Protein Alignment Pde1c and PDE4D

DIOPT Version :10

• Sequence 1: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: NP_001098101.1
• Gene: PDE4D / 5144
• HGNCID: 8783
• Length: 809
• Species: Homo sapiens
• Alignment Length: 808
• Identity: 214/808 - (26%)
• Similarity: 354/808 - (43%)
• Gaps: 158/808 - (19%)

  Fly   423 LPPVDTPD-------ALNKAAGRIRSLLRRMDHETVAYEDMQRNLHYAARVLEAVFIDESREGCN 480
            |||...|.       |.:.|.||:|       |.  .|.|.:|.|:..|....:..::      .
Human    81 LPPPPPPPGAARGRYASSGATGRVR-------HR--GYSDTERYLYCRAMDRTSYAVE------T 130

  Fly   481 GNCKNLNCSRHSHGRDDQ---QQDNNNSNRSCSLQEASPGGAGAGVTPGADNQDSIESRTKG-VS 541
            |:...|..||.|.....|   :.|.:|             |..||.:|    .|.:.|...| :.
Human   131 GHRPGLKKSRMSWPSSFQGLRRFDVDN-------------GTSAGRSP----LDPMTSPGSGLIL 178

  Fly   542 QAPQTHS----------------GPTGPPSNTS-------SETIAQPAPKLQPALETVRE----- 578
            ||...||                .|.....|:|       .:.|..|..::..:|.|||.
Human   179 QANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAAL 243

  Fly   579 -SVMEESPSKDPGDKGP---PPPASTSTLTSQTTTS-SSATAEPSAKAAESQAGSAGSSGSCSNP 638
             ::.:.:|||    :.|   .|..:.:|:|.:.... :|.|.|              ....|
Human   244 TNLQDRAPSK----RSPMCNQPSINKATITEEAYQKLASETLE--------------ELDWC--- 287

  Fly   639 AAVHRQRRLRTPTWARSMSTNKTR--LADEDDELSEVQPDAVPPEVREWLASTFTR-----QMAT 696
              :.:...|:|......|::||.:  |..|...|||:....  .:|.|::::||..     ::.:
Human   288 --LDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSG--NQVSEFISNTFLDKQHEVEIPS 348

  Fly   697 SRRKSDEKPKFRSVAHAIRAGIFVDRMYRRVSSSALT--AFPPDVVR------LLKNLDD---WT 750
            ..:|..||.| |.::.       :..:.:.:.||:||  :.|...|:      |.|.|:|   |.
Human   349 PTQKEKEKKK-RPMSQ-------ISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWG 405

  Fly   751 FDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVD 815
            ..||.:.|.:..:.:..:.:.:|.....:..|||....|..:|..:|:.| .....||||:||.|
Human   406 LHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHY-HADVAYHNNIHAAD 469

  Fly   816 VMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENH 880
            |:|:.|..|....|....|||||.|::.|:.:||.:|.|.:|.|.:.:.||.||:|||.:|||||
Human   470 VVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENH 534

  Fly   881 HASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEAT---- 941
            |.:..|:||:|:..:|..:|::::.:.||.:||::||.|||:.|...:..::.::..::.|
Human   535 HLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGV 599

  Fly   942 ------IDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNN 1000
                  .|:.:||..::||.|:|:|.|...::.:||..::||||||||.|:|.|:..||:||::|
Human   600 LLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHN 664

  Fly  1001 TLVAESQICFIDFIVEPSMGVMSDMLELILAPIAPMNKSKPATLVEHETTANSTTNSAIVIPNSG 1065
            ..|.:||:.|||:||.|.....:|:       :.|..:....||.::.....||      ||.|.
Human   665 ASVEKSQVGFIDYIVHPLWETWADL-------VHPDAQDILDTLEDNREWYQST------IPQSP 716

  Fly  1066 ITPSMDKPRDHRT-EAKTTAAECLARKSVTGTTASKFNIPKPWLTCLVENKRIWKEQAVKDAEAR 1129
             :|:.|.|.:.|. :.:....|....:.....|...........|...::|.:    ..:|:|:.
Human   717 -SPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTL----CTQDSEST 776

  Fly  1130 ALATAAEEAAAAAAAEAEESKPETETAD 1157
            .: ...|:....|..|.|||:||....|
Human   777 EI-PLDEQVEEEAVGEEEESQPEACVID 803

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	662..722	CDD:462497	14/66 (21%)
		PDEase_I	807..1027	CDD:459723	92/229 (40%)
PDE4D	NP_001098101.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..107		9/32 (28%)
		PDE4_UCR	223..339	CDD:465648	30/140 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	343..364		5/28 (18%)
		PDEase_I	461..701	CDD:459723	93/246 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	710..729		9/25 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	739..809		14/70 (20%)