Protein Alignment escl and mes-6

DIOPT Version :8

• Sequence 1: NP_001285857.1
• Gene: escl / 34611
• FlyBaseID: FBgn0032391
• Length: 462
• Species: Drosophila melanogaster
• Sequence 2: NP_001021320.1
• Gene: mes-6 / 177657
• WormBaseID: WBGene00003224
• Length: 459
• Species: Caenorhabditis elegans
• Alignment Length: 476
• Identity: 123/477 (26%)
• Similarity: 195/477 (41%)
• Gaps: 113/477 (24%)

  Fly    69 TTRSKSPNTRKLNRLCRRI-KAPKMVQPLYKYSSHVREDHNHQIFGVQFNPFLDRGQPQVFATVG 132
            |.:.||.|....:|..... |.|      :..::.:.||....|:|..||.:....:.|..||||
 Worm     4 TKKFKSLNLHGFDRSTEDYGKRP------FVLTAKLLEDQKKAIYGCAFNQYAGIDEEQAVATVG 62

  Fly   133 KDRVSIY-------------ECERSTGQESCEGIRLLQVYADPDTDESFYTCAWSYDS------- 177
            ...:.:|             .|...|.:.|           ..:.:||.:|..|.||:
 Worm    63 GSFLHMYSVPIDINNIELQWSCNFPTDKSS-----------KVEREESLFTVTWCYDTYEAENDR 116

  Fly   178 -----VTGDPVLAAAGYRGVIRIFNPVKHQCSKNYIGHGHAINELKFHPTRPQLLLSGSKDHSLR 237
                 |||       |..|.|.:.:.|..:.|......|..||:::..|....|::..|.|.|:|
 Worm   117 NPFKVVTG-------GTLGHIYVIDYVSRKLSNRLRSVGWEINDIRTCPANSNLIVCASSDQSIR 174

  Fly   238 LWNIQSDVCVAVFGGVEGHRDEVLSVDFDLRGDRIMSSGMDHSLKLWRLDKPDIKEAIE------ 296
            :.:|:::.|:.|.||:|.|...:||||:...||.|:|.|.||.|..|.|....:||.:|
 Worm   175 IHHIRNEACLIVIGGLECHAGTILSVDWSTDGDFILSCGFDHQLMEWDLSVKQVKEHLERACKAL 239

  Fly   297 ----------------LSSGFS---------PNKNTG----------PFPT--IKEHFPDFSTRD 324
                            :|.|..         |:|...          |.|:  :..:.|...:.|
 Worm   240 HQDKINVLTQSQDIPYVSKGTMRKSAVSRNIPDKEEDQLLELHRELIPRPSCLLPIYTPSSVSTD 304

  Fly   325 IHRNYVDCVQWF--GDFVFSKSC--ENSIVCWK----PGKLSESWH--EIKPQESATTVLHHFDY 379
            :|.:||||:::.  .::..||.|  |.:|..|:    .|::....|  .::| :|.||.....:.
 Worm   305 MHSDYVDCIRFLIGTNYALSKGCGNEKAIHFWRFGPPKGEVENRIHGNVLRP-KSCTTKFRTMNV 368

  Fly   380 KMCEIWFVRFAFNAWQKILALGNQLGTTFVWELDCND---PNLTKCSQLVHPKSNSTIRQTSFSK 441
            .....||::||.:..::.|..|...|:...::|..|:   |..| ||     ..:.|:||.|||.
 Worm   369 PSGSAWFIKFAVDPRRRWLVCGGAGGSVMFFDLRNNEETNPTHT-CS-----VGSRTVRQASFST 427

  Fly   442 DGSILVCVCDDSTVWRWDRVN 462
            .|..||.|.|:..|.|:|||:
 Worm   428 CGRFLVLVTDEGFVCRFDRVS 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
escl	NP_001285857.1	WD40	96..459	CDD:225201	113/444 (25%)
		WD40	107..352	CDD:295369	78/317 (25%)
		WD40 repeat	111..158	CDD:293791	13/60 (22%)
		WD40 repeat	169..209	CDD:293791	12/52 (23%)
		WD40 repeat	214..251	CDD:293791	11/37 (30%)
		WD40	253..>459	CDD:295369	70/262 (27%)
		WD40 repeat	261..323	CDD:293791	24/105 (23%)
		WD40 repeat	330..378	CDD:293791	15/58 (26%)
		WD40 repeat	386..426	CDD:293791	12/43 (28%)
		WD40 repeat	434..458	CDD:293791	12/24 (50%)
mes-6	NP_001021320.1	WD40	<112..373	CDD:225201	66/269 (25%)
		WD40	120..433	CDD:295369	87/327 (27%)
		WD40 repeat	152..192	CDD:293791	13/40 (33%)
		WD40 repeat	197..233	CDD:293791	16/36 (44%)
		WD40 repeat	245..280	CDD:293791	4/35 (11%)
		WD40 repeat	310..367	CDD:293791	15/58 (26%)
		WD40 repeat	375..415	CDD:293791	12/46 (26%)
		WD40 repeat	420..444	CDD:293791	12/24 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C198448521
eggNOG	1	0.900				E1_KOG1034
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	128	1.000	Inparanoid score	I3203
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010
OrthoDB	1	1.010				D1191277at2759
OrthoFinder	1	1.000				FOG0005209
OrthoInspector	1	1.000				T374628
orthoMCL	1	0.900				OOG5_130364
Panther	1	1.100			LDO	PTHR10253
Phylome	1	0.910		0.667	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R2640
TreeFam	1	0.960
	13	12.800