Protein Alignment Wdr81 and Wdr81

DIOPT Version :10

• Sequence 1: NP_609535.1
• Gene: Wdr81 / 34616
• FlyBaseID: FBgn0032395
• Length: 1953
• Species: Drosophila melanogaster
• Sequence 2: XP_006532609.1
• Gene: Wdr81 / 192652
• MGIID: 2681828
• Length: 1945
• Species: Mus musculus
• Alignment Length: 2159
• Identity: 661/2159 - (30%)
• Similarity: 979/2159 - (45%)
• Gaps: 467/2159 - (21%)

  Fly    10 EIGVDPQHVCEAGGDGRFQVICDKAWLQSLERNRRLTHFPS---------WPLLDRRSYPIGQLE 65
            ::.:|.:.:..|.|......:....||.|| |.|||...|.         ..||.|   .:.:|.
Mouse    37 DLNIDARQLALAPGGTHVVALVSTRWLASL-RERRLGPCPRAEGLGEAEVRTLLQR---SVQRLP 97

  Fly    66 HPWTRILVQTYRKQPQSRVYPLPRISGDAPSSE---LPLSYSQAVSFVAHSNFKQLWEEAYRKYN 127
            ..|||:.|...||:..|  |||   .|..|..|   .|.:.::.:..||..|::.||..||..|.
Mouse    98 PGWTRVEVHGLRKRRLS--YPL---GGGVPFEEGSCSPETLTRFMQEVAAQNYRNLWRHAYHTYG 157

  Fly   128 GAHVRMCRSTPSAPSTKPPSGQGQLQPHDVVLKELIQRVYRC---PV---LHCQLD-RDGVSDSS 185
            ..:     |..:|||..|....         :::.:||||.|   ||   :.|..: |||...|.
Mouse   158 QPY-----SHSTAPSALPALDS---------IRQALQRVYGCTFLPVGESIPCLSNVRDGPCPSR 208

  Fly   186 NATSCSAGSCHANVLPALVAIETSTHISVFFY--PPALECSLYDCITFSPALLGKNYNKTLFVIY 248
            .:.:|          |:|:..|.........|  .|.::.||:|.:|||||.|..:..|.||:::
Mouse   209 GSPAC----------PSLLRAEALLESPEMLYVVHPYVQFSLHDVVTFSPAKLTNSQAKVLFLLF 263

  Fly   249 QILQLAKHLQGQGLFLGDLRLQDIVLRENLWLQVLPRLQCNLL-----DDDPAGEDMSPLTPLVS 308
            ::|:.......|||..|.|.|..|.:.|.|..::  ||..:..     |::..|.:....|.:.|
Mouse   264 RVLRAMDACHRQGLACGALSLHHIAVDEKLCSEL--RLDLSAYEMPSEDENQEGSEEKNGTGIKS 326

  Fly   309 EDLGEAREAQQALPSSSTMFDLRFAYDPAHFNLREYTEMWCNGQLSNFDYLTILNNACGRSLTNA 373
            |..||.|   ...|:...             .||.....|.:|::|||.||..||...||...:.
Mouse   327 EKEGEGR---TECPTCQK-------------ELRGLVLDWVHGRISNFHYLMQLNRLAGRRQGDP 375

  Fly   374 AYHHIMPWVTDFSGRGGGAWRDLTKSKYRLNKGDVHLDLMYAHASQHGSADGSYQAIGDQAPHHV 438
            .||.::|||.||: ...|.:|||.|||:||||||..||..|....|...|.|:........|||:
Mouse   376 NYHPVLPWVVDFT-TPYGRFRDLRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGSGEPPHVPHHI 439

  Fly   439 SDFLSEITYFVYMARRTPQSILCAHVRPIWVPAEYPVSIQRLQEWTPDECIPEFYSDPMIFKSIH 503
            ||.||:|||:||.|||||:|:||.|||..|.|.|||.:::|:|.|||||||||||:||.||.|||
Mouse   440 SDVLSDITYYVYKARRTPRSVLCGHVRAQWEPHEYPATMERMQTWTPDECIPEFYTDPSIFCSIH 504

  Fly   504 EDLPDLELPAWATCPEDFICKHREALESQYVSERLHHWIDLNFGYKLSGKAAVKSKNVCLTLVDQ 568
            .|:|||::|||.:..::|:..||..|||..||:.|||||||.|||||.||.|||.|||||.|||.
Mouse   505 PDMPDLDVPAWCSSNQEFVAAHRALLESWEVSQDLHHWIDLTFGYKLQGKEAVKEKNVCLHLVDA 569

  Fly   569 HRNLSQRGIVQLFASAHPPRRYATPWFSRTAPRLSQLYASPAKRLAKSTENLQAESATGSSHLSL 633
            |.:|:..|:||||...||.|...:|..:...|.:.:|...|. |.|...|::..:...|:..|.:
Mouse   570 HTHLTSYGVVQLFDQPHPQRLAGSPALAPEPPLIPRLLVQPI-REATGQEDISGQLINGAGRLVV 633

  Fly   634 R--------------LGDD---------------GSSGSVHSSSASASASNFYAIT--------- 660
            .              .|:|               |.:|....||:|.::....:.:
Mouse   634 EATPCETGWTRDRPGTGEDDLEQATEALDSISLPGKAGDQPGSSSSQASPGLLSFSAPSGSRPGR 698

  Fly   661 --------------NFIELPENYNPALLLHNLETLEAFYARTFPQQRASANPEEKMISSDLMFEQ 711
                          ..|.|||.::|...|..||.:..|.|:....|                .|:
Mouse   699 RSKAAGLDPGEGEEGKIVLPEGFSPIQALEELEKVGNFLAKGLGSQ----------------LEE 747

  Fly   712 NSAEHSFTNQLFASGDELPPKSKNLLREKRNCLQHLLNVRKERDLHVLGCLIIELFAMQRLRPLL 776
            ....|:           .||..          ||.|.:    ||:.|||.|:.|:....|:|.|.
Mouse   748 PEKPHA-----------QPPVH----------LQSLFH----RDMQVLGVLLAEMVFATRVRILQ 787

  Fly   777 MGNGLTATFDSRLSACRTVAQLHRQELPKPVRRVVRLLLQLEQP--------GEED--------- 824
            ....|...|:    |.|.:...|.:::|..::.|:..||||..|        |:.|
Mouse   788 PDAPLWVRFE----AVRGLCIRHSKDIPVSLQPVLDTLLQLSGPKSPMVSKKGKLDPLFEYRPVS 848

  Fly   825 QGLPQPPNPAQLLEPMFSNLLLPFPSHYMAVYALVRSLHAFEANAVLLELQTHFSCKGGRECERY 889
            |||| ||:|||||.|..|  ::|||.::.|::..:.   .::|..|..|:|       |||
Mouse   849 QGLP-PPSPAQLLSPFSS--VVPFPPYFPALHKFIL---LYQARRVEDEVQ-------GRE---- 896

  Fly   890 TEMDRQRVLFERKIAECKVMSCCAHVKRLLEPMSFAYEQFTP--VELLLPHIIDLLRDERTSILT 952
                   :.|                 .|.:.:.......||  :|:|||.::.|:.:|.|::.|
Mouse   897 -------LAF-----------------ALWQQLGAVLNDITPEGLEILLPFVLSLMSEEHTAVYT 937

  Fly   953 AWNLFDPIAQALGVSQTQQHLLQPLLKLYDVESVSSPDDGGSNGSTNSGGHLRFSASSSFKSRKS 1017
            ||.||:|:|:|||.....::||:||:..|:     ||          ...|.||
Mouse   938 AWYLFEPVAKALGPKNANKYLLKPLIGAYE-----SP----------CRLHGRF----------- 976

  Fly  1018 VKLYHHSFLLRLIVRFGLRCFLHHFIAPLIEAVGGYKEPEQGNGYHYHSGGSRRTSKNLNFASEN 1082
             .||...|:.:|:||.||:.||.|.:..:::.:.|.:             .|:...|.|...:|:
Mouse   977 -YLYTDCFVAQLVVRLGLQAFLTHLLPHVLQVLAGVE-------------ASQEEGKGLVGTTED 1027

  Fly  1083 EVHQTEVA--------PEMK-------------PDIEELFTFEDDHDRASTQDSKSIDSFDMRPS 1126
            |..:..|:        .|::             ||.....:|   ||:|...|::     |.:..
Mouse  1028 EESELPVSGPGSCAFGEEIQMDGQPAASSGLGLPDYRSGVSF---HDQADLPDTE-----DFQAG 1084

  Fly  1127 TSAASAEEARESDGSPDKLVINELIYGARISPDKLSLKESQTPPALVPPPIGPRSPTIEIPMGPT 1191
            ...|.:.:.:|::.               :|..:||.|.|                |.|...|..
Mouse  1085 LYVAESPQPQEAEA---------------VSLGQLSDKSS----------------TSEASQGEE 1118

  Fly  1192 AGGIRRSFQLSAIDCDIGSRKSVDSFDLISQAVEQLPPPAEESEAEA------------------ 1238
            .||     .......|..|.||.||    ||.::|.....||.|.|.
Mouse  1119 RGG-----DDGGAPADKNSVKSGDS----SQDLKQSEGSEEEEEEEGCVVLEEDQEDEVTGTSEL 1174

  Fly  1239 --SDSL-----------------QASVISRLSEAKAVQNNRISEMSAESLVWLSHRLGPVLTSRF 1284
              ||::                 :...::..:|.|  :...:.:.:.:.:.|||.:|||.:.||.
Mouse  1175 TLSDTMLSMETVVAPGDGRDREEEEEPLTEQTEGK--EQKILLDTACKMVRWLSAKLGPTVASRH 1237

  Fly  1285 ITRNLLKLLSLCYVGQENLLPEVDDGGSSFN-SSPDAANLNYFSIANAR-VVGDRSAARVLECLM 1347
            :.||||:||:.||||...         ..|. ||.|...||..:|...| |:||..:..||.||:
Mouse  1238 VARNLLRLLTSCYVGPTR---------QQFTVSSDDTPPLNAGNIYQKRPVLGDIVSGPVLSCLL 1293

  Fly  1348 SIAALYGENFLLLQYFPHISELISLCS----KRITGSLEGAIISSLQLLKYMVPCLTDASIMEHL 1408
            .||.||||..|..||.|:||.|::..|    .|:....|..:::::.|.:.::..|:|.::|:.|
Mouse  1294 HIAYLYGEPVLTYQYLPYISYLVAPGSNSNPSRLNSRKEAGLLAAVTLTQKIIVYLSDTTLMDIL 1358

  Fly  1409 QHIMLDAILLPILRLLSSTNLVMPSGYLGRSLLARKFLDAIYALSVRLGSDMTREHLCQPLLNPF 1473
            ..|..: :|||:|..|:|.....|||...|::|..|.:..|..:.:|:|.:|.::||.:|:.. |
Mouse  1359 PRISHE-VLLPVLGFLTSFVTGFPSGAQARTVLCVKTISLIALICLRIGQEMVQQHLSEPVAT-F 1421

  Fly  1474 FLIFNKAFGL-PNDFACD--------LANLSLVGGASQP--ERALEELRDVFGPELAHTAYLTFL 1527
            |.:|:....| ..|...|        |...:...|..:|  ...||||:.||..|:|:|.|:.|.
Mouse  1422 FQVFSHLHELRQQDLPLDPKGCTEGQLPEATFSDGQRRPVDPTLLEELQKVFTLEMAYTIYVPFS 1486

  Fly  1528 RFLGEAN----------MKRTLSNLDFVLTLCH---EHEQPNGQSKIQL-ATNVSSGQDVDSVDA 1578
            ..||.|:          :::.:.|.:.|..|..   |...|:.::...: .|..|:|.:.|....
Mouse  1487 CLLGIAHHVPLHRVGDIIRKIIPNHELVGELAGLYLESMSPSSRNPASMEPTMASAGPEWDPQSG 1551

  Fly  1579 SC---ELAANSFGTQIVGNRLQVA------------------------RNNVELIDMVAYKLDQM 1616
            ||   :..:.:||:.:||||:|:.                        ||....:..      ::
Mouse  1552 SCLQDDGHSGTFGSVLVGNRIQIPDSQPQSPGPLGSLSGVGSSGGLSNRNEDNALKR------EL 1610

  Fly  1617 PKTRH-LKGNWLAYWRNETTRNEKDTQTLNLKQIRLQSFVGHTNSVRAIYALDNENSFISASKDK 1680
            |::.| |.|||||||:.|...:::|.. .:..|||||||.|||.:|:.:.||.:|:.|:|.|||:
Mouse  1611 PRSAHGLSGNWLAYWQYEIGVSQQDAH-FHFHQIRLQSFPGHTGAVKCVAALSSEDFFLSGSKDR 1674

  Fly  1681 TVKLWSLRSEGDGRKTSACQFTYTAHKKSINSLGFLESLRYVVSCDSGIHLWDPFIGRPLSVLDA 1745
            ||:||.|.:.|||...:|.:..|..|:||:..:|.||:.:||||||..:|:||||.|:.|..:|
Mouse  1675 TVRLWPLYNYGDGTNETASRLIYAQHRKSVFYVGQLEAPQYVVSCDGAVHVWDPFTGKTLRTVD- 1738

  Fly  1746 PRHSAV--TVVKCLPSHSPLVIAGTAESTVKMVDARSCEYVNEWRVCNASLPNATVRCLAVAPSG 1808
            |..|.|  |.|..:|:....:...:::||::.||.|.....:|:|: ...|....||.|||:|||
Mouse  1739 PSDSRVPLTAVAVMPAPHTSITMASSDSTLRFVDCRKPGLQHEFRL-GGGLNPGLVRSLAVSPSG 1802

  Fly  1809 NWLAAGLSSGCIVQLDTRTGMVINSWRPMECDLLQLAAPSDQFLVSSALDHSLAVWHALDGIMHY 1873
            ..:.||.|||.:|.||||||:|:..|...|.|:||:.|.....|:||:.||||.||..|:....:
Mouse  1803 RSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIKAVEGSVLISSSSDHSLTVWKELEQKPTH 1867

  Fly  1874 QLKPPPEPAHFLQSVGPSLVYATTGNRVGVYADVAHSHAFSTITKLRSETFRGVLTSLAVLPLNR 1938
            ..|...:|.|.....|..:|..|..|::|| ..:....:.:| |||.||.|||.|||||:||..|
Mouse  1868 HYKSASDPIHTFDLYGSEVVTGTVANKIGV-CSLLEPPSQAT-TKLSSENFRGTLTSLALLPTKR 1930

  Fly  1939 AFLAGNESGNIALL 1952
            ..|.|:::|.|.||
Mouse  1931 HLLLGSDNGIIRLL 1944

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117	134/242 (55%)
		WD40	1651..1876	CDD:475233	97/226 (43%)
		WD40 repeat	1662..1705	CDD:293791	18/42 (43%)
		WD40 repeat	1710..1744	CDD:293791	16/33 (48%)
		WD40 repeat	1752..1788	CDD:293791	9/35 (26%)
		WD40 repeat	1799..1836	CDD:293791	22/36 (61%)
Wdr81	XP_006532609.1	Beach	349..589	CDD:100117	122/239 (51%)
		WD40	<1644..1943	CDD:441893	121/301 (40%)
		WD40 repeat	1656..1699	CDD:293791	18/42 (43%)
		WD40 repeat	1704..1738	CDD:293791	16/33 (48%)
		WD40 repeat	1747..1783	CDD:293791	19/37 (51%)
		WD40 repeat	1793..1826	CDD:293791	8/32 (25%)
		WD40 repeat	1835..1868	CDD:293791	16/32 (50%)
		WD40 repeat	1875..1897	CDD:293791	10/21 (48%)