Protein Alignment Pde1c and PDE3B

DIOPT Version :10

• Sequence 1: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: NP_001350499.1
• Gene: PDE3B / 5140
• HGNCID: 8779
• Length: 1190
• Species: Homo sapiens
• Alignment Length: 1173
• Identity: 263/1173 - (22%)
• Similarity: 416/1173 - (35%)
• Gaps: 350/1173 - (29%)

  Fly   202 GPASGTATGT-------------------------GSASGGAGGVSTPAQEAASPTVSELSGSGS 241
            ||..|.:.|:                         |....|:....||.:.||...:..||..|.
Human   142 GPGPGRSCGSWWLLALPACCYLGDFLVWQWWSWPWGDGDAGSAAPHTPPEAAAGRLLLVLSCVGL 206

  Fly   242 NATINGQV-ARHGSLTIIRRTNS--RNFTQFDGQLASPSSTACSSTAPGIG---------FAQTP 294
            ..|:...: .||..|.::..:..  .:||.. |.|.|......|....|.|         |.|.
Human   207 LLTLAHPLRLRHCVLVLLLASFVWWVSFTSL-GSLPSALRPLLSGLVGGAGCLLALGLDHFFQI- 269

  Fly   295 LSEPLAERLSFRAS--------GGSNGSASAGDSRSSNQGPSNSGPAASAAVKMQPSSPNATNYL 351
            ...||..|||..|.        ...:...|.|::.:|..|        |..:..:||.|
Human   270 REAPLHPRLSSAAEEKVPVIRPRRRSSCVSLGETAASYYG--------SCKIFRRPSLP------ 320

  Fly   352 ADNIQISSANLSQTEMVVGRDSADYTAMHSINVGVGNSFLRGDTDIPQESGHSFETPSNMSFTAG 416
                     .:|:.:|::.  ..|....:..:...|..:  .|...||.....|:..|.:|..:
Human   321 ---------CISREQMILW--DWDLKQWYKPHYQAGVQW--HDLGSPQPPAPWFKRFSCLSLRS- 371

  Fly   417 QWDTESLPP--------------------------VDTPDALNKAAG-------------RIRSL 442
            .||...:||                          .|.|.:.:::||             .:.:.
Human   372 SWDYRHVPPHLANFVFLVEMGFLHVGQAGLELPTSGDLPTSASQSAGITGNSGGGNGVDLSVLNE 436

  Fly   443 LRRMDHETVAYEDMQRNLHYAARVLEAVFIDESREGC-NGNCK-NLN----------CS--RHSH 493
            .|.|      ..|:..:.....:|:.::....|..|. :|:|: .:|          ||  ....
Human   437 ARNM------VSDLLTDPSLPPQVISSLRSISSLMGAFSGSCRPKINPLTPFPGFYPCSEIEDPA 495

  Fly   494 GRDDQQQD---NNNSNRSCSLQEASPGGAGAGVTPGADNQDSIESRTKGVSQAPQTHSGPTGP-- 553
            .:.|::.:   |.||..:..|:.:|   ..:|:.|  ..|.|...|..|  :.|....|.:..
Human   496 EKGDRKLNKGLNRNSLPTPQLRRSS---GTSGLLP--VEQSSRWDRNNG--KRPHQEFGISSQGC 553

  Fly   554 ----PSNTSSETIAQPAPKLQPALETV-------RESVMEESPSKDPGDKGPPPPASTSTLTSQT 607
                |.|::..||    ||.:.:..::       |..|:.   |..|.:.....|.||.:||:::
Human   554 YLNGPFNSNLLTI----PKQRSSSVSLTHHVGLRRAGVLS---SLSPVNSSNHGPVSTGSLTNRS 611

  Fly   608 TTSSSATAE----PSAKAAESQAGSAGSSGSCSNPAAVHRQRRLRTPTWARS--------MSTNK 660
            ......||:    ||.....       |.|:..|....::|.|........|        :||::
Human   612 PIEFPDTADFLNKPSVILQR-------SLGNAPNTPDFYQQLRNSDSNLCNSCGHQMLKYVSTSE 669

  Fly   661 T--------RLADEDDELSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAG 717
            :        :..:|::..|:               .:| :.|.|.:.:..||...|.:   .:.|
Human   670 SDGTDCCSGKSGEEENIFSK---------------ESF-KLMETQQEEETEKKDSRKL---FQEG 715

  Fly   718 IFVDR-MYRRVSSSALTAFPPDVV----------RLLKNLDDWTFDVFALTE---AASGQVVKYV 768
               |: :.....|...|....:|.          .|::.:.:|.|.:|.|.|   ..||:::..|
Human   716 ---DKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQV 777

  Fly   769 AYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRN-PYHNNLHAVDVMQTIHYCL-------- 824
            .|.||...|.:..|||.......:...:|.|   ||: ||||.:||.||:..:.|..
Human   778 MYTLFQDTGLLEIFKIPTQQFMNYFRALENG---YRDIPYHNRIHATDVLHAVWYLTTRPVPGLQ 839

  Fly   825 -----CNTG-------------------------------LMNWLTDLEIFASLLAALLHDYEHT 853
                 |.||                               |.:.:..||:.|..:||.:|||:|.
Human   840 QIHNGCGTGNETDSDGRINHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHP 904

  Fly   854 GTTNNFHVMSGSETALLYNDRAVLENHHASASFRL-LREDEYNILSHLSREEFRELRGLVIEMVL 917
            |.||.|.|.:.:..|:|||||:|||||||::::.| |...|||.|.||...||:..|.||||.:|
Human   905 GRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAIL 969

  Fly   918 GTDMTNHFQ---QMKAMRQLLTLQEATIDKQKVLSLVLHCC----DISHPAKQWGVHHRWTMLLL 975
            .||:..||.   :..|....:.........:....||...|    ||:.|||...:|.:||..::
Human   970 ATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIV 1034

  Fly   976 EEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLELILAPIAPMNKSK 1040
            .||:.|||.|..||||.||..||::..:|:.|..||..||                  .|:..|.
Human  1035 NEFYEQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIV------------------GPLCNSY 1081

  Fly  1041 PATLVEHETTANSTTNSAIVIPNSGITPS--MDKPRDHRTEAKTTAAECLARKSVTGTTASKFNI 1103
            .|                     :|:.|.  ::...|:.||:.....   ..:..|.....:.|:
Human  1082 DA---------------------AGLLPGQWLEAEEDNDTESGDDED---GEELDTEDEEMENNL 1122

  Fly  1104 -PKP-------WLTC-----LVENKRIWKEQAVKDAEARA----------LATAAEEAAAAAAAE 1145
             |||       .:.|     |.||.:||||...::.:.:|          ....|:|......|:
Human  1123 NPKPPRRKSRRRIFCQLMHHLTENHKIWKEIVEEEEKCKADGNKLQVENSSLPQADEIQVIEEAD 1187

  Fly  1146 AEE 1148
            .||
Human  1188 EEE 1190

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	662..722	CDD:462497	9/59 (15%)
		PDEase_I	807..1027	CDD:459723	91/271 (34%)
PDE3B	NP_001350499.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		Interaction with RAPGEF3. /evidence=ECO:0000269|PubMed:21393242	1..25
		COG5373	<102..>282	CDD:444140	32/141 (23%)
		CynX	<190..263	CDD:442057	17/73 (23%)
		PDEase_I	814..1088	CDD:459723	95/312 (30%)