Protein Alignment Pde1c and pde-6

DIOPT Version :10

• Sequence 1: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: NP_001370828.1
• Gene: pde-6 / 190808
• WormBaseID: WBGene00022389
• Length: 760
• Species: Caenorhabditis elegans
• Alignment Length: 927
• Identity: 214/927 - (23%)
• Similarity: 336/927 - (36%)
• Gaps: 258/927 - (27%)

  Fly   167 EASGGPGSSGGTSGAATSSSSSGG-----------------GAASGAASGSVGPASGTATGTGSA 214
            :.||..|..|..|....|:.|..|                 .|.:.|||..|........|:.|.
 Worm     3 DRSGVGGEEGEKSVLGASAHSQAGRRQQHTPAARRGAQRAPAATAAAASRPVFAMRWCCGGSYSE 67

  Fly   215 SGGAGGVSTPAQEAASPTVSELSGSGSNATINGQVARHGSLTIIRRTNSRNFTQFDGQLASPSST 279
            :||.||.|..|......||:..|.|.::.|......:.....:|       .|:..|:.....|.
 Worm    68 NGGGGGGSRGAPPTPLLTVAATSSSTAHDTFGPMQVKMLKTAVI-------VTEGTGESVLLDSL 125

  Fly   280 ACSSTAPGIGFAQTPLSE-----PLAERLSFRASGGSNGSASAGDSRSSNQGPSNSGPAASAAVK 339
            ..|.....:.|.....|:     |||..:..|.                        |..|...|
 Worm   126 RASGWICTVSFPTQATSDVESICPLAVFIDLRV------------------------PHPSQIAK 166

  Fly   340 MQPSSPNATNYLADNIQISSANLSQTEMVVGRDSADYTAMHSINVGVGNSFLRGDTDIPQESGHS 404
             ..||.:....|.  :.|:..::|:...   |..|....:|.:.
 Worm   167 -DVSSVSTEEVLI--VSIAEKHISEKRR---RALAQSNIIHHVT--------------------- 204

  Fly   405 FETPSNMSFTAGQWDTESLPPVDTPDALNKAAGRIR---SLLRRMDHETVAYE--DMQRNLHYAA 464
                         |:|..   |...|.:.:.|.|||   :|...:|....|.|  |.||.:.|..
 Worm   205 -------------WNTRD---VVLFDYVGRLANRIRALPALFAVLDETDQAVEICDEQRVVQYVN 253

  Fly   465 RVLEAVFIDESREGC---------NGNCKNLNCSRHSHGRDDQQQDNNNSNRSCSLQEASPGGAG 520
            |..|.|      .||         ....:..:..| :.|.::::       |||..:...
 Worm   254 RAYENV------TGCIRSEVIGQPESEMRRKSLPR-ARGEEERR-------RSCDWKFIR----- 299

  Fly   521 AGVTPGADNQDSIESRTKGVSQAPQTHSGPTGPPSNTSSETIAQPAPKLQPALETVRESVMEESP 585
               .|.|:|...:..:.                 |||:.:|.|           ..|:..::...
 Worm   300 ---VPFANNSQFVYMKR-----------------SNTTGDTAA-----------IFRDVSLKSLK 333

  Fly   586 SKDPGDKGPPPPASTSTLTSQTTTSSSATAEPSAKAAESQAGSAGSSGSCSNPAAVHRQRRLRTP 650
            |:..|.:.|    .:..||.....|:....||:....::.              .|.....|..|
 Worm   334 SQTGGIEAP----ISEVLTMLRDVSARVDGEPAQTIKDAM--------------KVLSSHELYAP 380

  Fly   651 TWARSMSTNKTRLADEDDELSEVQPDAVPPEVREWLASTFTRQMATS------RRKSDEKPKFRS 709
                  |.|:.|.||                           ::||.      |.....:.:.||
 Worm   381 ------SINRFRDAD---------------------------RIATQYYDGLIRLHHPARQRKRS 412

  Fly   710 V--AHAIRAGIFVDRMYRRVSSSALTAFPPDVVRLLKNLDDWTFDVFALTEAASGQVVKYVAYEL 772
            |  ||..:.|...:|  ||||:        ||...|:|.:.|.||:..|.:.:....:..|..::
 Worm   413 VVDAHREKRGSHGER--RRVSA--------DVKNALENDNCWKFDILHLEKVSDHHALSQVGMKV 467

  Fly   773 FNRYGSIHKFKIAP--GILEAFLHR----VEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMN 831
            |.|:      |:..  |..:..|||    :|..| ...|.|||..||.||:|...:.|.:..:..
 Worm   468 FERW------KVCDVLGCSDDLLHRWILSIEAHY-HAGNTYHNATHAADVLQATSFFLDSPSVAV 525

  Fly   832 WLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLRED--EY 894
            .:.:....|:||||.:||.:|.|..|.:.:.:....|:||||.::|||||.:.:|:|..:.  ..
 Worm   526 HVNESHAVAALLAAAVHDLDHPGRGNAYLINTRQSLAILYNDNSILENHHIALAFQLTLQHNANV 590

  Fly   895 NILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQL----LTLQEATIDKQKVLSLVLHCC 955
            ||.|.||||||.::|..::||||.||::.||:.:....::    :..::...:...:..:::.|.
 Worm   591 NIFSSLSREEFIQMRHAMVEMVLATDISRHFEYLAKFNKMHVTDVPEEQRDTNSLTICDMLVKCA 655

  Fly   956 DISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFS-PLCDRNNTLVAESQICFIDFIVEPS- 1018
            |||:||::||:..||...::||:|.|...|||.|||.: .:.|||...|..:|..|||.....:
 Worm   656 DISNPAREWGLCQRWAHRIVEEYFEQTREEKEKGLPVTMEVFDRNTCNVPITQCGFIDMFAREAF 720

  Fly  1019 --------MGVMSDMLE 1027
                    :|.:||.||
 Worm   721 ATFTEFAKLGELSDQLE 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	662..722	CDD:462497	12/67 (18%)
		PDEase_I	807..1027	CDD:459723	80/235 (34%)
pde-6	NP_001370828.1	PAS	218..>356	CDD:441804	37/191 (19%)
		RocR	229..>280	CDD:443041	13/56 (23%)
		PDEase_I	501..736	CDD:459723	80/234 (34%)