Protein Alignment Pde1c and pde1b

DIOPT Version :10

• Sequence 1: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: XP_017946519.1
• Gene: pde1b / 100036722
• XenbaseID: XB-GENE-987197
• Length: 554
• Species: Xenopus tropicalis
• Alignment Length: 613
• Identity: 259/613 - (42%)
• Similarity: 353/613 - (57%)
• Gaps: 92/613 - (15%)

  Fly   565 PAPKLQPALETVRESVMEESPSKDPGDKGPPPPASTSTLTSQTTTSSSATAEPSAK--------- 620
            |.| |.|.        |.||||.|            ..|....|:.....:.||.|
 Frog    14 PLP-LHPG--------MMESPSVD------------KDLLEGCTSPFELKSAPSKKMWVKLRSLL 57

  Fly   621 ---AAESQAGSAGSSGSCSNPAAVHRQRRLR-TPTWARSMSTNKTR-LADEDDELSEVQPDAVPP 680
               ..:.:.|...         .|..::.|. |.:...::..::|| :.|.||||.|::.|:||.
 Frog    58 KYMVKQLENGEVN---------IVELKKNLEYTASLLEAVYIDETRQILDTDDELPEMRSDSVPS 113

  Fly   681 EVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAGIFVDRMYRRVSSSALTAFPPD----VVR 741
            |||:|||||||:|..::.|:|:|||:|||:.||::|||||:||:||    :.||..|:    ||.
 Frog   114 EVRDWLASTFTQQTRSTGRRSEEKPRFRSIVHAVQAGIFVERMFRR----SYTAVGPNYSAAVVN 174

  Fly   742 LLKNLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNP 806
            .||:||.|.||||.|...:....:|.:.:||.:|:....:|||....|.:||..:|.||.:|:||
 Frog   175 SLKHLDLWDFDVFVLNRVSEDHALKTIVFELLSRHNLNSRFKIPVAFLMSFLDSLESGYGKYKNP 239

  Fly   807 YHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLY 871
            |||.:||.||.||:|..|..||:::.|.::||.|.:.||.:||:|||||||:||:.:.|:.|:||
 Frog   240 YHNQIHAADVTQTVHCFLLRTGMVHCLNEIEILAIIFAAAIHDFEHTGTTNSFHIQTKSDCAILY 304

  Fly   872 NDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLT 936
            |||:||||||.||.:|::::||.||..:|:::||.|||.|||||||.|||:.||||:|.|:..|.
 Frog   305 NDRSVLENHHVSAVYRIMQDDEMNIFVNLTKDEFTELRSLVIEMVLATDMSCHFQQVKTMKTSLQ 369

  Fly   937 LQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNT 1001
             |..||||.|.|||:||..|||||.|||.||.|||..|:||||||||.|.|:||||||||||.:|
 Frog   370 -QLETIDKSKALSLLLHAADISHPTKQWKVHARWTKALMEEFFRQGDKEAEMGLPFSPLCDRKST 433

  Fly  1002 LVAESQICFIDFIVEPSMGVMSDMLELILAPIAPMNKSKPATLVEHETTANSTTNSAIVIPNSG- 1065
            |||:|||.||:|||:|:..|::|:.|..:.|           |||..:.:.||   |.|..:|.
 Frog   434 LVAQSQIGFIEFIVDPTFSVLTDVAEKTVLP-----------LVEERSKSKST---ASVNQSSSQ 484

  Fly  1066 -ITPSMDKPRDHRTEAKTTAAECLARKSVTGTTASKFNIPKPWLTCLVENKRIWKEQAVKDAEAR 1129
             ..||:|   || :|.....|:.   ||...|          |...:.|||:.|||:|   |...
 Frog   485 WRQPSID---DH-SEMGDINADI---KSFRTT----------WTKYIQENKQKWKERA---ASGI 529

  Fly  1130 ALATAAEEAAAAAAAEAEESKPETETAD 1157
            ...|:.:|   .:..|.:.|..|....|
 Frog   530 TNQTSVDE---LSPCEEQHSTEENGNLD 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	662..722	CDD:462497	36/60 (60%)
		PDEase_I	807..1027	CDD:459723	133/219 (61%)
pde1b	XP_017946519.1	PDEase_I_N	95..155	CDD:462497	35/59 (59%)
		PDEase_I	240..467	CDD:459723	136/238 (57%)