DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr81 and Wdr81

DIOPT Version :9

Sequence 1:	NP_609535.1	Gene:	Wdr81 / 34616	FlyBaseID:	FBgn0032395	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	XP_038941944.1	Gene:	Wdr81 / 303312	RGDID:	1311334	Length:	1944	Species:	Rattus norvegicus

Alignment Length:	2161	Identity:	667/2161 - (30%)
Similarity:	970/2161 - (44%)	Gaps:	472/2161 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EIGVDPQHVCEAGGDGRFQVICDKAWLQSLERNRRLTHFPS---------WPLLDRRSYPIGQLE 65
            ::.:|.:.:..|.|......:....||.|| |.|||...|.         ..||.|   .:.:|.
  Rat    37 DLNIDARQLALAPGGTHVVALVSTRWLASL-RERRLGPCPRAEGLGEAEVRTLLQR---SVQRLP 97

  Fly    66 HPWTRILVQTYRKQPQSRVYPLPRISGDAPSSELPLSYSQAVSFVAHSNFKQLWEEAYRKYNGAH 130
            ..|||:.|...||:..|  |||.|:......|..|.:.::.:..||..|::.||..||..|...:
  Rat    98 QGWTRVEVHGLRKRRLS--YPLSRVLPFEEGSCSPETLTRFMQEVAAQNYRNLWRHAYHTYGQPY 160

  Fly   131 VRMCRSTPSAPSTKPPSGQGQLQPHDVVLKELIQRVYRC---PV---LHCQLD-RDGVSDSSNAT 188
                 |..:|||..|....         :::.:||||.|   ||   :.|..: |||.|..|:|
  Rat   161 -----SHSTAPSAIPALDS---------IRQALQRVYGCTFLPVGESMQCLSNVRDGPSRGSSA- 210

  Fly   189 SCSAGSCHANVLPALVAIETSTHISVFFY--PPALECSLYDCITFSPALLGKNYNKTLFVIYQIL 251
                  |     |:|:..|.........|  .|.::.||:|.:|||||.|..:..|.||:::::|
  Rat   211 ------C-----PSLLRAEALLESPEMLYVVHPYVQFSLHDVVTFSPAKLTNSQAKVLFILFRVL 264

  Fly   252 QLAKHLQGQGLFLGDLRLQDIVLRENLWLQVLPRLQCNLLDDDPAGEDMS---PLTPLVSEDLGE 313
            :.......|||..|.|.|..|.:.|.|..::...|....:..:...:::|   ..|.:.||..||
  Rat   265 RAMDACHRQGLACGALSLHHIAVDEKLCSELRLDLSAYEMPSEDENQEVSEEKDRTGVKSEKDGE 329

  Fly   314 AREAQQALPSSSTMFDLRFAYDPAHFNLREYTEMWCNGQLSNFDYLTILNNACGRSLTNAAYHHI 378
            .|      |...|          ....||.....|.:|::|||.||..||...||...:..||.:
  Rat   330 GR------PGCPT----------CQKELRGLVLDWVHGRVSNFYYLMQLNRLAGRRQGDPNYHPV 378

  Fly   379 MPWVTDFSGRGGGAWRDLTKSKYRLNKGDVHLDLMYAHASQHGSADGSYQAIGDQAPHHVSDFLS 443
            :|||.||: ...|.:|||.|||:||||||..||..|....|...|.|:........|||:||.||
  Rat   379 LPWVVDFT-TPYGRFRDLRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGSGEPLHVPHHISDVLS 442

  Fly   444 EITYFVYMARRTPQSILCAHVRPIWVPAEYPVSIQRLQEWTPDECIPEFYSDPMIFKSIHEDLPD 508
            :|||:||.|||||:|:||.|||..|.|.|||.:::|:|.|||||||||||:||.||.|||.|:||
  Rat   443 DITYYVYKARRTPRSVLCGHVRAQWEPHEYPATMERMQTWTPDECIPEFYTDPSIFCSIHPDMPD 507

  Fly   509 LELPAWATCPEDFICKHREALESQYVSERLHHWIDLNFGYKLSGKAAVKSKNVCLTLVDQHRNLS 573
            |::|||.:..::|:..||..|||..||:.|||||||.|||||.||.|||.|||||.|||.|.:|:
  Rat   508 LDVPAWCSSNQEFVTAHRALLESWEVSQDLHHWIDLTFGYKLQGKEAVKEKNVCLHLVDAHTHLT 572

  Fly   574 QRGIVQLFASAHPPRRYATPWFSRTAPRLSQLYASPAKRLAKSTENL------------------ 620
            ..|:||||...||.|....|..:...|.:.:|...|.:. |...|::
  Rat   573 SYGVVQLFDQPHPQRLAGAPALAPEPPLIPRLLVQPIQE-ATGQEDISGQLINGAGRHVVEVTPC 636

  Fly   621 -----------------QAESATGSSHLSLRLGDD-GSSGSVHSSSASASASNFYAITNF----- 662
                             ||..|..|..:..:.||. |||    ||.||.....|.|.:..
  Rat   637 ESGWTRERPTAGEDDLEQATEALDSISIPGKAGDQPGSS----SSQASPGLLPFSAPSGSRPGRR 697

  Fly   663 ---------------IELPENYNPALLLHNLETLEAFYARTFPQQRASANPEEKMISSDLMFEQN 712
                           |.|||.::|...|..||.:..|.||....|  ...||:....
  Rat   698 SKATGLDSGEGDEGKIVLPEGFSPIQALEELEKVGNFLARGLGSQ--LEEPEKPQAQ-------- 752

  Fly   713 SAEHSFTNQLFASGDELPPKSKNLLREKRNCLQHLLNVRKERDLHVLGCLIIELFAMQRLRPLLM 777
                             ||.          .||.|.:    ||:.|||.|:.|:....|:|.|..
  Rat   753 -----------------PPV----------YLQSLFH----RDMQVLGVLLAEMVFATRVRILQP 786

  Fly   778 GNGLTATFDSRLSACRTVAQLHRQELPKPVRRVVRLLLQLEQP--------GEED---------Q 825
            ...|...|:    |.|.:...|.:::|..::.|:..||||..|        |:.|         |
  Rat   787 DAPLWVRFE----AVRGLCTRHSKDIPVSLQPVLDTLLQLSGPKSPLVVKKGKLDPLFEYRPVSQ 847

  Fly   826 GLPQPPNPAQLLEPMFSNLLLPFPSHYMAVYALVRSLHAFEANAVLLELQTHFSCKGGRECERYT 890
            ||| ||:|||||.|..|  ::|||:::.|::..:.   .::|..|..|:|       |||.
  Rat   848 GLP-PPSPAQLLSPFSS--VVPFPTYFPALHKFIL---LYQARRVEDEVQ-------GREL---- 895

  Fly   891 EMDRQRVLFERKIAECKVMSCCAHVKRLLEPMSFAYEQFTP--VELLLPHIIDLLRDERTSILTA 953
                                    |..|.:.:.....:.||  :|:|||.::.|:.:|.|::.||
  Rat   896 ------------------------VFALWQQLGAVLNEITPEGLEILLPFVLSLMSEEHTAVYTA 936

  Fly   954 WNLFDPIAQALGVSQTQQHLLQPLLKLYDVESVSSPDDGGSNGSTNSGGHLRFSASSSFKSRKSV 1018
            |.||:|:|:|||...|.::||:||:..|:     :|          ...|.||
  Rat   937 WYLFEPVAKALGPKNTIKYLLKPLIGAYE-----NP----------CRLHGRF------------ 974

  Fly  1019 KLYHHSFLLRLIVRFGLRCFLHHFIAPLIEAVGGYK-EPEQGNGY-------------------- 1062
            .||...|:.:|:||.||:.||.|.:..:::.:.|.: ..|:|.|.
  Rat   975 YLYTDCFVAQLVVRLGLQAFLIHLLPHVLQVLAGVEASQEEGKGLVGTTEDEENELPVPGPGSCA 1039

  Fly  1063 ---HYHSGGSRRTSKNLNFASENEVHQTEVAPEMKPDIEELFTFEDDHDRASTQDSKSIDSFDMR 1124
               ....||....|..|..                ||.....:|   ||:|...|::     |.:
  Rat  1040 FGEEIQMGGQPAASSGLGL----------------PDYRSGVSF---HDQADLPDTE-----DFQ 1080

  Fly  1125 PSTSAASAEEARESDGSPDKLVINELIYGARISPDKLSLKESQTPPALVPPPIGPRSPTIEIPMG 1189
            .....|.:.:.:|::.               :|..:||.|.|                |.|...|
  Rat  1081 AGLYVAESPQPQEAEA---------------VSLGQLSDKSS----------------TSEASQG 1114

  Fly  1190 PTAGGIRRSFQLSAIDCDIGSRKSVDSFDLISQAVEQLPPPAEESEAE----------------A 1238
            ...||     .......|..|.||.||    ||.::|.....||.|.|                .
  Rat  1115 EERGG-----DDGGAPVDKNSVKSGDS----SQDLKQSEGSEEEEEEEEGCVVLEEEEQDEVTGT 1170

  Fly  1239 SDSLQASVISRLSEAKAVQNNRISEMSAESLV--------------------WLSHRLGPVLTSR 1283
            |:...:..|..:....|..:.|..|...|.|.                    |||.:|||.:.||
  Rat  1171 SELTLSDTILSMETVVAPGDGRDREEEEEPLPEQTEGKEQKILLDTACKMVRWLSAKLGPTVASR 1235

  Fly  1284 FITRNLLKLLSLCYVG--QENLLPEVDDGGSSFNSSPDAANLNYFSIANAR-VVGDRSAARVLEC 1345
            .:.||||:||:.||||  ::......||       ||.   ||..:|...| |:||..:..||.|
  Rat  1236 HVARNLLRLLTSCYVGPTRQQFTVSCDD-------SPP---LNAGNIYQKRPVLGDIVSGPVLSC 1290

  Fly  1346 LMSIAALYGENFLLLQYFPHISELISLCS----KRITGSLEGAIISSLQLLKYMVPCLTDASIME 1406
            |:.||.||||..|..||.|:||.|::..|    .|:....|..:::::.|.:.::..|:|.::|:
  Rat  1291 LLHIAHLYGEPVLTYQYLPYISYLVAPGSNSSPSRLNSRKEAGLLAAVTLTQKIIVYLSDTTLMD 1355

  Fly  1407 HLQHIMLDAILLPILRLLSSTNLVMPSGYLGRSLLARKFLDAIYALSVRLGSDMTREHLCQPLLN 1471
            .|..|..: :|||:|..|:|.....|||...|::|..|.:..|..:.:|:|.:|.::||.:|:..
  Rat  1356 ILPRISHE-VLLPVLSFLTSFVTGFPSGAQARTVLCVKTISLIALICLRIGQEMVQQHLSEPVAT 1419

  Fly  1472 PFFLIFNKAFGL-PNDFACD--------LANLSLVGGASQP--ERALEELRDVFGPELAHTAYLT 1525
             ||.:|:....| ..|...|        |...:...|..:|  ...||||:.||..|:|:|.|:.
  Rat  1420 -FFQVFSHLHELRQQDLQLDLKGCTEGQLPEATFSDGQRRPVDPTLLEELQKVFTLEMAYTIYVP 1483

  Fly  1526 FLRFLGEAN----------MKRTLSNLDFVLTLCHEHEQPNGQSKIQLATNV-----SSGQDVDS 1575
            |...||.|:          :::.:.|.:.|..|...:.:....|.::...::     |:|.:.:.
  Rat  1484 FSCLLGIAHHVPLHRVGDIIRKIIPNHELVGELAGLYLESMSPSSLRNPASMEPVTPSAGPEWNP 1548

  Fly  1576 VDASC---ELAANSFGTQIVGNRLQV-----------------------ARNNVELIDMVAYKLD 1614
            ...||   :..:.:||:.:||||:|:                       :||....:..
  Rat  1549 QSGSCLQDDGHSGTFGSVLVGNRIQIPDSQPQSSGPLGSISGVGSGGLSSRNEDNALKR------ 1607

  Fly  1615 QMPKTRH-LKGNWLAYWRNETTRNEKDTQTLNLKQIRLQSFVGHTNSVRAIYALDNENSFISASK 1678
            ::|::.| |.|||||||:.|...:::|.. .:..|||||||.|||.:|:.:.||.:|:.|:|.||
  Rat  1608 ELPRSAHGLSGNWLAYWQYEIGVSQQDAH-FHFHQIRLQSFPGHTGAVKCVAALSSEDFFLSGSK 1671

  Fly  1679 DKTVKLWSLRSEGDGRKTSACQFTYTAHKKSINSLGFLESLRYVVSCDSGIHLWDPFIGRPLSVL 1743
            |:||:||.|.:.|||...:|.:..|..|:||:..:|.||:.:||||||..:|:||||.|:.|..:
  Rat  1672 DRTVRLWPLYNYGDGTSETAPRLIYAQHRKSVFYVGQLEAPQYVVSCDGAVHVWDPFTGKTLRTV 1736

  Fly  1744 DAPRHSAV--TVVKCLPSHSPLVIAGTAESTVKMVDARSCEYVNEWRVCNASLPNATVRCLAVAP 1806
            | |..|.|  |.|..:|:....:...:::||::.||.|.....:|:|: ...|....||.|||:|
  Rat  1737 D-PSDSRVPLTAVAVMPAPHTSITMASSDSTLRFVDCRKPGLQHEFRL-GGGLNPGLVRSLAVSP 1799

  Fly  1807 SGNWLAAGLSSGCIVQLDTRTGMVINSWRPMECDLLQLAAPSDQFLVSSALDHSLAVWHALDGIM 1871
            ||..:.||.|||.:|.||||||:|:..|...|.|:||:.|.....:|||:.||||.||..|:...
  Rat  1800 SGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIKAVEGSVIVSSSSDHSLTVWKELEQKP 1864

  Fly  1872 HYQLKPPPEPAHFLQSVGPSLVYATTGNRVGVYADVAHSHAFSTITKLRSETFRGVLTSLAVLPL 1936
            .:..|...:|.|.....|..:|..|..|::|| ..:....:.:| |||.||.|||.|||||:||.
  Rat  1865 THHYKSASDPIHTFDLYGSEVVTGTVANKIGV-CSLLEPPSQAT-TKLSSENFRGTLTSLALLPT 1927

  Fly  1937 NRAFLAGNESGNIALL 1952
            .|..|.|:::|.|.||
  Rat  1928 KRHLLLGSDNGIIRLL 1943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117	134/242 (55%)
		WD40	<1644..1877	CDD:225201	100/234 (43%)
		WD40	1651..1876	CDD:295369	97/226 (43%)
		WD40 repeat	1662..1705	CDD:293791	18/42 (43%)
		WD40 repeat	1710..1744	CDD:293791	16/33 (48%)
		WD40 repeat	1752..1788	CDD:293791	9/35 (26%)
		WD40 repeat	1799..1836	CDD:293791	22/36 (61%)
Wdr81	XP_038941944.1	Beach	347..587	CDD:100117	121/239 (51%)
		WD40	1644..1942	CDD:421866	121/300 (40%)
		WD40 repeat	1655..1698	CDD:293791	18/42 (43%)
		WD40 repeat	1703..1737	CDD:293791	15/33 (45%)
		WD40 repeat	1746..1782	CDD:293791	18/37 (49%)
		WD40 repeat	1792..1825	CDD:293791	8/32 (25%)
		WD40 repeat	1834..1867	CDD:293791	17/32 (53%)
		WD40 repeat	1874..1896	CDD:293791	10/21 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346101
Domainoid	1	1.000	264	1.000	Domainoid score	I1847
eggNOG	1	0.900	-	-		E1_KOG1786
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13983
Inparanoid	1	1.050	785	1.000	Inparanoid score	I495
OMA	1	1.010	-	-		QHG48726
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	1	1.000	-	-		FOG0006096
OrthoInspector	1	1.000	-	-		oto96452
orthoMCL	1	0.900	-	-		OOG6_105710
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4393
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.670