Protein Alignment Pde1c and pde-4

DIOPT Version :10

• Sequence 1: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: NP_871945.1
• Gene: pde-4 / 174235
• WormBaseID: WBGene00020114
• Length: 674
• Species: Caenorhabditis elegans
• Alignment Length: 702
• Identity: 172/702 - (24%)
• Similarity: 280/702 - (39%)
• Gaps: 191/702 - (27%)

  Fly   507 RSCSLQEASPGGAGAGVTPGADNQDSIES--------RTKGVSQAPQTHSGPTGPPSNTSSETIA 563
            |..|...::.||:|.|   |.....|:..        ||...|.:..:.:.|...|..||:.||.
 Worm     5 RGSSSSSSAAGGSGGG---GGFGFSSLRRELHLHNFFRTSSPSASSTSRTPPAALPPRTSAVTIP 66

  Fly   564 QPAPKLQPALETVRESVMEESPSKDPGDKGPPPPASTSTLTSQTTTSSSATAEPSAKAAESQAGS 628
            ....||..:..:..                  ||..   ||..|.::.||||..         |.
 Worm    67 GSNHKLTSSASSYH------------------PPRE---LTVSTFSAGSATAAD---------GL 101

  Fly   629 AGSSGSCSNPAAVHRQRR---------------LRTPTWARSMSTNK------------------ 660
            .|:..:.|..::||.:|.               ||..:.|.|:::|:
 Worm   102 GGAHLTPSLSSSVHARRESFLYRASDDLREASSLRPVSRASSIASNEHGHGDDLIVTPFAQLLAS 166

  Fly   661 -----------TRLADEDDELSEVQPDAVPP------------------EVREW----------- 685
                       |.:.:.||.....:....||                  |..:|
 Worm   167 LRNVRSNLISITNIQNSDDSRHANRSAKRPPLHNIELPDDVVHCAHDTLEELDWCLDQLETIQTH 231

  Fly   686 -----LASTFTRQM-----------------------ATSRRKSDEKPKFR-----SVAHAIRAG 717
                 :||:..|:|                       .|...|.:::|...     .|.....:|
 Worm   232 RSVSEMASSKFRKMLNKELSHFAESSKSGTQVSKFLITTYMDKEEDEPSIEIEVPTEVQGPSTSG 296

  Fly   718 IFVDRMYRRVSSSALTAF----------------------PPDVVRLLKNLDDWTFDVFALTEAA 760
            .....:.::..::|:...                      ..::...::.||||..|||.:.|.:
 Worm   297 PMTLSILKKAQTAAMNKISGVRKLRAPSHDGHVPEYGVNCAREIAVHMQRLDDWGPDVFKIDELS 361

  Fly   761 SGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLC 825
            ....:..|.:.|..:......|:|....|..:|..:|..|  ..|.|||.:||.||.|::|..|.
 Worm   362 KNHSLTVVTFSLLRQRNLFKTFEIHQSTLVTYLLNLEHHY--RNNHYHNFIHAADVAQSMHVLLM 424

  Fly   826 NTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLR 890
            :..|....||||:.|::.|..:||.:|.|.||.:.:.|.:|.|::|||.:|||.||.:.:|:||:
 Worm   425 SPVLTEVFTDLEVLAAIFAGAVHDVDHPGFTNQYLINSNNELAIMYNDESVLEQHHLAVAFKLLQ 489

  Fly   891 EDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEAT-------------I 942
            :...:.|::|||::..:.|.:||:|||.|||:.|   |..:..|.|:.||.             .
 Worm   490 DSNCDFLANLSRKQRLQFRKIVIDMVLATDMSKH---MSLLADLKTMVEAKKVAGNNVIVLDKYN 551

  Fly   943 DKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQ 1007
            ||.:||..::|..|:|:|.|...::.:|...::||::||||.||||||..||:|||.|..:.:||
 Worm   552 DKIQVLQSMIHLADLSNPTKPIELYQQWNQRIMEEYWRQGDKEKELGLEISPMCDRGNVTIEKSQ 616

  Fly  1008 ICFIDFIVEPSMGVMSDML----ELILAPIAPMNKSKPATLVEHETTANSTT 1055
            :.|||:||.|.....:|::    :.||..:....:...:.:.|...||.:.|
 Worm   617 VGFIDYIVHPLYETWADLVYPDAQNILDQLEENREWYQSRIPEEPDTARTVT 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	662..722	CDD:462497	15/121 (12%)
		PDEase_I	807..1027	CDD:459723	93/236 (39%)
pde-4	NP_871945.1	PDE4_UCR	157..273	CDD:465648	12/115 (10%)
		PDEase_I	406..646	CDD:459723	95/242 (39%)