DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr81 and cubn

DIOPT Version :9

Sequence 1:	NP_609535.1	Gene:	Wdr81 / 34616	FlyBaseID:	FBgn0032395	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	XP_012821080.2	Gene:	cubn / 100125884	XenbaseID:	XB-GENE-957007	Length:	3631	Species:	Xenopus tropicalis

Alignment Length:	1465	Identity:	261/1465 - (17%)
Similarity:	419/1465 - (28%)	Gaps:	551/1465 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 RISGDAPSSELPLSYSQAVSFVAHSNFKQLWEEAYRKYNGAHVRMC--RSTPSAPSTKPPSGQGQ 151
            ||..||.:.|....|:.:...::..|:..|:         .|.|:|  |.|       .|:|:..
Frog  2458 RIRYDASTEECGGDYTASSGIISSPNYPNLY---------PHNRVCEWRIT-------VPAGRRV 2506

  Fly   152 LQPHDVVLKELIQR-------VY-----RCPVLH--C-------QLDRDG-------VSD---SS 185
            ....:.:|.:..|.       ||     :.|:|.  |       ::...|       |:|   ||
Frog  2507 TLTINALLLQDQQNCDYDYVAVYNGYQNQSPLLRKLCGNVAPETEVKSSGNTMRVIFVTDGSVSS 2571

  Fly   186 NATSCSAGSCHANVLPALVAIETSTHIS------VFFYPPALECSLYDCITFSPALLGKNYNKTL 244
            .....:..|....|....:|..|..|.|      |..|...|.|   :.|..:|    ...|.|.
Frog  2572 GGFLATFNSMEDAVCGGALADPTGGHFSSPGYDQVNNYTRNLNC---EWIIQNP----NTENSTT 2629

  Fly   245 FVIYQILQLAKHLQGQGLFLGDLRLQD-------------------IVLRENLWLQVLPRLQ--- 287
            |:.::.|||..||..|..|: :||..:                   .::...:|:..:...:
Frog  2630 FISFKRLQLEYHLNCQRDFI-ELRFDNADGELITRLCGRNTPSVPLAIVASQVWVHFVSNAEVEN 2693

  Fly   288 -----------CNLLDDDPAGEDMSPLTPLVSEDLGEAREAQQALPSSSTMFDLRFAYDPAHFNL 341
                       |..:.....|...||..|.....:........|  ....:..|.|    .||::
Frog  2694 IGFNASYSFTDCGGIQAGEYGVIASPNFPASYNSMSHCAWLLDA--PEGHIITLSF----IHFDI 2752

  Fly   342 REYTEMWCNGQLSNFDYLTILNNACGRSLTNAAYHHIMPWVTDFSGRGGGAWRDLTKSKYRLNKG 406
            ..:       |:..:|.:||||.|...|          |.:..|.|         |.|...:..|
Frog  2753 ESH-------QICRWDSVTILNGASPGS----------PLIGQFCG---------TTSPGTIQSG 2791

  Fly   407 DVHLDLMYAHASQHGSADGSYQAIGDQAPHHVSDFLSEITYFVYMARRTPQSILC-AHVRPIWVP 470
            ...|.:::       ::|.|....|                  :.|..|..|:.| .||
Frog  2792 SNKLLVIF-------NSDDSLHGRG------------------FYANWTSDSLGCGGHV------ 2825

  Fly   471 AEYPVSIQRLQEWTPDECIPEFYSDPMIFKSIHEDLPDLELPAWATCPEDFICKHR--EALESQY 533
                                            |.|...:..|||   |:.|....|  ..:|:..
Frog  2826 --------------------------------HADSGTIRSPAW---PQHFPANSRCTWTIETHA 2855

  Fly   534 VSERLHHWIDLNFGYKLSGKAAVKSKNVCLTLVDQHRNLSQRGIVQLFASAHPPRRYATPWFSRT 598
            .|   |:.:..|..:.:...                             :.|..|.|...|....
Frog  2856 SS---HYELSFNNNFHIPDD-----------------------------NGHCQRSYVKVWSGAE 2888

  Fly   599 APRLSQLYASPAKRLAKSTENL-----QAESATGSSHLSLRLGDDGSSGSVHSSSASASASNFYA 658
            ...|:......|.....|..|:     |::.|.||...:..:...|::.:  :||....:.|:
Frog  2889 EELLATGCGDTAPAPVISPRNVIRVTFQSQDAPGSGFFASFISKCGANFT--NSSGRIMSPNY-- 2949

  Fly   659 ITNFIELPENYNPALLLHNLETLEAFYARTFPQQRASANPEEKMISSDLMFEQNSAEHSFTNQLF 723
                   |..|.     :||......:|            |..|..  ::|.||....|   .|.
Frog  2950 -------PNKYG-----NNLRCNYTIHA------------EANMFI--VLFFQNFEVES---SLS 2985

  Fly   724 ASGDELPPKSKNLLREKRNCLQHLLNVRKERDLHVLGCLIIELFA---------MQRLRPLLMGN 779
            .|.|.|    |....|:.:.|.:|........:...|.:.:..:.         |...|.:..|.
Frog  2986 CSKDGL----KIFGGERTSPLANLCGASVPASISARGSMSLNFYTDSDINMHGFMATYRVIPCGG 3046

  Fly   780 GLTATFDSRLSACRTVAQLHRQELPKPVRRVVRLLLQLEQPGEEDQGLPQPPNPAQLLEPMFSNL 844
            ...|::.:..|........|..     :.....:.:|                ..:::|..|:.|
Frog  3047 TFNASYGTLRSPTYAFTDYHNN-----MNCTYHVTVQ----------------ENKIIELKFNEL 3090

  Fly   845 LLPFPS----HYMAVYALVRS----------------LHAFEANAVLLEL-QTHFSCKGGRECER 888
            .|...|    .|:|||..:.|                |.:...|..||.: ..|.:.:|.|...|
Frog  3091 DLEASSSCLYDYIAVYDGLNSSSPLLGRYCGNVLPPILRSSSNNLFLLFVTDNHITSRGWRATFR 3155

  Fly   889 YTEMDRQRVLFERKIAECKVMSCCAHVKRLLEPMSFAYEQFT--------PVELLLPHIIDLLRD 945
            .|                            |.||.......|        |         |...|
Frog  3156 QT----------------------------LGPMQGCGGYLTNAAGTFGSP---------DSNLD 3183

  Fly   946 ER--TSILTAWNLFDPIAQALGV--------SQTQQHLLQPLLKLYDVESVSSPDDGGSNGSTNS 1000
            .|  :::..||::..||...:.:        :|::.......:|::         ||.:..|...
Frog  3184 GRYDSNLNCAWHIIAPINTQINLTFSAFFLEAQSRSTCRYDYVKVF---------DGSTTDSNLQ 3239

  Fly  1001 GGHLRFSASSSFKSRKSVKLYHHSFLLRLIVRFGLRCFLHHFIAPLIEAVGGYKEPEQGNGYHYH 1065
            |.:...|..:.|.|..:|          |.|.|                |.......||....|.
Frog  3240 GTYCGSSRPAPFLSTSNV----------LTVLF----------------VSDSSVERQGFNASYV 3278

  Fly  1066 S-----GGS-RRTSKNLNFASENEVHQTEVAPEMKPDIEELFTFED----DHDRASTQDSKSIDS 1120
            :     ||| ..||.::..:|.|       .|.:.|.........|    :|.|.|.|      |
Frog  3279 TKDLLCGGSYNATSTSVTTSSPN-------FPNLYPPFTSCMWIIDAPVKEHVRLSVQ------S 3330

  Fly  1121 FDMRPSTSAASAEEARESDGSPDKLVINELIYGARISPDKLSLKESQTPPALVPPPIGPR----- 1180
            |.:             ::||.              .|.:.:.||:|         |:|.:
Frog  3331 FRL-------------QTDGD--------------CSQNYIELKDS---------PVGDQGQVRR 3359

  Fly  1181 ---SPTIEIP----MGPTAGGIRRS----------FQLSAIDCDIGSRKSVDSFDLISQ------ 1222
               :.|..||    .|.||..:.:|          |.....:|   ||:...:|..:..
Frog  3360 YCGTETFGIPDFYSYGQTAVVVFKSQNYMQGNGFIFTYQTANC---SREYNQTFGYLKSPGWPEN 3421

  Fly  1223 --------AVEQLPPPAEESEAEASDSLQASVISRLSEAKAVQNNR------ISEMSAESLVWLS 1273
                    .|.:.||....|....|.|::|:..|...:...|:|..      |.:...::|.
Frog  3422 YPHNAECTTVLRAPPNHTISLFFNSFSIEATSSSICYDFLEVRNGSDSNSPLIGKYCGDTLP--- 3483

  Fly  1274 HRLGPVLTSRFITRNLLKL-----LSLCYVGQENLLPEVDDGGSSFNSSPDAANLNYF----SIA 1329
               .|:    |...|:|:|     |.|...|.|          .::.|||:|.....|    |..
Frog  3484 ---DPI----FSKNNVLRLFFKSDLVLSSRGYE----------ITWTSSPNACGGTLFGDHGSFT 3531

  Fly  1330 NARVVGDRSAARVLECLMSIAALYGE----NFLLL 1360
            :....|  |.:....|..:|.|..|.    ||.:|
Frog  3532 SPSYPG--SYSNNTNCEWTILAPLGRLITLNFAVL 3564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr81	NP_609535.1	Beach	345..588	CDD:100117	37/245 (15%)
		WD40	<1644..1877	CDD:225201
		WD40	1651..1876	CDD:295369
		WD40 repeat	1662..1705	CDD:293791
		WD40 repeat	1710..1744	CDD:293791
		WD40 repeat	1752..1788	CDD:293791
		WD40 repeat	1799..1836	CDD:293791
cubn	XP_012821080.2	cubilin_NTD	28..133	CDD:412063
		EGF_CA	<138..166	CDD:238011
		EGF_CA	169..210	CDD:238011
		EGF_CA	262..305	CDD:214542
		EGF_CA	306..349	CDD:214542
		EGF_3	354..388	CDD:403986
		EGF_CA	398..432	CDD:238011
		EGF_CA	434..470	CDD:238011
		CUB	476..589	CDD:238001
		CUB	594..705	CDD:238001
		CUB	712..821	CDD:395345
		CUB	825..935	CDD:238001
		CUB	940..1052	CDD:238001
		CUB	1059..1167	CDD:238001
		CUB	1174..1283	CDD:238001
		CUB	1287..1399	CDD:238001
		CUB	1402..1515	CDD:238001
		CUB	1521..1631	CDD:238001
		CUB	1634..1749	CDD:238001
		CUB	1754..1864	CDD:238001
		CUB	1868..1976	CDD:238001
		CUB	1994..2104	CDD:238001
		CUB	2108..2228	CDD:238001
		CUB	2233..2347	CDD:238001
		CUB	2352..2461	CDD:238001	2/2 (100%)
		CUB	2468..2580	CDD:238001	22/127 (17%)
		CUB	2586..2702	CDD:238001	23/123 (19%)
		CUB	2705..2816	CDD:238001	29/167 (17%)
		CUB	2821..2931	CDD:238001	27/182 (15%)
		CUB	2933..3041	CDD:238001	25/144 (17%)
		CUB	3044..3154	CDD:395345	22/130 (17%)
		CUB	3164..3279	CDD:238001	26/158 (16%)
		CUB	3284..3399	CDD:238001	32/163 (20%)
		CUB	3402..3514	CDD:238001	25/134 (19%)
		CUB	3519..3631	CDD:238001	11/48 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165171147
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930