Protein Alignment Pde1c and LOC1279930

DIOPT Version :10

• Sequence 1: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: XP_061510049.1
• Gene: LOC1279930 / 1279930
• VectorBaseID: AGAMI1_008715
• Length: 1083
• Species: Anopheles gambiae
• Alignment Length: 1248
• Identity: 516/1248 - (41%)
• Similarity: 641/1248 - (51%)
• Gaps: 308/1248 - (24%)

  Fly    59 RDQKRDHSSDGLVSSGELRDEFMGIDAQPRRESL--NSCEVGSPGT-------MSSSLGKAGRLN 114
            |..|:.|.|....||.....:.:....|....::  ||....:.|:       .||::|:.
Mosquito     4 RTVKQCHGSSSSSSSTSSSKDIVITTDQTNETNVTGNSANATADGSARCTNAVKSSNVGEL---- 64

  Fly   115 SSRYPSGGAGAIGLSVMGNLVGTTTRKCVLTL-------------DGYSYVIVASTPESLPSKRD 166
            .:|..|.|.|....:...|    .:||||:..             |...::.|||:||:..:|.|
Mosquito    65 PARTASAGGGRCCDAPQCN----NSRKCVVRQKSQKIVLAPSSGEDHVYHIYVASSPENKFTKDD 125

  Fly   167 EASGGPGSSGGTSGAATSSSSSGGGAASGAASGSVGPASGTA----TGTGSASGGAGGVS-TPAQ 226
            ....|.|...........::..||...|..:.||.||.:...    |.|..|.|.:.|.: :.||
Mosquito   126 ITLAGAGQGREQLSCCDPATCPGGPTTSYGSCGSTGPIASAGPTVPTITPLAGGSSSGTALSHAQ 190

  Fly   227 EAASPTVSELSGSGSNATI---------------------------NGQVARHGSLTIIRRTNSR 264
            :.:|.:..:.....|..:.                           |||:|:.|||||:||||||
Mosquito   191 QQSSTSQQQQQQQQSAGSCYPCHHHFHHHHHHHHCHQPVRADCHSRNGQIAKQGSLTIVRRTNSR 255

  Fly   265 NFTQFDGQLASPSSTACSSTAPGIGFAQTPLSEPLAERLSFRASGGSNGSASAGDSRSSNQGPSN 329
            ..|....||....:...|.      :.|.|   |.........|||..|....|......:|...
Mosquito   256 KNTNIQQQLQYQEALDESE------YQQQP---PYGNDSYTEGSGGGRGGGGGGGGGGGGEGGEG 311

  Fly   330 SGPAASAAVKMQPSSPNATNYLADNIQISSANLSQTEMVVGRDSADYTAMHSINVGVGNSFLRGD 394
            .|..||:..:.....|               .||::|:                 ...||.|..:
Mosquito   312 GGAGASSEAEYGQHHP---------------PLSESEL-----------------AFVNSQLSRE 344

  Fly   395 TDIPQESGHSFETPSNM--SFTAGQWD-----TESLPPVDTPDALNKAAGRIRSLLRRMDHETVA 452
            .:..|.:..:....:|.  |.|..:.|     |::||.||||||.:|||.|:|.|||::....::
Mosquito   345 LESMQPTSGTVSVVANRTESTTGDELDNVDLATDNLPAVDTPDACDKAAVRLRCLLRQLQRGEIS 409

  Fly   453 YEDMQRNLHYAARVLEAVFIDESRE--GCNGNCKNLNCSRHSHGRDDQQQDNNNSNRSCSLQEAS 515
            .|.:|:||||||||||||||||:.:  |..|....                            ..
Mosquito   410 AELLQKNLHYAARVLEAVFIDETNQDGGAGGGGGG----------------------------GG 446

  Fly   516 PGGAGAGVTPGAD--------------NQDSIESRTKGVSQAPQTHSGPTGPPSNTSSETIAQPA 566
            .||.|.|.|.|..              |..|.|......:.||.||.||||||::
Mosquito   447 SGGGGGGATGGGSAGGTGCSGSAAAHGNASSKEPHRGATTSAPPTHGGPTGPPAS---------- 501

  Fly   567 PKLQPALETVRESVMEESPSKDPGDKGPPPPASTSTLTSQTTTSSSATAEPSAKAAESQAGSAGS 631
                                     ||
Mosquito   502 -------------------------KG-------------------------------------- 503

  Fly   632 SGSCSNPAAVHRQRRLRTPTWARSMSTNKTRLADEDDELSEVQPDAVPPEVREWLASTFTRQMAT 696
                     |.::||||.|.|||||     ||||||||||||||||||||||||||||||||:||
Mosquito   504 ---------VIQRRRLRAPVWARSM-----RLADEDDELSEVQPDAVPPEVREWLASTFTRQLAT 554

  Fly   697 SRRKSDEKPKFRSVAHAIRAGIFVDRMYRRVSSSALTAFPPDVVRLLKNLDDWTFDVFALTEAAS 761
            :|:|||||||||||||||||||||||:||||||:||..|||:|||:||.||||:||||||.||.:
Mosquito   555 TRKKSDEKPKFRSVAHAIRAGIFVDRIYRRVSSTALMQFPPEVVRVLKTLDDWSFDVFALAEAGN 619

  Fly   762 GQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCN 826
            .|.|||:.|:|.||||.|||||:.|..||.||.|:||||||:||||||||||.||.||:|:.||.
Mosquito   620 CQPVKYLGYDLLNRYGMIHKFKVPPATLETFLTRIEEGYCRFRNPYHNNLHAADVAQTVHHVLCQ 684

  Fly   827 TGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLRE 891
            ||||:|||||||||:|||||:||||||||||||||||||:||:||||||||||||.||:||:|:|
Mosquito   685 TGLMHWLTDLEIFATLLAALIHDYEHTGTTNNFHVMSGSDTAMLYNDRAVLENHHISAAFRVLKE 749

  Fly   892 DEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATIDKQKVLSLVLHCCD 956
            |:.|:|.:|||:||||||.|:|:|||.|||:.||||:|.||.||||.|..:||.|.|||||||||
Mosquito   750 DDCNVLQNLSRDEFRELRTLIIDMVLATDMSFHFQQLKNMRNLLTLAEPQVDKSKALSLVLHCCD 814

  Fly   957 ISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGV 1021
            ||||||:|.:||:||||||||||||||||:||||||||||||||||||||||.||:|||||||.|
Mosquito   815 ISHPAKRWDIHHKWTMLLLEEFFRQGDLERELGLPFSPLCDRNNTLVAESQIGFIEFIVEPSMTV 879

  Fly  1022 MSDMLELILAPIAPM-----------------------------------------------NKS 1039
            .:||||::||||||:                                               |..
Mosquito   880 CADMLEIVLAPIAPIACNASSSSGGAAASAASAGAGGNSATNNTSSSNSSNSNNNNNNNNNNNNL 944

  Fly  1040 KPATLVEHETTANSTTNSAIVIPNSGITPSMDKPRDHRTEAKTTAAECLARKSVTGTTA------ 1098
            ...|.|.:.::..||||:..|..|:   .:.::.....||..|..|...:..|..|.:|
Mosquito   945 NSNTNVNNNSSIKSTTNTLSVPSNN---TNNNEAISSGTEGGTKDATPSSAPSSAGGSATAKNGS 1006

  Fly  1099 -------SKFNIPKPWLTCLVENKRIWKEQAVKDAEARALATAAEEAAAAAAAEAEESKPETETA 1156
                   ::|.|.|||.|||.|||:|||||||:||||||.|.|||.|||||||.||.:    |.|
Mosquito  1007 ADPSEKPNRFKIRKPWTTCLAENKKIWKEQAVRDAEARAAAAAAEAAAAAAAAAAEAN----EQA 1067

  Fly  1157 DGEQSEPAAEPAD 1169
            ..|:.|..|:.|:
Mosquito  1068 PAEEEEAKADAAE 1080

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	662..722	CDD:462497	56/59 (95%)
		PDEase_I	807..1027	CDD:459723	173/219 (79%)
LOC1279930	XP_061510049.1	None