Protein Alignment Pde1c and PDE1B

DIOPT Version :10

• Sequence 1: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: XP_047284926.1
• Gene: PDE1B / 5153
• HGNCID: 8775
• Length: 537
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 233/509 - (45%)
• Similarity: 325/509 - (63%)
• Gaps: 47/509 - (9%)

  Fly   649 TPTWARSMSTNKTR-LADEDDELSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPKFRSVAH 712
            |.:...::..::|| :.|.:|||.|::.||||.|||:|||||||:|.....|:::|||||||:.|
Human    64 TASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPKFRSIVH 128

  Fly   713 AIRAGIFVDRMYRRVSSSALTAFPPDVVRLLKNLDDWTFDVFALTEAASGQVVKYVAYELFNRYG 777
            |::|||||:||:||..:|....:...|:..|||||.|.||||:|.:||....::.:.:||..|:.
Human   129 AVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHN 193

  Fly   778 SIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASL 842
            .|.:|||....|.:||..:|.||.:|:|||||.:||.||.||:|..|..||:::.|:::|:.|.:
Human   194 LISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAII 258

  Fly   843 LAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRE 907
            .||.:||||||||||:||:.:.||.|::||||:||||||.|:.|||:::||.||..:|:::||.|
Human   259 FAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVE 323

  Fly   908 LRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTM 972
            ||.|||||||.|||:.||||:|.|:..|. |...|||.|.|||:||..|||||.|||.||.|||.
Human   324 LRALVIEMVLATDMSCHFQQVKTMKTALQ-QLERIDKPKALSLLLHAADISHPTKQWLVHSRWTK 387

  Fly   973 LLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLELILAPIA--- 1034
            .|:||||||||.|.||||||||||||.:||||:|||.||||||||:..|::|:.|..:.|:|
Human   388 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLADED 452

  Fly  1035 PMNKSKPATLVEHETTANSTTNSAIVIPNSGITPSMDKPRDHRTEAKTTAAECLARKSVTGTTAS 1099
            ..:|::|:.....                    ||:|      .|......:.::.:|.
Human   453 SKSKNQPSFQWRQ--------------------PSLD------VEVGDPNPDVVSFRST------ 485

  Fly  1100 KFNIPKPWLTCLVENKRIWKEQA---VKDAEARALATAAEEAAAAAAAEAEESK 1150
                   |:..:.|||:.|||:|   :.:..:....:..||.|..:.||.|.::
Human   486 -------WVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQ 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	662..722	CDD:462497	36/60 (60%)
		PDEase_I	807..1027	CDD:459723	136/219 (62%)
PDE1B	XP_047284926.1	PDEase_I_N	78..138	CDD:462497	35/59 (59%)
		PDEase_I	223..450	CDD:459723	138/227 (61%)