLLKLYDVESVSSPDDGG---------SNGSTNSGGHLRFSA 1008
            |....|.......:.:|...:  |     ::|..|.|.|.|         .||          :|
  Fly  1830 NTVSQIKYTPSAKRERQAREEEPP-----EMEVGSLPSDYGERSFEMYFAENG----------NA 1879

  Fly  1009 SSSFKSRKSVKLYHHSFLLRLI-----VRFGLRCFLHHFIAPLIEAVGGYKEPEQGNGYHYHSGG 1068
            ..:.::.:::|||....|..::     .|...|..|.:  |..|...||     .|.|   ...|
  Fly  1880 PENLENMQTLKLYTKPQLQAVVDEIQQEREKYRKNLDN--AGKISGKGG-----SGKG---KGAG 1934

  Fly  1069 SRRTSKNLNFA------------SENEVHQTEVAPE--MKP--------DIEELFTFEDD----- 1106
            |..:.:..|.|            .||::.|..:|.|  ::|        ...:..|...|     
  Fly  1935 SSTSHQCQNIAKKIDIIEKLIAMEENKMEQIRLATESRLRPFNCNAKEKGYVKSLTMNFDMLARG 1999

  Fly  1107 HDRASTQDSKSIDSFDMRPSTSAASAEEARESDGSPDKLVINEL--IY---GARISPDKLSLKES 1166
            .|....:|..|.|:.|:     .|.|...|.:...||.|...:.  ||   |..::.:.::..||
  Fly  2000 EDPTEDEDLASKDASDL-----CAYARNIRRNCSLPDVLESTDFTGIYNSQGVELAKEVIADDES 2059

  Fly  1167 QTPPALVPPPIGPRS-------PTIEIPMGPTAGGIRRSFQLSAIDCDIGSRKSVDSFDLISQAV 1224
            ..|   |.|.|...|       .|:.:.|.|                  |:.|:::         
  Fly  2060 GDP---VNPGITADSADHDGIGQTVVLRMEP------------------GNPKTLN--------- 2094

  Fly  1225 EQLPPPAEESEAEASDSLQASVISRLSEAKAVQNNRISEMSAESLVWLSHRLGPVLTSRFITRNL 1289
               |.|.|||....:.||....:....:....||....:...:      ||.|.|..|. ..||.
  Fly  2095 ---PMPIEESSIRRACSLSDLHMGNFGKPGKSQNGTPQKPQVQ------HRNGNVSRSA-SKRNS 2149

  Fly  1290 LK----------LLSLCYVGQENLLPEVDD--------GGSSFNSSPDAANLNYFSIAN 1330
            |:          .:::...|.::   |.:|        .|...::.|.|||..|.:..|
  Fly  2150 LQGKTGLGASSNSMNVLNQGSDS---EPEDSNRLRSASNGQGRSNGPIAANRQYSNKIN 2205

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Wdr81NP_609535.1 Beach 345..588 CDD:100117 56/325 (17%)
WD40 1651..1876 CDD:475233
WD40 repeat 1662..1705 CDD:293791
WD40 repeat 1710..1744 CDD:293791
WD40 repeat 1752..1788 CDD:293791
WD40 repeat 1799..1836 CDD:293791
Wdr62NP_001259886.1 WD40 <73..236 CDD:441893
WD40 repeat 73..107 CDD:293791
WD40 repeat 113..161 CDD:293791
WD40 156..573 CDD:475233
WD40 repeat 167..207 CDD:293791
WD40 repeat 209..285 CDD:293791
WD40 repeat 303..338 CDD:293791
WD40 repeat 353..407 CDD:293791
WD40 <437..750 CDD:441893 9/50 (18%)
WD40 repeat 505..540 CDD:293791
WD40 repeat 546..586 CDD:293791
WD40 repeat 591..631 CDD:293791
WD40 repeat 637..672 CDD:293791
WD40 repeat 679..717 CDD:293791
WD40 repeat 723..749 CDD:293791 8/49 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Software error:

Can't use an undefined value as an ARRAY reference at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 1034.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - -
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.