Protein Alignment Pde1c and pde4a

DIOPT Version :10

• Sequence 1: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: XP_009298019.1
• Gene: pde4a / 572061
• ZFINID: ZDB-GENE-131125-7
• Length: 777
• Species: Danio rerio
• Alignment Length: 766
• Identity: 205/766 - (26%)
• Similarity: 340/766 - (44%)
• Gaps: 142/766 - (18%)

  Fly   453 YEDMQRNLHYAARVLEAVFIDES-REGCNGNCKNLNCSRHS-----HGRDDQQQDNNNSN----- 506
            |.|..|  |:..::..:..:|.| |.|       |..||.|     ||.......|...|
Zfish    47 YSDTDR--HHHRQIERSNAMDTSDRPG-------LKKSRMSWPSSFHGTTSASMSNCAGNKRYDG 102

  Fly   507 -------RSCSLQEASPGGAGAGVTPGADNQDSIESRT-KGVSQAPQTHSGPTGPPSNTSSE-TI 562
                   ||....:||||.......|.:..::|...|: .....:|:|.|..:...|...:| .|
Zfish   103 ENGPSPGRSPMDSQASPGLVLHPSFPQSQRRESFLYRSDSDYDMSPKTMSRNSSINSEGHAEDLI 167

  Fly   563 AQPAPKLQPALETVRE--SVMEESPSKDPGDKGPPPPASTSTLTSQTTTSSSATAEPSAKAAESQ 625
            ..|..::..:|.|||.  :::..              .:|.|.|.::..:|..|..|:..:.|:.
Zfish   168 VTPFAQVLASLRTVRSNFTILAN--------------VTTPTTTMRSPVTSQPTVPPATLSDETY 218

  Fly   626 AGSAGSS----GSCSNPAAVHRQRRLRTPTWARSMSTNKTR--LADEDDELSEVQPDAVPPEVRE 684
            ...|..:    ..|     :.:...::|......|::||.:  |..|...|||:....  .:|.|
Zfish   219 QQLARETLEELDWC-----LDQLETIQTHRSVSEMASNKFKRMLNRELSHLSEMSRSG--NQVSE 276

  Fly   685 WLASTFTR-----QMATSRRKSDEKPKFRSVAHAIRAGIFVDRMYRRVSSSALT--AFP------ 736
            ::::||..     ::.:...:..|||    ::|       :..:.:...||:||  |.|
Zfish   277 YISTTFLDKQNEVEIPSPTLREREKP----MSH-------ISGVKKLTHSSSLTSAALPRFGVKT 330

  Fly   737 ---PDVVRLLKNLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEE 798
               ..:.|.|.:|:.|..::|.:.|.::.:.:..:.:.:|.....:..|:|.......::..:|:
Zfish   331 EQEDALARELNDLNKWGLNIFHVAEFSNNRPLSCIMFAIFQERDLLKTFRIPVDTFITYVMTLED 395

  Fly   799 GYCRYRN-PYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVM 862
            .|  :.| .|||:|||.||.|:.|..|....|....:||||.|:|.||.:||.:|.|.:|.|.:.
Zfish   396 HY--HANVAYHNSLHAADVTQSTHVLLSTPALDAVFSDLEILAALFAAAIHDVDHPGVSNQFLIN 458

  Fly   863 SGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQ 927
            :.||.||:|||.:||||||.:..|:||.|:..:|..:|::.:.:.||.|||:|||.|||:.|...
Zfish   459 TNSELALMYNDESVLENHHLAVGFKLLHEENCDIFQNLTKRQRQSLRKLVIDMVLATDMSKHMSL 523

  Fly   928 MKAMRQLLTLQEATI----------DKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQG 982
            :..::.::..::.|.          |:.:||..::||.|:|:|.|...|:.:||..::||||:||
Zfish   524 LADLKTMVETKKVTSSGVLMLDHYNDRIQVLRNMVHCADLSNPTKPLAVYRQWTERIMEEFFQQG 588

  Fly   983 DLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLELILAPIAPMNKSKPATLVEH 1047
            |.|:|.|:..||:||::...|.:||:.|||:||.|......|:       :.|..:....||.::
Zfish   589 DKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWGDL-------VHPDAQEILDTLEDN 646

  Fly  1048 ETTANSTTNSAIVIPNSGITPSMDKPRDHRTEA---KTTAAECLARKSVTGTTASKFNIPKPWLT 1109
            .....||      ||.|. :|..|:| |:..|:   |......|..::|.....|..:|.
Zfish   647 RDWYQST------IPQSP-SPPPDRP-DNELESCRNKFQFELTLEGETVQDGPPSHNHIV----- 698

  Fly  1110 CLVENKRIWKEQAVKDAEARALATAAEEAAAAAAAEAEESKPETETADGEQ 1160
                   |..:...||.|              .|.||||.:.|.:..|||:
Zfish   699 -------IHDQDEKKDDE--------------EAEEAEEDEAEEKMEDGEE 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	662..722	CDD:462497	13/66 (20%)
		PDEase_I	807..1027	CDD:459723	94/229 (41%)
pde4a	XP_009298019.1	PDE4_UCR	168..284	CDD:465648	27/136 (20%)
		PDEase_I	403..643	CDD:459723	95/246 (39%)