DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr81 and Nbeal2

DIOPT Version :9

Sequence 1:	NP_609535.1	Gene:	Wdr81 / 34616	FlyBaseID:	FBgn0032395	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	XP_003750638.1	Gene:	Nbeal2 / 316014	RGDID:	1306501	Length:	2752	Species:	Rattus norvegicus

Alignment Length:	1071	Identity:	233/1071 - (21%)
Similarity:	372/1071 - (34%)	Gaps:	312/1071 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 RLTHFPSWPLLDRRSYPIGQLEHPWTRILVQTYRKQPQSRVYPLPRISGDAP-----SSELPLSY 103
            |:...|.|.|....:|...:|:      ||..:...|......|....|:||     .:.|||:.
  Rat  1818 RVPPTPHWKLSSAETYSRMRLK------LVPNHHFDPHLEASALRDNLGEAPMTPTEEASLPLAV 1876

  Fly   104 SQAVSFVAHSNFKQLWEEAYRKYNGAHVRMCRSTPSAPSTKPPSG--QGQLQPHDVVLKELIQRV 166
                                             |..|..:.||..  :.||...::.:.|.:...
  Rat  1877 ---------------------------------TKEAKISAPPEELLEDQLGEEELAVLETLMEA 1908

  Fly   167 YRCPVLHCQLD--RDGVSDSSNATSCSAGSCHANVLPALVAIETSTHISVFFYPPALECSLYDCI 229
                   .:||  |:.:..|:   .|...:..| |:|.|:.: |:.|  |:||..:.|      .
  Rat  1909 -------AELDEQREKLVLSA---ECQLVTVVA-VVPGLLEV-TTQH--VYFYDGSTE------R 1953

  Fly   230 TFSPALLGKNYNKTLFVIYQILQLAKHLQGQGLFLGDLRLQDIVLRENLWLQVLPRLQCNLLDDD 294
            ..:...:|.::.:.|..:.::     ||:...|....|.| ..:.:.|.:|....::
  Rat  1954 VETEEGIGHDFRRPLAQLREV-----HLRRFNLRRSALEL-FFIDQSNYFLNFPHKV-------- 2004

  Fly   295 PAGEDMSP--------LTPL---------VSEDLGEAREAQQALPSSSTMFDLRFAYDPAHFNLR 342
             ||...||        |.|:         |...|...|...|...||.:..::          ||
  Rat  2005 -AGASASPPCQAPRPQLYPIPPHTQVRNQVYSLLLRLRPPTQGYLSSRSPQEM----------LR 2058

  Fly   343 E--YTEMWCNGQLSNFDYLTILNNACGRSLTNAAYHHIMPWV-TDFSG-----RGGGAWRDLTKS 399
            .  .|:.|...::|||:||..||...||:..:.:.:.:.||| .|:..     .....:|||:|.
  Rat  2059 ASGLTQKWVQREISNFEYLMQLNTIAGRTYNDLSQYPVFPWVLQDYVSPVLDLNNPAVFRDLSKP 2123

  Fly   400 KYRLNKGDVHLDLMYAHASQHGSADGSYQAIGDQAP-----HHVSDFLSEITYFVYMARRTPQSI 459
            ...:|  ..|..|:..          .|::..|.|.     |:.:.:.:......|:.|..|.:.
  Rat  2124 IGVVN--PKHAQLVRE----------KYESFEDPAGTIDKFHYGTHYSNAAGVMHYLIRVEPFTS 2176

  Fly   460 L----------CA-----HVRPIW-VPAEYPVSIQRLQEWTPDECIPEFYSDPMIFKS------- 501
            |          |:     .|...| ...|.|..::        |.||||:..|...::
  Rat  2177 LHVQLQSGRFDCSDRQFHSVAAAWQARLESPADVK--------ELIPEFFYFPDFLENQNGFDLG 2233

  Fly   502 ----IHEDLPDLELPAWATCPEDFICKHREALESQYVSERLHHWIDLNFGYKLSGKAAVKSKNV- 561
                .:|.:.|:.||.||:.|||||.|||.||||:|||..||.||||.||||..|.||.::.||
  Rat  2234 CLQLTNEKVGDVVLPPWASSPEDFIQKHRRALESEYVSTHLHEWIDLIFGYKQRGPAAEEALNVF 2298

  Fly   562 --CL--------TLVDQHRNLSQRGIV--------QLFASAHPPRRYATPWFSRTAPRLSQLYA- 607
              |.        .:.|:....:..||:        ||....||||..|    ...|.||::|..
  Rat  2299 YYCTYEGAVDLDHVADERERKALEGIISNFGQTPCQLLKEPHPPRLSA----EEAAIRLARLDTH 2359

  Fly   608 SPAKRLAKSTENLQ---AESATGSSHLSLRLGDDGSSGSVHSSSAS-----ASASNFYAITNFIE 664
            ||:  :.::.:.|:   ||..:....|.|.|.....:.|..:.|||     .|||......:::.
  Rat  2360 SPS--IFQNLDQLKAFFAEVVSEGVPLLLALVPHRQTHSFITQSASDMLVTVSASGLLGTHSWLP 2422

  Fly   665 LPENYNPALLLHNLETLEAFYARTFPQQRASANPE-EKMISSDLMFEQNSAEHSFT----NQLFA 724
            ...|.|...              :|.:.....||: :|::|............:..    .:|..
  Rat  2423 YDRNINNYF--------------SFSKDPTMGNPKVQKLLSGPWAPGSGVRGQALAVAPDGKLLF 2473

  Fly   725 SGDELPPKSKNLLREKRNCLQHLLNVRKERDLHVLGCLIIE---LFAMQRLRP-------LLMGN 779
            ||.......:..|..:...|..|     .|.|.|:.||.::   ::.:...|.       ||..|
  Rat  2474 SGGHWDGSLRVTLLSRGRLLSQL-----SRHLDVVTCLALDTCGIYLISGSRDTTCMVWRLLQQN 2533

  Fly   780 GLTATFDSRLSACRTVAQLHRQELPKPVRRV-----------VRLLLQLEQPGEED--------- 824
            ||:|..                 .||||:.:           :...|.:...|.||
  Rat  2534 GLSAGL-----------------APKPVQVLYGHEAAVSCVAISTELDMAVSGSEDGTVIIHTVR 2581

  Fly   825 ----QGLPQPPNPAQLLEPMFSNLLLPFPSHYMAVYA---LVRSLHAFEANAVLLELQTHFSCKG 882
                ....:||...           ||.|..::|:.:   :|....|.|.....:....|.....
  Rat  2582 RGQFVAALRPPGAT-----------LPGPISHLALGSEGQIVVQSSACERPGAQVTYSLHLYSVN 2635

  Fly   883 GRECERYTEMDRQRVLFERKIAECKVM----SCCAHVKRL--LEPMSFAYEQFTPVELLLP-HII 940
            ||.....|..::...|   .:||..|:    .|..|:..|  |.|      ...|:.:.:| |.:
  Rat  2636 GRLRASLTLTEQPTAL---TVAEDFVLLGTAQCSLHILHLNKLRP------AVPPLPMKVPVHSV 2691

  Fly   941 DLLRDERTSILTAWNLFDPIAQALGVSQTQQ 971
            .:.: ||:.:|.  .|.|.....:|..|..:
  Rat  2692 SVTK-ERSHVLV--GLEDGKLIVVGAGQPSE 2719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117	85/299 (28%)
		WD40	<1644..1877	CDD:225201
		WD40	1651..1876	CDD:295369
		WD40 repeat	1662..1705	CDD:293791
		WD40 repeat	1710..1744	CDD:293791
		WD40 repeat	1752..1788	CDD:293791
		WD40 repeat	1799..1836	CDD:293791
Nbeal2	XP_003750638.1	DUF4704	878..1127	CDD:292415
		DUF4800	1593..1859	CDD:292675	10/46 (22%)
		PH_BEACH	1916..2041	CDD:275391	29/152 (19%)
		Beach	2064..2343	CDD:280327	84/298 (28%)
		WD40	<2461..2711	CDD:225201	56/294 (19%)
		WD40 repeat	2461..2498	CDD:293791	6/41 (15%)
		WD40	2462..2711	CDD:295369	56/293 (19%)
		WD40 repeat	2504..2549	CDD:293791	13/61 (21%)
		WD40 repeat	2554..2590	CDD:293791	4/35 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010