Protein Alignment Pde1c and pde1a

DIOPT Version :10

• Sequence 1: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: NP_001096444.1
• Gene: pde1a / 100125056
• XenbaseID: XB-GENE-949176
• Length: 538
• Species: Xenopus tropicalis
• Alignment Length: 469
• Identity: 228/469 - (48%)
• Similarity: 320/469 - (68%)
• Gaps: 14/469 - (2%)

  Fly   662 RLADEDDELSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAGIFVDRMYRR 726
            ||.|.:||||::..|:||.|||:||||||||:|...:|:.:|||||||:.||::|||||:|||||
 Frog    73 RLLDTEDELSDIHTDSVPLEVRDWLASTFTRKMGMRKRRPEEKPKFRSIVHAVQAGIFVERMYRR 137

  Fly   727 VSSSALTAFPPDVVRLLKNLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEA 791
            .|:.|...:|..|:..:|::|.|.|:||.|.||:....:|::.||||.||...::|||....|.:
 Frog   138 SSNIAGLTYPSSVIASMKDVDRWAFNVFTLNEASGEHALKFMVYELFTRYDLTNRFKIPVSNLVS 202

  Fly   792 FLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTT 856
            |:..:|.||.:|:|||||.:||.||.||:||.:.:||:|:|||:|||.|.:.||.:||:||||||
 Frog   203 FVEALEVGYSKYKNPYHNLVHAADVTQTVHYIILHTGIMHWLTELEILAMIFAAAIHDFEHTGTT 267

  Fly   857 NNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDM 921
            ||||:.:.|:.|:|||||:||||||.||::|::::||.||..:||::::|:||.|||||||.|||
 Frog   268 NNFHIQTRSDVAILYNDRSVLENHHVSAAYRIMQDDEMNIFINLSKDDWRDLRTLVIEMVLSTDM 332

  Fly   922 TNHFQQMKAMRQLLTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEK 986
            :.||||:|.||..|...|. |||.|.:||:||..|||||||.|.:|.|||.||:||||||||.|.
 Frog   333 SGHFQQLKTMRSTLQQPEG-IDKAKAMSLILHAADISHPAKPWDMHLRWTNLLMEEFFRQGDKEA 396

  Fly   987 ELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLELILAPIAPMNKSKPATLVEHETTA 1051
            .|||||||||||.:|:||:|||.||||||||:..:::|..|.|:.|           |:|....:
 Frog   397 ALGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFTLLTDSTEKIVFP-----------LIEEAAKS 450

  Fly  1052 NSTTNSAIVIPNSGITPSMDKPRDHRTEAKTTAAECLARKSVTGTTASKFNIPKPWLTCLVENKR 1116
            :::........||.:....|.||  :...:|:..:..:....:..|....:..|..:..:.:||.
 Frog   451 DNSVFDKSSQNNSEVVRGTDTPR--KPSVRTSQMDGSSPSEYSLATVDLHHFKKNLVEIIQQNKE 513

  Fly  1117 IWKEQAVKDAEARA 1130
            .|||.|.::...::
 Frog   514 RWKELAAQERNLKS 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	662..722	CDD:462497	37/59 (63%)
		PDEase_I	807..1027	CDD:459723	136/219 (62%)
pde1a	NP_001096444.1	PDEase_I_N	73..133	CDD:462497	37/59 (63%)
		PDEase_I	218..443	CDD:459723	139/236 (59%)