DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr81 and Wdr62

DIOPT Version :9

Sequence 1:	NP_609535.1	Gene:	Wdr81 / 34616	FlyBaseID:	FBgn0032395	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	NP_001259886.1	Gene:	Wdr62 / 33367	FlyBaseID:	FBgn0031374	Length:	2397	Species:	Drosophila melanogaster

Alignment Length:	1684	Identity:	313/1684 - (18%)
Similarity:	509/1684 - (30%)	Gaps:	576/1684 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DPQHVCEAGGDGRFQVICDKAWLQSLERNRRLTHFPSWPLLDRRSYPIGQLEHPWTRILVQTYRK 78
            |.:|:..|.|||     |...|                           |:.|.   ::|....:
  Fly   731 DCRHLISASGDG-----CIFIW---------------------------QVPHD---MIVTMQAR 760

  Fly    79 QPQSRV----YPLPR----------ISGDAPSSELPLSYSQAVSFVAH--SNFKQLWEEAYRKY- 126
            ..|.|:    .||||          |..::|:||:.....|....||.  |:..||.:.|.||.
  Fly   761 MSQQRLRSGHAPLPRPLAPISPPDGIVLESPTSEIEQPQLQPKFGVAERFSDVGQLPQWAMRKAA 825

  Fly   127 ----NGAHVRMCRSTPSAPSTKPP-----SGQGQL------QPHDVVLKELIQRVYRCPVLHCQL 176
                :||   :...|||..|...|     |..|.|      |...:..:...:...|...|....
  Fly   826 ADSDSGA---LSIPTPSGGSATVPGMHAASSMGNLSSSPSQQMTGLAPRARGRWAQRSTQLETAD 887

  Fly   177 DRDGVSDSSNATSCSAGSCHANVLPALVAIETSTHISVFFYPPALECSLYDCITFSPALL----- 236
            |....|:|...|..|.|. |:.     |.::||.:.|         .|..| ||::...|
  Fly   888 DLRSNSESPLGTVSSVGG-HSG-----VNVQTSDYNS---------ASSKD-ITYNQTYLSEDSS 936

  Fly   237 ---------------GKNYNKTLFVIYQILQLAKHLQ------GQGLFLGDLRLQDIVLRENLWL 280
                           |.:.|.|:..:..:..:|....      |.|.....|:|.|..|:..|
  Fly   937 IDSGMETRRGELKFIGSSNNGTVVTVSSVSSIAVSASNGAMSTGSGAAQQRLQLPDKRLKPGL-- 999

  Fly   281 QVLPRLQCNLLDDDPAGEDMS-----------------PLTP------LVSEDLGEAREA----- 317
                |...:..|.|...||:|                 |.||      .::||  |.|::
  Fly  1000 ----RFDTHTHDHDGDVEDISDGERTSSDHGMFYNNLAPSTPTDFKVTAMNED--ELRKSVRRQK 1058

  Fly   318 -----QQALPS----------SSTMFDLRFAYD----PAHFNLREYTEMWCNGQLSNFDYLTILN 363
                 .|..||          :||........|    |:..|..........|...|..
  Fly  1059 FEKSGLQLTPSALSGNGSSHTASTGTGTSDTEDEGSTPSAENAERSLASTLGGSSENLP------ 1117

  Fly   364 NACGRSLTNAAYHHIM---PWVTDFSGRGGGAWRD------------------LTKS-------- 399
                :|.||:..|..:   |.:|....|||.:.|.                  :|||
  Fly  1118 ----QSSTNSFLHAALPEGPGLTTPMERGGSSRRSISAKHNTENGKSVAAPPTITKSYTSTKKEE 1178

  Fly   400 --------KYRLNKG-------------DV-HLDLMYAHA----SQHGSADGSYQAIGD----QA 434
                    |.:|..|             :| |..|..:|:    |...:.|||..|.|.    |.
  Fly  1179 LLQVINKVKQQLENGTRKNGNTRLNAIAEVGHRPLRGSHSISDLSLAANLDGSRNAGGGPGRYQK 1243

  Fly   435 P---HHVSDFLS-EITYFVYMARRTPQSILCAHVRPIWVPAE-YPVSIQRLQEWTPDECIPEFYS 494
            |   |..|.:.| :.|........|.|.|.....:...:|.| :..:.|:.|::.| ....:|::
  Fly  1244 PVDSHDTSQYTSPQNTTATAAPTNTQQQIQPPVQQQYQIPKEPHQQAQQQHQQYAP-PASQQFFN 1307

  Fly   495 DPMIFKSIHEDLPDLELPAWATCPEDFICKHREALESQYVSERLHHWIDLNFGYKLSGK-AAVKS 558
            .......:.::...:..          :.:|...........::|....:.||...:|. :|::|
  Fly  1308 CAAPKSKLQQNFQTMRQ----------VQQHYPPYPHHVGVHQIHPPPGVPFGGSAAGSTSAMRS 1362

  Fly   559 KNVCLTLVDQHRNLSQR-------------GIVQLFAS-----AHPPRRYATPWFSRTA----PR 601
            .:.......|.:...||             .|::.:.|     .|....::.....|.|    |:
  Fly  1363 HSQPQNRQQQQQQQQQRAKRNPAGNNRRTPSILKHYKSCPVSPVHEEVEWSAEGNERGALLGEPK 1427

  Fly   602 LSQLYASPAK---------------RLAKSTENLQAESATGSSHLSLRLGDDGSSGSVHSSSASA 651
            ...:||..|:               .:.:...:|.......|..:...|.:.|..||...|:.:.
  Fly  1428 RHSVYADDARTILDMIHADTEKMIDEITRKYGDLDEPGIPASYSMPANLRNLGGLGSTGDSTPTG 1492

  Fly   652 SASNFYAITNF------IELPENYNPALLLHNLETLEAFYARTFPQQRASANPEEKMISSDLMFE 710
            ..:.:|....|      :.|.:...|.....:...|:.  ||....||.|:       :|..:..
  Fly  1493 RTTQYYVYREFYQCERKVSLSDILQPEQFAASQRRLDE--ARFLETQRHSS-------ASFFLTG 1548

  Fly   711 QNSAEHSFTNQLFASGDELPPKS-----KNLLREKRNCL-------QHLLNVRKERDLHVLGCLI 763
            |.|.|   :..|.:.||  .|.|     :::|.::.:|.       |..:.|.::|...:...:|
  Fly  1549 QQSQE---SLSLLSDGD--GPGSYCNSLESVLSDESDCQSAPLEYPQTQVAVLQQRHAGIRNFII 1608

  Fly   764 ----------------------------------IELFAMQRLRPL------------------- 775
                                              :..:.::.|:||
  Fly  1609 HGPVSKSYGNSPNAYGSFDYYMRQQHSTTTDSFDVTGYNLEPLKPLPSSKTYPRIAQVQASENIP 1673

  Fly   776 -LMGNGLTATFDSRLSACRTVAQLHRQELPKPVRRVVRLLLQLEQPGEEDQGLPQPPNPAQLLEP 839
             |.......|.....|.....||..:|....|::....|.::  :|.:     |:||.||:
  Fly  1674 TLRSKNKQYTSGVNKSLSTDFAQQRQQRNSNPMQSGDNLFVR--KPLK-----PKPPVPAK---- 1727

  Fly   840 MFSNLLLPFPSHYMAVYALVRSLHAFE---------ANAVLLELQTHFSCKGGRECERYTEMDRQ 895
                           .:.||.:|...|         ..|.:::...|...|..:|.:|..|..|
  Fly  1728 ---------------PHNLVSTLSHMEKQQKQKSQSRTASVVQQFEHNLQKFEKEKQREREQQR- 1776

  Fly   896 RVLFERKIAE------CKVMSCCAHVKRLLEPMSFAYEQFTPVELLLPHIIDLLRDERTSILTAW 954
            |......::.      ....||...|.|.  ..|.:..:.|.|.          :..|..|...:
  Fly  1777 RPAMRSSVSSGALAGGSTTQSCLKKVSRF--DTSESSRRATSVR----------QKNRPKISVRF 1829

  Fly   955 NLFDPIAQALGVSQTQQHLLQ--PLLKLYDVESVSSPDDGG---------SNGSTNSGGHLRFSA 1008
            |....|.......:.:|...:  |     ::|..|.|.|.|         .||          :|
  Fly  1830 NTVSQIKYTPSAKRERQAREEEPP-----EMEVGSLPSDYGERSFEMYFAENG----------NA 1879

  Fly  1009 SSSFKSRKSVKLYHHSFLLRLI-----VRFGLRCFLHHFIAPLIEAVGGYKEPEQGNGYHYHSGG 1068
            ..:.::.:::|||....|..::     .|...|..|.:  |..|...||     .|.|   ...|
  Fly  1880 PENLENMQTLKLYTKPQLQAVVDEIQQEREKYRKNLDN--AGKISGKGG-----SGKG---KGAG 1934

  Fly  1069 SRRTSKNLNFA------------SENEVHQTEVAPE--MKP--------DIEELFTFEDD----- 1106
            |..:.:..|.|            .||::.|..:|.|  ::|        ...:..|...|
  Fly  1935 SSTSHQCQNIAKKIDIIEKLIAMEENKMEQIRLATESRLRPFNCNAKEKGYVKSLTMNFDMLARG 1999

  Fly  1107 HDRASTQDSKSIDSFDMRPSTSAASAEEARESDGSPDKLVINEL--IY---GARISPDKLSLKES 1166
            .|....:|..|.|:.|:     .|.|...|.:...||.|...:.  ||   |..::.:.::..||
  Fly  2000 EDPTEDEDLASKDASDL-----CAYARNIRRNCSLPDVLESTDFTGIYNSQGVELAKEVIADDES 2059

  Fly  1167 QTPPALVPPPIGPRS-------PTIEIPMGPTAGGIRRSFQLSAIDCDIGSRKSVDSFDLISQAV 1224
            ..|   |.|.|...|       .|:.:.|.|                  |:.|:::
  Fly  2060 GDP---VNPGITADSADHDGIGQTVVLRMEP------------------GNPKTLN--------- 2094

  Fly  1225 EQLPPPAEESEAEASDSLQASVISRLSEAKAVQNNRISEMSAESLVWLSHRLGPVLTSRFITRNL 1289
               |.|.|||....:.||....:....:....||....:...:      ||.|.|..|. ..||.
  Fly  2095 ---PMPIEESSIRRACSLSDLHMGNFGKPGKSQNGTPQKPQVQ------HRNGNVSRSA-SKRNS 2149

  Fly  1290 LK----------LLSLCYVGQENLLPEVDD--------GGSSFNSSPDAANLNYFSIAN 1330
            |:          .:::...|.::   |.:|        .|...::.|.|||..|.:..|
  Fly  2150 LQGKTGLGASSNSMNVLNQGSDS---EPEDSNRLRSASNGQGRSNGPIAANRQYSNKIN 2205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117	56/325 (17%)
		WD40	<1644..1877	CDD:225201
		WD40	1651..1876	CDD:295369
		WD40 repeat	1662..1705	CDD:293791
		WD40 repeat	1710..1744	CDD:293791
		WD40 repeat	1752..1788	CDD:293791
		WD40 repeat	1799..1836	CDD:293791
Wdr62	NP_001259886.1	WD40	73..448	CDD:295369
		WD40 repeat	73..107	CDD:293791
		WD40 repeat	113..161	CDD:293791
		WD40	158..574	CDD:225201
		WD40 repeat	167..207	CDD:293791
		WD40 repeat	209..285	CDD:293791
		WD40 repeat	254..294	CDD:293791
		WD40 repeat	303..338	CDD:293791
		WD40 repeat	353..407	CDD:293791
		WD40	385..747	CDD:225201	7/20 (35%)
		WD40	436..748	CDD:295369	8/48 (17%)
		WD40 repeat	505..540	CDD:293791
		WD40 repeat	546..586	CDD:293791
		WD40 repeat	591..631	CDD:293791
		WD40 repeat	637..672	CDD:293791
		WD40 repeat	679..717	CDD:293791
		WD40 repeat	723..749	CDD:293791	8/49 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442359
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930