DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr81 and AgaP_AGAP000017

DIOPT Version :9

Sequence 1:	NP_609535.1	Gene:	Wdr81 / 34616	FlyBaseID:	FBgn0032395	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	XP_311142.5	Gene:	AgaP_AGAP000017 / 1272258	VectorBaseID:	AGAP000017	Length:	3676	Species:	Anopheles gambiae

Alignment Length:	510	Identity:	121/510 - (23%)
Similarity:	194/510 - (38%)	Gaps:	134/510 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 QILQLAKHLQGQGLFLGDLR--------LQDIVL------RENLW------------LQVLPRLQ 287
            ::|:...||.|:..| .::|        ||::.|      |.::.            ::.|||:.
Mosquito  2924 EVLKYCDHLHGKWYF-SEIRAIFSRRYLLQNVALEIFLASRTSILFAFPDQHTVKKVIKALPRVG 2987

  Fly   288 CNLLDDDPAGEDMSPLTPLVSEDLGEAREAQQALPSSSTMFDLRFAYDPAHFNLREYTEMWCNGQ 352
            ..:....|.....|.::|             :.|..:|.|                 |:.|...:
Mosquito  2988 VGIKYGIPQTRRASMMSP-------------RQLMRNSNM-----------------TQKWQRRE 3022

  Fly   353 LSNFDYLTILNNACGRSLTNAAYHHIMPWV-TDFSGR-----GGGAWRDLTKSKYRLNKGDVHLD 411
            :|||:||..||...||:..:...:.:.||| |::..|     ....:|||:|....||
Mosquito  3023 ISNFEYLMFLNTIAGRTYNDLNQYPVFPWVITNYESRELDLSQPSNYRDLSKPIGALN------- 3080

  Fly   412 LMYAHASQHGSADGSYQAIGDQA--PHHVSDFLSEITYFV-YMARRTPQSILCAHVR------PI 467
                 .|:....:..|:......  |.|.....|...:.: ::.|..|.:.:...::      |.
Mosquito  3081 -----PSRREYFEERYETWDTPGIPPFHYGTHYSTAAFVLNWLIRIEPFTTMFLALQGGKFDHPD 3140

  Fly   468 WVPAEYPVSIQRLQEWTPD--ECIPEFYSDPMIFKSIHE----------DLPDLELPAWATCPED 520
            .:.:...:|.:..|..|.|  |.|||:|..|.:|.:..:          .:.|:|||.||..||:
Mosquito  3141 RLFSSVALSWKNCQRDTSDVKELIPEWYFLPEMFYNASDYRLGQRDDGSTVGDVELPPWAKTPEE 3205

  Fly   521 FICKHREALESQYVSERLHHWIDLNFGYKLSGKAAVKSKNVCLTLV------------------- 566
            |:..:|.||||::||.:||.||||.||||..|..|:::.||...|.
Mosquito  3206 FVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAMRATNVFYYLTYEGSVDLDTIGDPVTRDAI 3270

  Fly   567 -DQHRNLSQRGIVQLFASAHPPRRYA---TPWFSRTAP-----RLSQLYASPAKRLAKST-ENLQ 621
             :|.||..|...: |....||||..|   :|....|.|     .|.....||...::.:| ..|.
Mosquito  3271 ENQIRNFGQTPSL-LLMEPHPPRSSAMHLSPMMFNTMPDDVCMSLKFHLNSPIIHISANTYPQLP 3334

  Fly   622 AES---ATGSSHLSLRLGDDGSSGSVHSSSASASASNFYAITNFIELPENYNPAL 673
            ..|   .|.....::...:...:.|:.|.|.:.|..|..|     .||...:|.|
Mosquito  3335 LPSVVTVTAGHQFAVNRWNCQYTASIQSPSYAESTQNLNA-----NLPLTMDPLL 3384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117	79/289 (27%)
		WD40	<1644..1877	CDD:225201
		WD40	1651..1876	CDD:295369
		WD40 repeat	1662..1705	CDD:293791
		WD40 repeat	1710..1744	CDD:293791
		WD40 repeat	1752..1788	CDD:293791
		WD40 repeat	1799..1836	CDD:293791
AgaP_AGAP000017	XP_311142.5	LamG	235..383	CDD:304605
		DUF4704	635..919	CDD:292415
		DUF1088	2659..2864	CDD:284000
		PH_BEACH	2887..2984	CDD:291510	10/60 (17%)
		Beach	3016..3292	CDD:280327	78/288 (27%)
		WD40	<3413..3664	CDD:225201
		WD40	<3414..3620	CDD:295369
		WD40 repeat	3457..3508	CDD:293791
		WD40 repeat	3513..3548	CDD:293791
		WD40 repeat	3555..3589	CDD:293791
		WD40 repeat	3595..3630	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910