DRSC/TRiP Functional Genomics Resources

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Protein Alignment esc and LRWD1

DIOPT Version :10

Sequence 1:NP_477431.1 Gene:esc / 34595 FlyBaseID:FBgn0000588 Length:425 Species:Drosophila melanogaster
Sequence 2:NP_690852.1 Gene:LRWD1 / 222229 HGNCID:21769 Length:647 Species:Homo sapiens


Alignment Length:432 Identity:99/432 - (22%)
Similarity:160/432 - (37%) Gaps:114/432 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSDKVKNGNEPEESEESCGDESASYTTNSTTSRSKSPSSSTRSKRRGRRSTKS------------ 54
            |..:|:..|.||:..|:    .|::...:..:..|.|.....|....:|:..|            
Human   203 SRTQVQKANSPEKPPEA----GAAHKPRARLAALKRPDDVPLSLSPSKRACASPSAQVEGSPVAG 263

  Fly    55 KPKSRAAYKYD-THVKENHGAN---------IFGVAFNTLLGKDEP--------QVFATAGSNRV 101
            ...|:.|.|.: .|..:.|..|         ::..||       ||        |..||.|...|
Human   264 SDGSQPAVKLEPLHFLQCHSKNNSPQDLETQLWACAF-------EPAWEEGATSQTVATCGGEAV 321

  Fly   102 TVYECPRQGGMQLLHCYADPDPDEVFYTCAWSYDL-------KTSSPLLAAAGYRGVIRVIDVEQ 159
            .|.:|  |.|: :||.|  ..|.|.|::.||:..:       |....:|||||.||::|::.|..
Human   322 CVIDC--QTGI-VLHKY--KAPGEEFFSVAWTALMVVTQAGHKKRWSVLAAAGLRGLVRLLHVRA 381

  Fly   160 NEAVGNYIGHGQAINELKFHPHKLQLLLSGSKDHAIRLWNIQSHVCIAILGGV-----EGHRDEV 219
            ....|....|.:||..|.|.|.....|.:.|.|..|.||:|          ||     |....::
Human   382 GFCCGVIRAHKKAIATLCFSPAHETHLFTASYDKRIILWDI----------GVPNQDYEFQASQL 436

  Fly   220 LSIDFNMRGDRI--VSSGMDHSLKLWC----------LNTPEFHHKIELSNTFSQ--EKSTLPFP 270
            |::|......|:  |:|..|..|...|          |:.|:.....|:...||:  |.|.....
Human   437 LTLDTTSIPLRLCPVASCPDARLLAGCEGGCCCWDVRLDQPQKRRVCEVEFVFSEGSEASGRRVD 501

  Fly   271 TVTKHFPDFSTRDIHRNYVDCVQWFGNFVLSKSCENAIVC---WKP---GQLHQSFEQVKPSDSS 329
            .:.     |...||              |.||......:|   |:.   |:..||...|      
Human   502 GLA-----FVNEDI--------------VASKGSGLGTICLWSWRQTWGGRGSQSTVAV------ 541

  Fly   330 CTIIAEFEYDECEIWFVRFGFNPWQKVIALGNQQGKVYVWEL 371
             .::|..::...|:.:......|.:.::..|:::|.|:::::
Human   542 -VVLARLQWSSTELAYFSLSACPDKGIVLCGDEEGNVWLYDV 582

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
escNP_477431.1 WD40 72..420 CDD:441893 83/349 (24%)
WD40 repeat 76..122 CDD:293791 16/53 (30%)
WD40 repeat 128..168 CDD:293791 13/46 (28%)
WD40 repeat 173..210 CDD:293791 11/36 (31%)
WD40 repeat 220..282 CDD:293791 16/75 (21%)
WD40 repeat 289..337 CDD:293791 10/53 (19%)
WD40 repeat 345..386 CDD:293791 4/27 (15%)
WD40 repeat 393..417 CDD:293791
LRWD1NP_690852.1 LRR <19..>123 CDD:443914
LRR 1 22..43
leucine-rich repeat 23..48 CDD:275378
LRR 2 48..69
leucine-rich repeat 49..70 CDD:275378
LRR 3 70..91
leucine-rich repeat 71..92 CDD:275378
LRR 4 92..113
leucine-rich repeat 93..106 CDD:275378
WD40 167..584 CDD:441893 99/432 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 204..267 11/66 (17%)
WD 1 282..335 17/62 (27%)
WD40 repeat 295..337 CDD:293791 16/53 (30%)
WD 2 341..379 12/37 (32%)
WD40 repeat 343..390 CDD:293791 13/46 (28%)
WD 3 383..422 13/38 (34%)
WD40 repeat 395..438 CDD:293791 14/52 (27%)
WD 4 426..472 9/45 (20%)
WD40 repeat 452..490 CDD:293791 7/37 (19%)
WD 5 484..526 12/60 (20%)
WD40 repeat 500..548 CDD:293791 13/73 (18%)
WD 6 542..582 6/39 (15%)
WD40 repeat 556..606 CDD:293791 4/27 (15%)
WD 7 598..646
WD40 repeat 615..644 CDD:293791
Blue background indicates that the domain is not in the aligned region.

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