DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr81 and wdr81

DIOPT Version :9

Sequence 1:	NP_609535.1	Gene:	Wdr81 / 34616	FlyBaseID:	FBgn0032395	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	XP_002664681.1	Gene:	wdr81 / 100333062	ZFINID:	ZDB-GENE-030131-3389	Length:	2065	Species:	Danio rerio

Alignment Length:	2321	Identity:	676/2321 - (29%)
Similarity:	1016/2321 - (43%)	Gaps:	645/2321 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EIGVDPQHVCEAGGDGRFQVICDKAWLQSLERNRRLTHFPSW---------PLLDRRSYPIGQLE 65
            ::|:|.:....:.......|:....|:.:| ||:|:|....:         .||.|     .|::
Zfish    11 DLGIDQRQTAHSQRPNELVVLVPTRWVMAL-RNKRVTRCAKYESFSEGEICTLLQR-----SQMK 69

  Fly    66 HP--WTRILVQTYRKQPQSRVYPLPR---ISGDAPSSELPLSYSQAVSFVAHSNFKQLWEEAYRK 125
            .|  |||:.:|..||:...  |...|   ..|:..|.:..::..|.||   .|||:.||.|||.
Zfish    70 LPSGWTRVCIQGLRKRKLG--YRFARETGCHGEGLSQDSFMTLMQGVS---QSNFRNLWHEAYM- 128

  Fly   126 YNGAHVRMCRSTPSAPSTKPPSGQGQLQPHDVVLKELIQRVYRCPVLHCQ--LDRDGVSDSSN-- 186
               .||:     |.|.|.:    |..:...|.| ::.:|:::      |.  :..|.||.|.:
Zfish   129 ---THVQ-----PYADSVE----QTPVLALDAV-RQALQKLF------CSNFISTDRVSPSLSPA 174

  Fly   187 ---------ATSCSA-----GSCHANVLPALVAIETSTHISVFFYPPALECSLYDCITFSPALLG 237
                     .::|||     .|...|||||...:|:...:.|.|  |..:.:::|.:|:|||.|.
Zfish   175 KEKEKDCPFLSTCSAPKQSTESLCPNVLPAECLLESEEVLYVVF--PYTQYTVHDIVTYSPAKLA 237

  Fly   238 KNYNKTLFVIYQILQLAKHLQGQGLFLGDLRLQDIVLRENLWLQVLPRLQCNLLDDDPAGEDMSP 302
            .:..|.||::||:|...:.....||..|:|.|.||.:.|    |:..||:.:|..
Zfish   238 NSNAKILFILYQLLIAMRECHASGLLCGELSLLDIAVDE----QLCSRLKISLAH---------- 288

  Fly   303 LTPLVSEDLGEAREA-----QQALPSSSTMFD----------LRFAYDPAHFNLREYTEMWCNGQ 352
                 .|...|.|:|     |..:|.|.:..|          .|...|    .|:.....|.|||
Zfish   289 -----YEKFKEYRDAVPYALQNKVPMSVSTKDNHNNGVSGQLCRNCQD----ELKSLVLDWVNGQ 344

  Fly   353 LSNFDYLTILNNACGRSLTNAAYHHIMPWVTDFS---GRGGGAWRDLTKSKYRLNKGDVHLDLMY 414
            :|||.||..||...||...:..||.::|||.||:   ||    :|||.|||:||||||..||..|
Zfish   345 VSNFQYLMELNRLAGRREGDPNYHPVLPWVVDFTVPYGR----FRDLKKSKFRLNKGDKQLDFTY 405

  Fly   415 -----AHASQHGSADGSY--------------QAIGDQAPHHVSDFLSEITYFVYMARRTPQSIL 460
                 |.|:..||...:|              |:.....|||:||.||:|||:||.||:||:|:|
Zfish   406 EMTKEALAAVSGSGGSNYPPDLGGPVVPGGPGQSDHLHVPHHISDVLSDITYYVYKARQTPKSVL 470

  Fly   461 CAHVRPIWVPAEYPVSIQRLQEWTPDECIPEFYSDPMIFKSIHEDLPDLELPAWATCPEDFICKH 525
            |:|||..|.|.|||.|::|:|.|||||||||||.||.||:|||.|:|||::|.|....|:||..|
Zfish   471 CSHVRSQWEPNEYPASMERIQSWTPDECIPEFYRDPSIFRSIHPDMPDLDVPPWCNSYEEFIAVH 535

  Fly   526 REALESQYVSERLHHWIDLNFGYKLSGKAAVKSKNVCLTLVDQHRNLSQRGIVQLFASAHPPR-- 588
            |:.|||:.||::|||||||.||||||||.|:|:|||||.|||.|.:|:..|:||||...||||
Zfish   536 RQLLESREVSQQLHHWIDLTFGYKLSGKEAIKAKNVCLHLVDNHTHLTSYGVVQLFDHPHPPRLA 600

  Fly   589 --RYA---TPWFSRTAPRLSQLYASPAKRLAKSTENLQAESATG--SSHLSLRLGDDGS------ 640
              :||   .|.|.|......|:  .|.:......:.|..| |||  ||..|: :|.|..
Zfish   601 LYQYAPPEPPHFGRVNVTTWQI--PPLETTMDGVDGLVPE-ATGCESSGWSV-VGRDEELEQAIE 661

  Fly   641 ----SGSVHSSSASAS------------------------------------------------- 652
                |||..|:|||.|
Zfish   662 ALDLSGSSSSTSASVSIPVVGSAAGKTSGETIGLVVSPSHGSFPGEATGNVTNTLGSGIRTAMLH 726

  Fly   653 ----------ASNFYAITNF-IELPENYNPALLLHNLETLEAFYARTFPQQRASANPEEKMISSD 706
                      |||   :.:| |.||:.:.|...|..||.|..|..              |.:.|:
Zfish   727 RAASVSKKPEASN---LEDFKISLPDGFKPLQPLEELEKLNTFLV--------------KGLHSE 774

  Fly   707 LMFEQNSAEHSFTNQLFASGDELPPKSKNLLREKRNCLQHLLNVRKERDLHVLGCLIIELFAMQR 771
            :   :::.:.....:...|..::|....:|.               :||:..||.||.|:|...:
Zfish   775 I---EHTMDLGINKKDLRSVPKVPLSFTDLF---------------QRDMQALGVLIAEIFYSSK 821

  Fly   772 LRPLLMGNGLTATFDSRLSACRTVAQLHRQELPKPVRRVVRLLLQLEQ-----------PGEEDQ 825
            ||.|.....|...|.:.|..|.|    :.:::|.|:...:..|||:.:           |    |
Zfish   822 LRGLRPETHLRDRFQAVLKLCST----NLRDVPLPLHHALDTLLQVHKHCLKTETIIMHP----Q 878

  Fly   826 GLP------------QPPNPAQLLEPMFSNLLLPFPSHYMAVYALVRSLHAFEANAVLLELQTHF 878
            |||            .||||.|||.|:.|.  ||||.::..::..:.|.|:
Zfish   879 GLPFLFKYDPICEGLPPPNPWQLLSPIVSP--LPFPEYFPTLHKFIFSYHS-------------- 927

  Fly   879 SCKGGRECERYTEMDRQRVLFERKIAECKVMSCCAHVKRLLEPMSFAYEQFTPVELLLPHIIDLL 943
                  :.|....:..:.::|              ::.:.||.:.........:|:|||.::.|:
Zfish   928 ------KMESINNIQGRDIVF--------------NLWQQLETLLKGDITTEGLEILLPFVLSLM 972

  Fly   944 RDERTSILTAWNLFDPIAQALGVSQTQQHLLQPLLKLYDVESVSSPDDGGSNGSTNSGGHLRFSA 1008
            .:|.|::..||.||:|:::.||.....::|::||:.:|:            |.....|   ||
Zfish   973 SEESTAVYAAWYLFEPVSRVLGPRNASKYLIKPLVGVYE------------NPRCLRG---RF-- 1020

  Fly  1009 SSSFKSRKSVKLYHHSFLLRLIVRFGLRCFLHHFIAPLIEAVGGY-------------------- 1053
                      .||...|:|:||||.||:.||...:..:::.:.|:
Zfish  1021 ----------YLYTDCFVLQLIVRLGLQVFLSSLLPHVLQVMTGFESCNTAAGTEWEGMKVLRGA 1075

  Fly  1054 -----KEPEQ-----------------GNGYHYHSGG----------SRRTSKNLN---FASENE 1083
                 :|.|:                 |.|....|||          ...:..:||   |.:|.|
Zfish  1076 AGALDEEEEEYECDDRRSSNATSSGKVGGGSGGGSGGVGVVGDQGLVDYSSGISLNDQVFLNEGE 1140

  Fly  1084 VHQTEVAPEMKPDIEELFTFEDDHDRASTQDSKSIDSFDMRPSTSAASAEEARESDGSPDKLVIN 1148
                        |.:..|...:....|:|..:|       :.:.|.|:.::.:||
Zfish  1141 ------------DFQNGFYVNNSASGATTVGTK-------QQNQSTANKDQDQES---------- 1176

  Fly  1149 ELIYGARISPDKLSLKESQTPPALVPPPIGPRSPTIEIPMGPTAGGIRRSFQLSAIDCDIGSRKS 1213
                   :|..|||.|.|.:                |:.:|                 |..|.||
Zfish  1177 -------LSVGKLSDKSSAS----------------EVSIG-----------------DRASLKS 1201

  Fly  1214 VDSFDLISQA----------------------VEQLPP-------PAEESEAEASDSLQASVISR 1249
            .||...:.||                      |:::|.       ..|||||..: :|:..|::.
Zfish  1202 ADSSQDLKQASDGEDGGELEDEEETVEDREITVQRVPSLEMTLSVCTEESEATVA-TLEGDVMNG 1265

  Fly  1250 LSEAKAVQNNRISEMSAESLV-------------------WLSHRLGPVLTSRFITRNLLKLLSL 1295
            :.:....:|....|...:.|.                   |||.:|||.||||||.||||:||:.
Zfish  1266 IVQEDGEKNMEEEETEHDPLEDSEEKEHKILLDTVCKTVRWLSAKLGPTLTSRFIARNLLRLLTS 1330

  Fly  1296 CYVG-----------QENLLPEVDDGGSSFNSSPDAANLNYFSIANARVVGDRSAARVLECLMSI 1349
            ||:|           :||.|..|   ||.:...|              ||||::|..|||||:.|
Zfish  1331 CYIGLDKHQFMLSVNEENSLECV---GSVYEKKP--------------VVGDQTARPVLECLIYI 1378

  Fly  1350 AALYGENFLLLQYFPHISELISLCSK-RITGSLEGAIISSLQLLKYMVPCLTDASIMEHLQHIML 1413
            |.||||..|..||.|:|..|:|..|. |:....|..::.::.|.:.::..|:|.::|:.|..|..
Zfish  1379 AHLYGEPVLTYQYLPYIGYLVSPPSSCRLNTRKEAGLLGAVVLTQKIIVFLSDTTLMDMLMKINQ 1443

  Fly  1414 DAILLPILRLLSSTNLVMPSGYLGRSLLARKFLDAIYALSVRLGSDMTREHLCQPLLNPFFLIFN 1478
            : :|||:|.||:||.:..|||...||.:..|.|..:..:.:|:|.:|.::|:.: .|:.||.:|:
Zfish  1444 E-VLLPLLDLLTSTKMGFPSGVQTRSAVCLKTLSLMALICLRIGREMVQQHMAE-TLSRFFQVFS 1506

  Fly  1479 KAFGLPNDFA---------CDLANLSLVGGASQPER--ALEELRDVFGPELAHTAYLTFLRFLGE 1532
            ....|.|...         |...:|.:..||.....  .||||:.||.||:|:.:|:.|...:|:
Zfish  1507 LLQFLQNQIGSAPRREVAECTYLDLRIPDGAELTIELGVLEELQAVFNPEMAYASYIPFYCLIGD 1571

  Fly  1533 ANMKRTLSNLDFVLTLC---HEHEQPNGQSKIQLATNVSSGQDVDSVDASCELA----------- 1583
            :.:::.::|.:.|.:|.   ||...|....     :|...||...:|..|..:.
Zfish  1572 SGIRKLVTNHELVWSLAQSYHERASPGSPE-----SNPVGGQRASAVGLSPSMGRQMSRSPFPAP 1631

  Fly  1584 --------------ANSFGTQIVGNRLQVARN-------NVELIDM------------------- 1608
                          :.:||:.:||||:||.|:       |:..::.
Zfish  1632 SSTSTPLGGDILPESGTFGSHLVGNRIQVTRDTEACGSPNLSSLETWTHGRPYGSNAPPMSLATT 1696

  Fly  1609 ------------------------VAYKLDQMPKTRHLKGNWLAYWRNETTRNEKDTQTLNLKQI 1649
                                    .|.|.|....:|.|:|||||||:.|...|::|:. .:..||
Zfish  1697 ALSSAGPSFSHSSYSWVMGPTPEDSALKQDLPRSSRSLQGNWLAYWQYEIGLNQQDSH-FHFHQI 1760

  Fly  1650 RLQSFVGHTNSVRAIYALDNENSFISASKDKTVKLWSLRSEGDGRKTSACQFTYTAHKKSINSLG 1714
            |||||:||:.:.:.:..|..|:.|:|.||||||:||.|.:.|||.:....:.|||.|:|||..:|
Zfish  1761 RLQSFIGHSGTAKCLAPLAGEDYFLSGSKDKTVRLWPLYNHGDGTREVEPRLTYTEHRKSIFYVG 1825

  Fly  1715 FLESLRYVVSCDSGIHLWDPFIGRPL---SVLDAPRHSAVTVVKCLPSHSPLVIAGTAESTVKMV 1776
            .||:|:.|||||..:||||.|.|:.:   ..||.  .:.:|.|..:|:....|:..:|:|.::.:
Zfish  1826 QLEALQEVVSCDGTVHLWDQFTGKNIRCNEPLDG--KNPITAVTTMPAPHCSVVFASADSVLRFI 1888

  Fly  1777 DARSCEYVNEWRVCNASLPNATVRCLAVAPSGNWLAAGLSSGCIVQLDTRTGMVINSWRPMECDL 1841
            |.|.....:|:|:..::|....:|||||:|.|..:|||.|:|.||.||.|||:|:..|...|.|:
Zfish  1889 DPRKPGLQHEFRLAYSNLSAGLIRCLAVSPGGRTIAAGFSTGFIVLLDARTGLVLRGWPGHEGDI 1953

  Fly  1842 LQLAAPSDQFLVSSALDHSLAVWHALDGIMHYQLKPPPEPAHFLQSVGPSLVYATTGNRVGVYAD 1906
            ||:.|.....||||:.||:|.||..::....:|.:.|.:|.|.....|..:|..|..|::|||:.
Zfish  1954 LQMKAAEGNLLVSSSSDHTLTVWKDVEHKPLHQYRTPSDPIHAFDLYGAEIVAGTVANKIGVYSI 2018

  Fly  1907 VAHSHAFSTITKLRSETFRGVLTSLAVLPLNRAFLAGNESGNIALL 1952
            :..:.:.:..|||.:|.|||.||||:|||..|..|.|:::|.|.||
Zfish  2019 LDSTASLAGSTKLSTENFRGTLTSLSVLPTKRLLLLGSDNGAIRLL 2064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117	141/264 (53%)
		WD40	<1644..1877	CDD:225201	96/235 (41%)
		WD40	1651..1876	CDD:295369	93/227 (41%)
		WD40 repeat	1662..1705	CDD:293791	18/42 (43%)
		WD40 repeat	1710..1744	CDD:293791	16/36 (44%)
		WD40 repeat	1752..1788	CDD:293791	9/35 (26%)
		WD40 repeat	1799..1836	CDD:293791	21/36 (58%)
wdr81	XP_002664681.1	Beach	339..598	CDD:100117	141/262 (54%)
		WD40	1767..2063	CDD:330360	118/297 (40%)
		WD40 repeat	1822..1859	CDD:293791	16/36 (44%)
		WD40 repeat	1863..1900	CDD:293791	9/36 (25%)
		WD40 repeat	1912..1947	CDD:293791	20/34 (59%)
		WD40 repeat	1953..1988	CDD:293791	13/34 (38%)
		WD40 repeat	1996..2033	CDD:293791	10/36 (28%)
		WD40 repeat	2040..2063	CDD:293791	12/22 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587062
Domainoid	1	1.000	267	1.000	Domainoid score	I1831
eggNOG	1	0.900	-	-		E1_KOG1786
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13983
Inparanoid	1	1.050	802	1.000	Inparanoid score	I474
OMA	1	1.010	-	-		QHG48726
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	1	1.000	-	-		FOG0006096
OrthoInspector	1	1.000	-	-		oto40796
orthoMCL	1	0.900	-	-		OOG6_105710
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2948
SonicParanoid	1	1.000	-	-		X4393
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.740