DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pde1c and PDE4B

DIOPT Version :10

Sequence 1:NP_001137817.1 Gene:Pde1c / 34594 FlyBaseID:FBgn0264815 Length:1173 Species:Drosophila melanogaster
Sequence 2:NP_002591.2 Gene:PDE4B / 5142 HGNCID:8781 Length:736 Species:Homo sapiens


Alignment Length:600 Identity:162/600 - (27%)
Similarity:280/600 - (46%) Gaps:90/600 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   540 VSQAPQTHSGPTGPPSNTSSETIAQPAPKLQPALETVRESVMEES-----------------PSK 587
            |...|.....|..|.:::|:..:....   .|.....|||.:..|                 ||:
Human    97 VENGPSPGRSPLDPQASSSAGLVLHAT---FPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSE 158

  Fly   588 DPGDKGPPPPASTSTLTSQTTTSSSATAEPSAKAAESQAGSAGSSGSCS--NPAAVHRQR----- 645
            ..||.....|.: ..|.|..:..::.|...:.....::...|.|....|  ||.....|:     
Human   159 QHGDDLIVTPFA-QVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMET 222

  Fly   646 ---------RLRTPTWARS---MSTNKTR--LADEDDELSEVQPDAVPPEVREWLASTFTR---- 692
                     :|.|....||   |::||.:  |..|...|||:....  .:|.|::::||..    
Human   223 LEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSG--NQVSEYISNTFLDKQND 285

  Fly   693 -QMATSRRKSDEKPKFRSVAHAIRAGIFVDRMYRRVSSSAL-----------TAFPPDVVRLLKN 745
             ::.:..:|..||.|.:.:...| :|:     .:.:.||:|           |.....:.:.|::
Human   286 VEIPSPTQKDREKKKKQQLMTQI-SGV-----KKLMHSSSLNNTSISRFGVNTENEDHLAKELED 344

  Fly   746 LDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNN 810
            |:.|..::|.:...:..:.:..:.|.:|.....:..|:|:......::..:|:.| .....|||:
Human   345 LNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHY-HSDVAYHNS 408

  Fly   811 LHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRA 875
            |||.||.|:.|..|....|....|||||.|::.||.:||.:|.|.:|.|.:.:.||.||:|||.:
Human   409 LHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDES 473

  Fly   876 VLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEA 940
            ||||||.:..|:||:|:..:|..:|::::.:.||.:||:|||.|||:.|...:..::.::..::.
Human   474 VLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKV 538

  Fly   941 T----------IDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPL 995
            |          .|:.:||..::||.|:|:|.|...::.:||..::||||:|||.|:|.|:..||:
Human   539 TSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPM 603

  Fly   996 CDRNNTLVAESQICFIDFIVEPSMGVMSDMLELILAPIAPMNKSKPATLVEHETTANSTTNSAIV 1060
            ||::...|.:||:.|||:||.|.....:|:::       |..:....||.::.....|      :
Human   604 CDKHTASVEKSQVGFIDYIVHPLWETWADLVQ-------PDAQDILDTLEDNRNWYQS------M 655

  Fly  1061 IPNSGITPSMDKPRD 1075
            ||.|...|..::.||
Human   656 IPQSPSPPLDEQNRD 670

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pde1cNP_001137817.1 PDEase_I_N 662..722 CDD:462497 15/66 (23%)
PDEase_I 807..1027 CDD:459723 92/229 (40%)
PDE4BNP_002591.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 51..78
PDE4_UCR 166..281 CDD:465648 26/117 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 189..209 3/19 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..301 3/18 (17%)
PDEase_I 405..645 CDD:459723 93/246 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 685..736
Blue background indicates that the domain is not in the aligned region.

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