Protein Alignment Pde1c and PDE4C

DIOPT Version :10

• Sequence 1: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: NP_000914.2
• Gene: PDE4C / 5143
• HGNCID: 8782
• Length: 712
• Species: Homo sapiens
• Alignment Length: 802
• Identity: 197/802 - (24%)
• Similarity: 321/802 - (40%)
• Gaps: 173/802 - (21%)

  Fly   432 LNKAAGRIRSLLRRMDHETVAYEDMQRNLHYAARVLEAVFIDESREGCNGNCKNLNCSRHSHGRD 496
            |:::.|| .|:.|...|       :.|......|:.:..:.|..:   :..|:..:.|.....|.
Human    16 LSRSRGR-HSMTRAPKH-------LWRQPRRPIRIQQRFYSDPDK---SAGCRERDLSPRPELRK 69

  Fly   497 DQQQDNNNSNRSCSLQEASPGGAGAGVTPGADNQDSIESRTKG-VSQAPQTHS------------ 548
            .:.....:|.|...|:.        |::.|....|...|...| :.|||..||
Human    70 SRLSWPVSSCRRFDLEN--------GLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDS 126

  Fly   549 ----GPTGPPSNTS-------SETIAQPAPKLQPALETVRESV-----------MEESPSKDPGD 591
                .|.....|:|       .:.|..|..::..:|.|||.:|           .::.|..:|..
Human   127 DYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSS 191

  Fly   592 KGPPPPASTSTLTSQTTTSSSATAEPSAKAAESQAGSAGSSGSCSNPAAVHRQRRLRTPTWARSM 656
            ....|||.        .|......|           :......|     :.:...|:|......|
Human   192 SNQLPPAE--------DTGQKLALE-----------TLDELDWC-----LDQLETLQTRHSVGEM 232

  Fly   657 STNKTR--LADEDDELSEVQPDAVPPEVREWLASTFTRQ---MATSRRKSDEKPK-------FRS 709
            ::||.:  |..|...|||.....  .:|.|:::.||..|   :...:..::|.|:       ...
Human   233 ASNKFKRILNRELTHLSETSRSG--NQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHG 295

  Fly   710 VAHAIRAGIFVDRMYRRVSSSALTAF---PPDVVRLLKNLDD---WTFDVFALTEAASGQVVKYV 768
            :.|:           ..:||:.:..|   .....:|.|.|:|   |..|||.:.|.:..:.:..:
Human   296 LCHS-----------ASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAI 349

  Fly   769 AYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWL 833
            .:.:|.....:..|:|....|..:|..: ||:......|||:|||.||.|:.|..|....|....
Human   350 IFSIFQERDLLKTFQIPADTLATYLLML-EGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVF 413

  Fly   834 TDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILS 898
            |||||.|:|.|:.:||.:|.|.:|.|.:.:.||.||:|||.:||||||.:..|:||:.:..:|..
Human   414 TDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQ 478

  Fly   899 HLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEAT----------IDKQKVLSLVLH 953
            :||.::...||.:||:|||.|||:.|...:..::.::..::.|          .|:.:||..::|
Human   479 NLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVH 543

  Fly   954 CCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPS 1018
            |.|:|:|.|...::.:||..::.|||:|||.|:|.||..||:||::...|.:||:.|||:|..|.
Human   544 CADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPL 608

  Fly  1019 MGVMSDMLELILAPIAPMNKSKPATLVEHETTANSTTNSAIVIPNSGITPSMDKPRDHRTEAKTT 1083
            ....:|:       :.|..:....||.::.....|....:   |:....|..|.|...:.|....
Human   609 WETWADL-------VHPDAQDLLDTLEDNREWYQSKIPRS---PSDLTNPERDGPDRFQFELTLE 663

  Fly  1084 AAECLARKSVTGTTASKFNIPKPWLTCLVENKRIWKEQAVKDAEARALATAAEEAAAAAAAEAEE 1148
            .||                          |.    .|:..::.|..|||..|.|.
Human   664 EAE--------------------------EE----DEEEEEEGEETALAKEALEL---------- 688

  Fly  1149 SKPETETADGEQS-EPAAEPAD 1169
              |:||....|.. :|...|.|
Human   689 --PDTELLSPEAGPDPGDLPLD 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	662..722	CDD:462497	13/71 (18%)
		PDEase_I	807..1027	CDD:459723	91/229 (40%)
PDE4C	NP_000914.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		5/15 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	45..64		3/21 (14%)
		PDE4_UCR	152..268	CDD:465648	28/141 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	181..200		5/26 (19%)
		PDEase_I	387..627	CDD:459723	92/246 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	636..655		5/21 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	664..712		17/87 (20%)