DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr81 and AgaP_AGAP002019

DIOPT Version :9

Sequence 1:	NP_609535.1	Gene:	Wdr81 / 34616	FlyBaseID:	FBgn0032395	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	XP_321036.4	Gene:	AgaP_AGAP002019 / 1281099	VectorBaseID:	AGAP002019	Length:	347	Species:	Anopheles gambiae

Alignment Length:	250	Identity:	60/250 - (24%)
Similarity:	102/250 - (40%)	Gaps:	51/250 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1640 DTQTLNLKQIR----LQSFVGHTNSVRAIYALDNENSFISASKDKTVKLWSLRSEGDGRKTSACQ 1700
            |.:||.:.::.    |::..||||.|.........|..:|.|.|::|::|.:|       |..|.
Mosquito   120 DDKTLKIWELSSGKCLKTLKGHTNYVFCCNFNPQSNLIVSGSFDESVRIWDVR-------TGKCL 177

  Fly  1701 FTYTAHKKSINSLGFLESLRYVVSC--DSGIHLWDPFIGRPLSVLDAPRHSAVTVVKCLPSHSPL 1763
            .|..||...::::.|......:||.  |....:||...|:.|..|....:..|:.||..| :...
Mosquito   178 KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP-NGKY 241

  Fly  1764 VIAGTAESTVKMVDARSCEYVNEW------RVCNASLPNATVRCLAVAPSGNWLAAG-------- 1814
            ::|.|.::|:|:.|....:.:..:      :.|  ...|.:|      ..|.|:.:|
Mosquito   242 ILAATLDNTLKLWDYSKGKCLKTYTGHRNEKYC--IFANFSV------TGGKWIVSGSEDHMVYI 298

  Fly  1815 --LSSGCIVQ-LDTRTGMVINSWRPMECDLLQLAAPSDQFLVSSAL--DHSLAVW 1864
              |.|..||| |...|..|          |.....|::..:.|:||  |.::.:|
Mosquito   299 WNLQSKEIVQTLQGHTDTV----------LCTACHPTENIIASAALENDKTIKLW 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117
		WD40	<1644..1877	CDD:225201	57/245 (23%)
		WD40	1651..1876	CDD:295369	56/234 (24%)
		WD40 repeat	1662..1705	CDD:293791	10/42 (24%)
		WD40 repeat	1710..1744	CDD:293791	8/35 (23%)
		WD40 repeat	1752..1788	CDD:293791	8/41 (20%)
		WD40 repeat	1799..1836	CDD:293791	12/47 (26%)
AgaP_AGAP002019	XP_321036.4	WD40	<47..347	CDD:225201	59/249 (24%)
		WD40	50..344	CDD:238121	59/249 (24%)
		WD40 repeat	61..98	CDD:293791
		WD40 repeat	104..140	CDD:293791	4/19 (21%)
		WD40 repeat	145..181	CDD:293791	11/42 (26%)
		WD40 repeat	188..223	CDD:293791	8/34 (24%)
		WD40 repeat	230..266	CDD:293791	9/36 (25%)
		WD40 repeat	274..311	CDD:293791	11/44 (25%)
		WD40 repeat	317..343	CDD:293791	7/35 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910