DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr81 and AgaP_AGAP004144

DIOPT Version :9

Sequence 1:	NP_609535.1	Gene:	Wdr81 / 34616	FlyBaseID:	FBgn0032395	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	XP_313026.4	Gene:	AgaP_AGAP004144 / 1273970	VectorBaseID:	AGAP004144	Length:	3686	Species:	Anopheles gambiae

Alignment Length:	1315	Identity:	265/1315 - (20%)
Similarity:	423/1315 - (32%)	Gaps:	486/1315 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 EAGGDGRFQVICD----KAWLQSLERNRRLTHFPSWPLLDRRSYPI--------------GQLEH 66
            |:||: ....|||    |.::||:            .||:::..|:              |.|.|
Mosquito  2609 ESGGN-HLSAICDVKMLKVFVQSI------------LLLNQKHIPLEDLRLVNAFYQSIDGGLSH 2660

  Fly    67 PWTRILVQTYR-----------KQPQSRVYPLPRISGDAPSSELPLSYS---QAVSFVAHSNFKQ 117
            ..:..|.||.:           .|.|:.:..:.|        :..|.||   .|:....:|..||
Mosquito  2661 GASWNLTQTLKDFEYLRAISMNDQEQTIMKSIAR--------QEKLIYSCTVAAMQITRNSVEKQ 2717

  Fly   118 --LWEEA---------YRKYNGAHVRMCRSTPSAPSTKPPSGQGQLQPH----------DVVLKE 161
              |.:|.         ||.|:..|..:.|.|    ....|....:|.|:          |:.||
Mosquito  2718 NRLRKELIIQLRKDNDYRFYDQWHRLVDRMT----HDDAPWYNARLYPNSWELDDTYGPDMALK- 2777

  Fly   162 LIQRVYRCPVLHCQLDR------------DGVSDSSNATSCSA----------GSCHANVLPALV 204
               |:.|||:   .:||            .|..:....|...|          .|....||....
Mosquito  2778 ---RMRRCPM---TIDRRFLLKETVPESKHGAEEEREQTPLLAYLFSNDYRHEYSVEEQVLYTFT 2836

  Fly   205 AIETSTHISVFFYPPAL--ECSLYDCITFSPALLGKNYNKTLFVIYQILQLAKHLQGQGLFLGDL 267
            ..:||         |:.  ||   :||..|..|:.|.|:                      .|:|
Mosquito  2837 VRKTS---------PSYEQEC---ECIITSTELVLKPYD----------------------AGEL 2867

  Fly   268 RLQDIVLRENLWLQ--------VLPRLQCNLLDDDPAGEDMSPLTPLVSEDLGEAREAQQALPSS 324
            .:.|:.....:|.:        |...|:|.           ..|..:...|           ||.
Mosquito  2868 EIYDLHDITKIWTKRYEHQESAVEVFLKCG-----------KSLFIVFHRD-----------PSE 2910

  Fly   325 STMFDLRFAYD----PAHFNLREYTEMWCNGQLSNFDYLTILNNACGRSLTNAAYHHIMPWV-TD 384
            ...|: .|.:|    .....|..||:.|..|.|||::||.:||...||:..:...:.:.||| .:
Mosquito  2911 RDTFE-GFFHDLVVRCGRQELDHYTQQWREGALSNWEYLMLLNQIAGRTYHDLMQYPVFPWVLAN 2974

  Fly   385 FSGR-----GGGAWRDLTK---------SKYRLNKGDVHLDLMYAHASQHGSAD--GSYQAIGDQ 433
            :..|     ...::|.|.|         .|:.:|.        |.|..|..|.|  |..:.|  |
Mosquito  2975 YDTRTLDLLAERSFRVLEKPIAVQHRELEKHYINN--------YNHLRQAESGDPNGGRRKI--Q 3029

  Fly   434 APHHVSDFLSEITYFVYMARRTPQSILCAH---------------VRPIW--VPAEYPVSIQRLQ 481
            ..|:.|.:.:..|...::.|..|.:.|...               ::..|  ...:.|..::
Mosquito  3030 PYHYSSHYSNSGTVLHFLVRVLPFTSLFLQYQDDSFDIPDRTFHSLQTTWNLASKDSPTDVK--- 3091

  Fly   482 EWTPDECIPEFYSDPMIFKSIH----------EDLPDLELPAWATCPED---FICKHREALESQY 533
                 |.||||::.|...::..          |.:..:|||||  |...   |:..||:|||:..
Mosquito  3092 -----ELIPEFFTFPEFLENQEGFDFGTRQSGEPVNHVELPAW--CGGSARLFVLIHRQALEANI 3149

  Fly   534 VSERLHHWIDLNFGYKLSGKAAVKSKNV------C----------------LTLVDQHRNLSQRG 576
            |..:|.|||||.||||.||:||:.:.||      |                .|:|..:..:.:|
Mosquito  3150 VRRQLSHWIDLIFGYKQSGQAAIDAINVFHPATYCDFTASDIDDPVMKLALETMVKTYGQMPRR- 3213

  Fly   577 IVQLFASAHPPRRYATPWFSRTAPRLSQLYASPAKRLAKSTENLQAESATGSSHLS-LRLGDDGS 640
               ||.:.|||            |.::.|.|:|.|.| :|...|:.....||..|| .||.|...
Mosquito  3214 ---LFDTPHPP------------PAMNPLVANPPKVL-ESVIGLRWGLYCGSPILSDPRLADVWE 3262

  Fly   641 SGSVHS---------SSASASASNFYAITNFIELPENYNPALLLHNLETLEAFYARTFPQQRASA 696
            ..|..|         :...|:.:.......|: ||:..|            .|.|.|    :.:.
Mosquito  3263 KHSKESLGGIVIERGTLPPAALATLDGDKVFV-LPDKMN------------IFCATT----QGTG 3310

  Fly   697 NPEEKMISSDLMFE-------QNSAEHSFTNQLFASGDELPPKSKNLLREKRNCLQHLLNVRKER 754
            :.:...||...|.:       |::.......:||...:.:............:|......
Mosquito  3311 SKKHYTISWGEMDDRLRIRLLQDTGSTERPRELFYGSNSVAYDPITACGSDAHCTSIFFG----- 3370

  Fly   755 DLHVLGCLII---------ELFAMQRLRP--LLMGNGLTATFDSRLSACRTVAQLHRQELPKPVR 808
              |..|.:::         ..|..|.::|  .:|....:::|  |....|..|.|.|
Mosquito  3371 --HRSGRIVVFQQRSRRRRGSFFNQNMQPSVAMMSRSRSSSF--RRWIDRKSANLRR-------- 3423

  Fly   809 RVVRLLLQLEQPGEEDQGLPQ-----PPN-------PAQLLEPMFSNLLLPFPSHYMAVYALVRS 861
                   :||...:|.|..||     ||:       |.|||:
Mosquito  3424 -------RLEMDPDEQQPQPQQEQRLPPDDQIDWAYPIQLLK----------------------- 3458

  Fly   862 LHAFEANAVLLELQTHFSCKGGRECERYTEMDRQRVLFERKIAECKVMSCCA---------HVKR 917
             |....:|:                         |:..|.|||....:..||         :|:.
Mosquito  3459 -HRAPISAI-------------------------RISMEYKIAVSVSLDGCAAIWDVNSLMYVRE 3497

  Fly   918 LLEPMSFAYEQFTPVELLLPHIIDLLRDERTSILTAWNLFDPIAQALGVSQTQQHLLQPLLKLYD 982
            :.:|::..:.:.:.|                          .|:..||                |
Mosquito  3498 IPKPVNMLHSRISHV--------------------------AISPTLG----------------D 3520

  Fly   983 VESVSSPDDGGSNGST-NSGGHLRFSASS------SFKSRKSVKLYHHSFLLRLIVRFGLRCFL- 1039
            :..|.|...|.:..:| .:||...:|:::      ||:..::....:.:..:....|..||.:.
Mosquito  3521 IVLVHSASAGSARPATATTGGQESWSSATLVEEDDSFEVTENYNADYVNITMDTNRRDQLRLYTI 3585

  Fly  1040 ------HHFIAPLIEAVGGYKEPEQGNGYH-----YHSGGSR-RTSKNLNFASENEVHQTEVAPE 1092
                  |.|:...|:|: .|...::|.|.:     ..||..| .:|.||....|..|....|...
Mosquito  3586 NAQYVEHVFVESPIQAI-TYSTVKEGCGVNCIVVALESGIVRFYSSWNLALLREVNVEPNGVKCA 3649

  Fly  1093 MKPDIEELFTFEDDH 1107
            :....:.|....|.:
Mosquito  3650 LFSKYQHLILLTDSN 3664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117	81/311 (26%)
		WD40	<1644..1877	CDD:225201
		WD40	1651..1876	CDD:295369
		WD40 repeat	1662..1705	CDD:293791
		WD40 repeat	1710..1744	CDD:293791
		WD40 repeat	1752..1788	CDD:293791
		WD40 repeat	1799..1836	CDD:293791
AgaP_AGAP004144	XP_313026.4	PH-like	2829..2914	CDD:302622	24/140 (17%)
		Beach	2935..3221	CDD:280327	79/309 (26%)
		WD40	<3459..>3533	CDD:295369	19/140 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1786
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820