Protein Alignment Pde1c and PDE6C

DIOPT Version :10

• Sequence 1: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: NP_006195.3
• Gene: PDE6C / 5146
• HGNCID: 8787
• Length: 858
• Species: Homo sapiens
• Alignment Length: 805
• Identity: 172/805 - (21%)
• Similarity: 294/805 - (36%)
• Gaps: 215/805 - (26%)

  Fly   361 NLSQTEMVVGRD-SADYTAMHSINVGVGNSFLRGDTDIPQESGHSFETPSNMSFTAGQWDTESLP 424
            ||..|.:|||:: .|...|::.:|   .:.|.:.|.::..:..:.......:..|:..::.||.
Human   178 NLLATPIVVGKEVLAVIMAVNKVN---ASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESR- 238

  Fly   425 PVDTPDALNKAAGRIRSLLRRMDHETVAYE--DMQRNLHYAARVLEAVFIDESREGCNGNCKNLN 487
                           ||.:.......|..|  |::|..|.|...:.:.               ||
Human   239 ---------------RSQILMWSANKVFEELTDVERQFHKALYTVRSY---------------LN 273

  Fly   488 CSRHSHGRDDQQQDNNNSNR-SCSLQEASPGGAGAGVTPGADNQDSIESRTKGVSQAPQTHSGPT 551
            |.|:|.|..|..::....:. ...|.|..|                              :.||.
Human   274 CERYSIGLLDMTKEKEFYDEWPIKLGEVEP------------------------------YKGPK 308

  Fly   552 GPPSNTSSETIAQPAPKLQPALETVRESVMEESPSKDPGDKGPPPPASTSTLTSQTTTSSSATA- 615
            .|...             :.....:.:.::.   .|:.....|.|||...||.|...|..:...
Human   309 TPDGR-------------EVNFYKIIDYILH---GKEEIKVIPTPPADHWTLISGLPTYVAENGF 357

  Fly   616 ------EPSAKAAESQAGSAGSSG-----SCSNPAAVHRQRRLRTPTWARSMSTNKTRLADEDDE 669
                  .|:.:....|.|....:|     ..|.|....::..:...|:   .:....:..||.|
Human   358 ICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATF---YNRKDGKPFDEHD- 418

  Fly   670 LSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAGIFVDRMYRRVSSSALTA 734
                          |::..|.|:.:..|...:|...|...:.:  |..|..:.:..:..     |
Human   419 --------------EYITETLTQFLGWSLLNTDTYDKMNKLEN--RKDIAQEMLMNQTK-----A 462

  Fly   735 FPPDVVRLLK-----NLD---------------------------DWTFDVFALTEAASGQVVKY 767
            .|.::..:||     |:|                           ::.|..|.|||..   ::|
Human   463 TPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHG---LIK- 523

  Fly   768 VAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNW 832
            ....||.....:.|||:...:|..:::.|.:||...  .|||..|..:|.||:...|....|..:
Human   524 CGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAV--TYHNWRHGFNVGQTMFTLLMTGRLKKY 586

  Fly   833 LTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNIL 897
            .||||.||.|.||..||.:|.||.|.:.:.|.|..|.|:.. ::||.||...|..||:::..||.
Human   587 YTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGS-SILERHHLEYSKTLLQDESLNIF 650

  Fly   898 SHLSREEFRELRGLVIEMVLGTDMTNHFQQ-------MKAMRQLLTLQEA----TID---KQKVL 948
            .:|::.:|..:..|....::.||:..:|::       :.|..|:.|.:||    |:|   |:.::
Human   651 QNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIM 715

  Fly   949 SLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKEL--GLPFSPLCDRN-NTLVAESQICF 1010
            ::::..||:|...|.|.|..:..:::..||:.|||||:.:  ..|. |:.||| ...:.:.|:.|
Human   716 AMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPI-PMMDRNKRDELPKLQVGF 779

  Fly  1011 IDFIVEPSMGVMSDMLELILAPIAPMNKSKPATLVEHETTANSTTNSAIVIPNSGITPSMDKPRD 1075
            |||:                           .|.|..|.:..          :..|||.:...::
Human   780 IDFV---------------------------CTFVYKEFSRF----------HKEITPMLSGLQN 807

  Fly  1076 HRTEAKTTAAECLARKSVTGTTASK 1100
            :|.|.|:.|.|..|:..|....|.|
Human   808 NRVEWKSLADEYDAKMKVIEEEAKK 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	662..722	CDD:462497	11/59 (19%)
		PDEase_I	807..1027	CDD:459723	74/236 (31%)
PDE6C	NP_006195.3	GAF	80..231	CDD:214500	12/55 (22%)
		GAF	256..443	CDD:214500	42/265 (16%)
		PDEase_I	561..805	CDD:459723	80/282 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	830..858		2/3 (67%)