Protein Alignment Pde1c and PDE9A

DIOPT Version :10

• Sequence 1: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: NP_002597.1
• Gene: PDE9A / 5152
• HGNCID: 8795
• Length: 593
• Species: Homo sapiens
• Alignment Length: 602
• Identity: 138/602 - (22%)
• Similarity: 244/602 - (40%)
• Gaps: 117/602 - (19%)

  Fly   551 TGPPSNTSSETIAQPAPKLQPALETVRESVMEESPSKDPGDKGPP---PPASTSTLTS----QTT 608
            ||.|.||   ||         :|.|..::::...|:.....:..|   .|.:...|::    :.|
Human    43 TGLPRNT---TI---------SLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRT 95

  Fly   609 TSSSATAEPSAKAAESQAGSAGSSGSCSNPAAVHRQRRLRTPTWARSMSTNKTRLADEDDELSEV 673
            ||...:||                    .|....|...|..|....:..:.:......:.:....
Human    96 TSRGQSAE--------------------RPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQ 140

  Fly   674 QPDAVPPEVREWL-------ASTFTRQMATSRRKSD--------------------EKPKFRSVA 711
            :...:|||..|.:       |..|:|....:..|::                    |..|.:|..
Human   141 EGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDI 205

  Fly   712 HAIRAGI--------------FVDRMYRRVSSSALTAFP-----PDVVRLLKNLDDWTFDVFALT 757
            ..:|..:              |:|...:......:..:|     |:.:..|:..   ||||:...
Human   206 KKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKP---TFDVWLWE 267

  Fly   758 EAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHY 822
            .......::::.::|    |.:..|.|.|..|..:|..|.:.|  ..||:||..|...|.|.::.
Human   268 PNEMLSCLEHMYHDL----GLVRDFSINPVTLRRWLFCVHDNY--RNNPFHNFRHCFCVAQMMYS 326

  Fly   823 CLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFR 887
            .:....|....:..:|...:.||:.||.:|.|..|.:.:.:.:|.|:.|||.:.|||||.:.:|:
Human   327 MVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQ 391

  Fly   888 LLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATIDKQKVL--SL 950
            :|.|.|.||.|::..:.|:::|..:|.::|.|||..|.:.|.:.::.:...:.:.::...|  .:
Human   392 ILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMI 456

  Fly   951 VLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIV 1015
            ::.|||||:..:...|...|...||||:|.|.|.||..|||.:|..||:....|.:||.||.|::
Human   457 LIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVL 521

  Fly  1016 EPSMGVMSDML----ELILAPIAPMN------KSKPATLVEHETTANSTTNSAIVIPNSGITPSM 1070
            .|....::.:.    |::|.|:....      |.....:.|.:...:|.|        ||.|
Human   522 IPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLT--------SGAT--- 575

  Fly  1071 DKPRDHRTEAKTTAAEC 1087
            :|.|:...:.|.:..:|
Human   576 EKSRERSRDVKNSEGDC 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	662..722	CDD:462497	13/100 (13%)
		PDEase_I	807..1027	CDD:459723	70/225 (31%)
PDE9A	NP_002597.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..141		9/73 (12%)
		PDEase_I	311..539	CDD:459723	71/227 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	564..593		9/40 (23%)