Protein Alignment esc and Eed

DIOPT Version :10

• Sequence 1: NP_477431.1
• Gene: esc / 34595
• FlyBaseID: FBgn0000588
• Length: 425
• Species: Drosophila melanogaster
• Sequence 2: NP_068676.1
• Gene: Eed / 13626
• MGIID: 95286
• Length: 441
• Species: Mus musculus
• Alignment Length: 422
• Identity: 217/422 - (51%)
• Similarity: 299/422 - (70%)
• Gaps: 8/422 - (1%)

  Fly     1 MSSDKVKNGNEPEESEESCGDESASYTTNSTTSRSKSPSSSTRSKRR---GRRSTKSKPKSRAAY 62
            :|||  :|.|.....:|:  |::.|..:.:.|.|..:|:::..:..|   |:...||| |.:.::
Mouse    23 LSSD--ENSNPDLSGDEN--DDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSK-KCKYSF 82

  Fly    63 KYDTHVKENHGANIFGVAFNTLLGKDEPQVFATAGSNRVTVYECPRQGGMQLLHCYADPDPDEVF 127
            |....:||:|...:|||.||....:.:|.||||.||||||:|||..||.::||..|.|.|.||.|
Mouse    83 KCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENF 147

  Fly   128 YTCAWSYDLKTSSPLLAAAGYRGVIRVIDVEQNEAVGNYIGHGQAINELKFHPHKLQLLLSGSKD 192
            |||||:||..||.||||.||.||:||:|:....:.:.:|:|||.|||||||||....||||.|||
Mouse   148 YTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKD 212

  Fly   193 HAIRLWNIQSHVCIAILGGVEGHRDEVLSIDFNMRGDRIVSSGMDHSLKLWCLNTPEFHHKIELS 257
            ||:||||||:...:||.||||||||||||.|:::.|::|:|.|||||||||.:|:....:.|:.|
Mouse   213 HALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKES 277

  Fly   258 NTFSQEKSTLPFPTVTKHFPDFSTRDIHRNYVDCVQWFGNFVLSKSCENAIVCWKPGQLHQSFEQ 322
            ..::..|:..||.:...||||||||||||||||||:|.|:.:|||||||||||||||::....::
Mouse   278 YDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDK 342

  Fly   323 VKPSDSSCTIIAEFEYDECEIWFVRFGFNPWQKVIALGNQQGKVYVWELDPSDPEGAHMTTLHNS 387
            :|||:|:.||:..|:|.:|:||::||..:.|||::|||||.||:|||:|:..||..|..|||.:.
Mouse   343 IKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHH 407

  Fly   388 RSVATVRQIAFSRDASVLVYVCDDATVWRWNR 419
            :..|.:||.:||||:|:|:.|||||::|||:|
Mouse   408 KCGAAIRQTSFSRDSSILIAVCDDASIWRWDR 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
esc	NP_477431.1	WD40	72..420	CDD:441893	197/348 (57%)
		WD40 repeat	76..122	CDD:293791	25/45 (56%)
		WD40 repeat	128..168	CDD:293791	21/39 (54%)
		WD40 repeat	173..210	CDD:293791	25/36 (69%)
		WD40 repeat	220..282	CDD:293791	27/61 (44%)
		WD40 repeat	289..337	CDD:293791	27/47 (57%)
		WD40 repeat	345..386	CDD:293791	22/40 (55%)
		WD40 repeat	393..417	CDD:293791	14/23 (61%)
Eed	NP_068676.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..72		13/52 (25%)
		Interaction with EZH2	81..441		200/359 (56%)
		WD40 repeat	96..140	CDD:293791	24/43 (56%)
		WD40	<109..439	CDD:441893	190/329 (58%)
		WD40 repeat	148..188	CDD:293791	21/39 (54%)
		WD40 repeat	193..230	CDD:293791	25/36 (69%)
		WD40 repeat	240..302	CDD:293791	27/61 (44%)
		WD40 repeat	309..357	CDD:293791	27/47 (57%)
		WD40 repeat	365..405	CDD:293791	21/39 (54%)
		WD40 repeat	413..437	CDD:293791	14/23 (61%)