DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr81 and lvs1

DIOPT Version :9

Sequence 1:	NP_609535.1	Gene:	Wdr81 / 34616	FlyBaseID:	FBgn0032395	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	NP_595759.2	Gene:	lvs1 / 2540571	PomBaseID:	SPBC28E12.06c	Length:	2609	Species:	Schizosaccharomyces pombe

Alignment Length:	449	Identity:	117/449 - (26%)
Similarity:	168/449 - (37%)	Gaps:	131/449 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 GQGLFLGDLR-----LQDIVLRENLWLQVLPRLQCNLLDDDPAGEDM---SPLTPLVSEDLGEAR 315
            |..||..|.|     |.:...|::|:.:::.|         ..|.|:   |.....:|.|||:|.
pombe  1841 GLELFFKDGRSFLTILSNTKNRDSLYQKLVAR---------APGADVLSTSHFATSMSRDLGKAN 1896

  Fly   316 EAQQALPSSSTMFDLRFA-YDPAHFNLREYTEMWCNGQLSNFDYLTILNNACGRSLTNAAYHHIM 379
            .....| ||.....|.|: ..||       |:.|...::|||:||.|:|...||:..:...:.:.
pombe  1897 GKSNFL-SSKLANALSFSTTHPA-------TKRWERREISNFNYLQIVNTLAGRTYNDLTQYPVF 1953

  Fly   380 PWVTDFSGRGGGAWRDLTKSKYRLNKGDVHLDLMYAHASQHGSADGSYQAIGD---------QAP 435
            |||.          .|.|..:..||....:.:......:||...:..:....|         |.|
pombe  1954 PWVI----------ADYTSKELDLNNPKTYRNFCKPMGAQHPERESQFNERYDLLLGLNDSQQQP 2008

  Fly   436 HH----------VSDFLSEITYFV--YMARRTPQSILCAHVRPIWVPAEYPVSIQRLQEWTPD-- 486
            .|          |..:|..:..||  |:|.:..|   ..|...::...|        |.|...
pombe  2009 FHYGTHYSSAMIVCSYLIRLRPFVDSYLALQGGQ---FDHADRLFYSIE--------QAWRSSSK 2062

  Fly   487 -------ECIPEFY--SDPMI------FKSIHED---LPDLELPAWAT-CPEDFICKHREALESQ 532
                   |.||||:  |:..|      |.|..::   :.|:.||.||. .|..|:.|:||||||:
pombe  2063 ENMADVRELIPEFFYLSEMFINGNGFDFGSRQKESTPINDVILPPWAKGDPAIFVQKNREALESK 2127

  Fly   533 YVSERLHHWIDLNFGYKLSGKAAVKSKNVCLTLVDQHRNLSQRGIV------------------- 578
            |||..||.||||.||.|..|..||.:.||       ..:||.:|.:
pombe  2128 YVSAHLHEWIDLVFGCKQRGDEAVAATNV-------FHHLSYQGAIDLENIENEFELAAAVGIIH 2185

  Fly   579 -------QLFASAHP---PRRYATP----WFSRTAPRLSQLY--ASPAKRLAKSTENLQ 621
                   |:|...||   |....||    .|.|....:..|:  .||..|:.|...::|
pombe  2186 NFGQTPKQVFKKPHPQRGPDFTDTPLGPYLFGRFEDSIHLLFQSCSPIIRICKKVAHIQ 2244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117	82/313 (26%)
		WD40	<1644..1877	CDD:225201
		WD40	1651..1876	CDD:295369
		WD40 repeat	1662..1705	CDD:293791
		WD40 repeat	1710..1744	CDD:293791
		WD40 repeat	1752..1788	CDD:293791
		WD40 repeat	1799..1836	CDD:293791
lvs1	NP_595759.2	LamG	380..534	CDD:304605
		DUF4704	715..>837	CDD:292415
		PH_BEACH	1738..1871	CDD:275391	8/29 (28%)
		Beach	1919..2202	CDD:214982	82/310 (26%)
		WD40	<2255..2485	CDD:225201
		WD40	2255..>2466	CDD:295369
		WD40 repeat	2255..2294	CDD:293791
		WD40 repeat	2300..2340	CDD:293791
		WD40 repeat	2345..2398	CDD:293791
		WD40 repeat	2406..2435	CDD:293791
		FYVE_like_SF	2556..2600	CDD:277249
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1786
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900