Protein Alignment escl and EED

DIOPT Version :9

• Sequence 1: NP_001285857.1
• Gene: escl / 34611
• FlyBaseID: FBgn0032391
• Length: 462
• Species: Drosophila melanogaster
• Sequence 2: NP_001294936.1
• Gene: EED / 8726
• HGNCID: 3188
• Length: 466
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 245/501 - (48%)
• Similarity: 315/501 - (62%)
• Gaps: 76/501 - (15%)

  Fly     1 MTETNPSEISPPSEEPPAEDESTDHSPAEAVLSNNSSSVCNVVEPDDEHEVNSVDREDTASLFST 65
            |:|...|.....::.|.|:.:.         ||::.:|     .||    ::..:.:|..|:.|.
Human     1 MSEREVSTAPAGTDMPAAKKQK---------LSSDENS-----NPD----LSGDENDDAVSIESG 47

  Fly    66 TTT---TTRSKSPNTRKLNRLCRRIKAP--------KMVQPLYKYS----SHVREDHNHQIFGVQ 115
            |.|   .|.:.:||            ||        |......|||    :.::||||..:||||
Human    48 TNTERPDTPTNTPN------------APGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQ 100

  Fly   116 FNPFLDRGQPQVFATVGKDRVSIYECERSTGQESCEGIRLLQVYADPDTDESFYTCAWSYDSVTG 180
            ||.....|.|.||||||.:||::||| .|.|:     |||||.|.|.|.||:||||||:|||.|.
Human   101 FNWHSKEGDPLVFATVGSNRVTLYEC-HSQGE-----IRLLQSYVDADADENFYTCAWTYDSNTS 159

  Fly   181 DPVLAAAGYRGVIRIFNPVKHQCSKNYIGHGHAINELKFHPTRPQLLLSGSKDHSLRLWNIQSDV 245
            .|:||.||.||:|||.||:..||.|:|:|||:|||||||||..|.||||.||||:|||||||:|.
Human   160 HPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDT 224

  Fly   246 CVAVFGGVEGHRDEVLSVDFDLRGDRIMSSGMDHSLKLWRLDKPDIKEAIELSSGFSPNKNTGPF 310
            .||:|||||||||||||.|:||.|::|||.||||||||||::...:..||:.|..::|||...||
Human   225 LVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPF 289

  Fly   311 PTIKEHFPDFSTRDIHRNYVDCVQWFGDFVFSK-------------------------SCENSIV 350
            .:.|.||||||||||||||||||:|.||.:.||                         ||||:||
Human   290 ISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSGRAILHSHQQCMRDPVSPNLRQHLSCENAIV 354

  Fly   351 CWKPGKLSESWHEIKPQESATTVLHHFDYKMCEIWFVRFAFNAWQKILALGNQLGTTFVWELDCN 415
            ||||||:.:...:|||.||..|:|..|||..|:||::||:.:.|||:||||||:|..:||:|:..
Human   355 CWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVE 419

  Fly   416 DPNLTKCSQLVHPKSNSTIRQTSFSKDGSILVCVCDDSTVWRWDRV 461
            ||:..||:.|.|.|..:.|||||||:|.|||:.||||:::|||||:
Human   420 DPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRL 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
escl	NP_001285857.1	WD40	96..459	CDD:225201	221/391 (57%)
		WD40	107..352	CDD:295369	158/269 (59%)
		WD40 repeat	111..158	CDD:293791	25/46 (54%)
		WD40 repeat	169..209	CDD:293791	25/39 (64%)
		WD40 repeat	214..251	CDD:293791	27/36 (75%)
		WD40	253..>459	CDD:295369	123/230 (53%)
		WD40 repeat	261..323	CDD:293791	34/61 (56%)
		WD40 repeat	330..378	CDD:293791	28/72 (39%)
		WD40 repeat	386..426	CDD:293791	19/39 (49%)
		WD40 repeat	434..458	CDD:293791	16/23 (70%)
EED	NP_001294936.1	WD40 repeat	96..140	CDD:293791	27/49 (55%)
		WD40 repeat	148..188	CDD:293791	25/39 (64%)
		WD40	150..463	CDD:421866	180/312 (58%)
		WD40 repeat	193..230	CDD:293791	27/36 (75%)
		WD40 repeat	240..302	CDD:293791	34/61 (56%)
		WD40 repeat	309..382	CDD:293791	28/72 (39%)
		WD40 repeat	390..430	CDD:293791	19/39 (49%)
		WD40 repeat	438..462	CDD:293791	16/23 (70%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141256
Domainoid	1	1.000	236	1.000	Domainoid score	I2346
eggNOG	1	0.900	-	-		E1_KOG1034
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2814
Inparanoid	1	1.050	488	1.000	Inparanoid score	I1435
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59795
OrthoDB	1	1.010	-	-		D1191277at2759
OrthoFinder	1	1.000	-	-		FOG0005723
OrthoInspector	1	1.000	-	-		otm41215
orthoMCL	1	0.900	-	-		OOG6_102885
Panther	1	1.100	-	-	LDO	PTHR10253
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2640
SonicParanoid	1	1.000	-	-		X4715
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800