Protein Alignment Dlg5 and dlg5

DIOPT Version :10

• Sequence 1: NP_609505.1
• Gene: Dlg5 / 34573
• FlyBaseID: FBgn0032363
• Length: 1916
• Species: Drosophila melanogaster
• Sequence 2: XP_004916076.1
• Gene: dlg5 / 779611
• XenbaseID: XB-GENE-978275
• Length: 1971
• Species: Xenopus tropicalis
• Alignment Length: 2216
• Identity: 563/2216 - (25%)
• Similarity: 887/2216 - (40%)
• Gaps: 642/2216 - (28%)

  Fly     4 MASGDLS------LTSTSSQEEESSEYVGYDNTLRPPSNSSGSTTAANMSNNNGPSKGVSSGV-- 60
            :.:||.:      ||:..|..|.|........|.:|   ||...|||:....|...:.:.|.:
 Frog    93 LGTGDTAGSTYSVLTTMPSDSESSGSLSSIGTTNKP---SSPPPTAADSLQVNEKIETILSQLRQ 154

  Fly    61 ----------GVSGISGGN-----------GANYDILQAQYKSALLELNTLRHQHANTKRRCDEL 104
                      .::..|.|:           ..:|:.|:.|...|:.||..|:.|||...::|:|.
 Frog   155 VTRERDELRKRLALSSPGSTFDDCRSSPKLTPDYERLKVQCMKAMSELEALQSQHAKALKKCEEA 219

  Fly   105 ATELTLYQEHYVADRNKFTDMVEESARFKRLLLETQN-----QQSQQ------------------ 146
            |.|...|...:....:..|.:.|:|...:|...:.|.     |||.|
 Frog   220 AKEADFYHALHSRMLSDHTQLQEDSESMRRNHAQLQREFSHLQQSCQDLKHLHETDQLEMSELRR 284

  Fly   147 ------AQNGNSQV---------------------------PPVGSGN----------------- 161
                  .|||:|::                           ..|.|.|
 Frog   285 QQQLVVKQNGSSELINKLYNTALDKLEGVKKDYDSLRRQYNEKVSSHNLDLGRLEQSEEEKRSLQ 349

  Fly   162 ----------------PYYFGKTQGCDGSCSEKL-------AELKKERNMVAVEREKYKKSYIEL 203
                            .:.|..:.....|..::|       .||::|...:..|..::|...::.
 Frog   350 KQLEGLLKQRENAIHFQHQFSSSMRRYDSIQQELNKVTLQNKELQREMERLQAEATRFKTMQLKA 414

  Fly   204 EKDRNYYRERGDENQKLKVLLSQESKNVLSLTEELNQLLSEKDNVLQEHQKMSDDLVLANKEIER 268
            .|:...|:|..|                 |:..|...::||:|.|::|..||..:|.||...::.
 Frog   415 SKEAEKYKEERD-----------------SVFNEYRLIMSERDQVIKEMDKMQTELELAQGRLKN 462

  Fly   269 LKKDEQLARAEIKVL-QLANADLKKRD------------------------------------LL 296
            ...::::|..|::.| |..|:.|.:||                                    :.
 Frog   463 TSSEKRVASEEMEALRQELNSALVERDRSIFERNELLEKYCHEVKDKAEAQKELDQACKDIETVK 527

  Fly   297 KSRDSSWS-------------KEFPSGKELENS---------KELEKLRKSLEKALSEVERSSQD 339
            :.||.:..             :|:...:::::|         ||:|.|||..|....|::.::|:
 Frog   528 EERDVARKERTEAIIQRDHLLREYYQARQIQDSATLDMERANKEIEVLRKQYEAMSHELKEATQE 592

  Fly   340 AEEAKRVRDWAISQREKIVQERDSVKTLCDKMRHERDKAISDSLMAIRDSEKIKKQKDEAQKKID 404
            ||.||..||||..:|:|||.||:|::||||.:|.|||:|:|:...|:|:.:.::|||::|.:::.
 Frog   593 AEVAKCRRDWAFQERDKIVAERESIRTLCDNLRRERDRAVSELAEALRNLDDMRKQKNDASRELK 657

  Fly   405 LLKEQMEQQERQNLDSNASGSRRSFRPSSYEG---EDLLEVELSGYEHTSD--------LGIILD 458
            .|||:|:.|..:.     :..|:....||::.   .|.||.|....|...|        ||..:.
 Frog   658 ELKEKMDNQMEKE-----ARFRQLMAHSSHDSAIDTDSLEWETEVVEFERDREDMDLKALGFDVA 717

  Fly   459 DSNKRKLVCG--------VTSSSPACGKLKINDVICKVNNLDCQSLSKRMVLDEIRACAPRSLLL 515
            |.....|..|        |...|.|.|:|::||.:.|:|::|..:..::.:|..:.: ....:.:
 Frog   718 DGVNEPLFPGESCIFVTKVDKGSIADGRLRVNDCLLKINDVDLANKDRKQLLKAVLS-GGEVINM 781

  Fly   516 VSRTRHSKRHAYSVQLKTR---DRDCPHGLQLDMGVFIAKIEQNSLAFYEPELDVGDRVLSINNK 577
            |.|.|.|..:.....|...   .:|  .|:.|:.||.::.:...|.|..|..|..||||::||..
 Frog   782 VIRRRKSLGNRIITPLHIHLGSQKD--SGISLESGVLVSAVVPGSPAAKEGSLVAGDRVVTINGI 844

  Fly   578 SMDSVQSIEEVMQLMNDPRSDGLNLFALKYVQDQLPPGMT------------------------- 617
            |:|: :|:.|...|:.:.: :.|||..||.|    ||..:
 Frog   845 SLDN-KSVMECEALLRNCQ-ESLNLSLLKVV----PPNTSWSGQNLFENLKESCHVLSPNIHAQN 903

  Fly   618 ------TSSAQTDSID---------------------------SMQHVSSAGG----GGGSGPSS 645
                  .||.|||..:                           |...:||.||    |.|.....
 Frog   904 KRNLKNNSSTQTDIFNPDILECKKNMGDRTGSERALQLSCHSHSEHSLSSLGGEVFMGQGYDILD 968

  Fly   646 ATKHPSRFAEFFFRKLKFSKPGTPEDNFEQEHDDAIAALDSVLSENSSEKSKENLFNRKKRTKKE 710
            ...||..||:            |.|||               |.|.::.|
 Frog   969 DGGHPLGFAD------------TMEDN---------------LVETATGK--------------- 991

  Fly   711 KEASKSMGTWPRTNISHENPTGTMRGNEKKRALMSLF---------TAGPINVDKDDELMGEVGV 766
                :|.||||:..:|..:..|.....:|.|...|:|         |...|:.....:::|....
 Frog   992 ----RSSGTWPKVMVSPGHSQGEFTVFKKPRHRKSIFDPDTFKRPQTPPKISFLPPVQVLGHSPQ 1052

  Fly   767 PEKQPAALIQDQLP-PPLPPQMSKPLAHIRGSNGGAIK-THPNRNSNPVSSGVSALFPPGPPNGM 829
            |.|      .::.| ||.||:.|           .:|| .|.:::|:...|.|:|..||..|:..
 Frog  1053 PSK------TERPPTPPTPPKRS-----------DSIKFKHRHQSSSASDSTVTAGSPPTSPSPG 1100

  Fly   830 P---NTSYPTHPRHSLYGVTAEEINQKP----IQRAPLMGANARVKMPSQERYGTRPHS----NH 883
            |   .||:..|...::.....|:....|    |....:.|...|.:.|..:|  .||.|    .|
 Frog  1101 PLPAETSHKAHHSRAIGSCCREDGIDCPLTGCIGTGDVEGCLQRAEEPELKR--ARPRSAPALRH 1163

  Fly   884 RLSLNITPSGDFYQPKTSGQQAQQQVMNASSTSAGFGVGSGSMVGGTGPAAGEFPVRKQQVYDVF 948
            ||:..:.|.          ...|:..||:...              ..|......:|       |
 Frog  1164 RLAPVLIPH----------YALQKFSMNSEER--------------LSPELAHDWIR-------F 1197

  Fly   949 HPPPLPKNSS--GSNMFMPLHPTRGSHPPPVGQPPDVVSLKSQNSIESILSAKSPAISEYGMYAK 1011
            .|...|::|.  .::|:.|  ...|:.|..:                    |..||::
 Frog  1198 SPTRSPRHSDIFAASMYGP--GMSGTVPRSL--------------------APCPAVT------- 1233

  Fly  1012 RHVPQAVRHVPKYPSDSESIGSGVHGGYGGFLQSNHMPGNRHTQLFPTFGPGGRGNRRSSPLTLP 1076
                 ||...|.|.:                 .|:.:|.|                      ..|
 Frog  1234 -----AVLRNPIYTA-----------------WSHRVPSN----------------------NCP 1254

  Fly  1077 SPPPQQQLQQLPAATAPHDSVGIPTDL-DYHPHHHTQTNAMPHPHPHPHAPYLDYGHGLGIGPYM 1140
            |...|...|.|.::...|..:.:  || :.||:....|:....||
 Frog  1255 SSANQICQQHLHSSAQHHGRLSL--DLSNKHPNEFCDTSRSRVPH-------------------- 1297

  Fly  1141 GVGGGVSGVGGAIYEGGTFPRKKDNQRLRIPSNPSVASKSSSMVKNSSGSIDHHYVTSTGPVSGG 1205
                |.:.:..:...|.:     ..:|::|||.|.....|   |.:..||:.|...:|.
 Frog  1298 ----GSNSLPSSARLGSS-----RTERIKIPSTPRYPRSS---VGSDRGSLSHSECSSP------ 1344

  Fly  1206 SMSASSSDRAPMSLMSSSIHNSYGANIAGGNGTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGG 1270
              |.:|...:|::|.:||..:|.         :.||:             :.:|::.|..:.
 Frog  1345 --SLASPPHSPLNLETSSFASSQ---------SQSSV-------------ASLPRISVSTVP--- 1382

  Fly  1271 GGSGKRNSNVPADFLCPGDLRRVTIDKRDKSLGITIQCNNNGGGIFVSTVADKSTAMRAGLQVGD 1335
              .|:|..:.|    ...:.|.|.:.|..:.|||:|. ....||||||.|...|.|.:|||:.||
 Frog  1383 --IGERRKDRP----LVEEPRHVKVQKGSEPLGISIG-GGESGGIFVSKVTTGSIAQQAGLEYGD 1440

  Fly  1336 QLLEVCGINMRAATQEIAANVLRQCGDSFTMLVQYNPEKFPSIEYEGAHNLEPESPINHSGSPTP 1400
            ||||..|||:|.||::.|..::.|..|:.|:|.||||.....|....:..|:..:  .||   ||
 Frog  1441 QLLEFNGINLRNATEQQARLIIGQQCDTITILAQYNPNMCQHIHSRSSSRLDTST--THS---TP 1500

  Fly  1401 RNSPRPPARNSLFPLPMQPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATT 1465
            .:|                       |:..|.:|      |..|::..|.:  .:...||..:|.
 Frog  1501 HSS-----------------------GAATPDNH------SIIDTVSEQDE--GTMTPPSKESTP 1534

  Fly  1466 TTTTASATSTVYDEEPKPSLPPPPASVPAETLRYVTLHMDKSKNLGIKLFGGNKVGIYVHDV--- 1527
            :|:..|:..|..:...:.|           .||.|||.....| |||::.|||..||:|.|:
 Frog  1535 STSPCSSLRTNAEGIKRHS-----------ELRVVTLSKSPEK-LGIQICGGNLHGIFVLDIEEE 1587

  Fly  1528 -AVGSPSDHAGIRKGDQILEYNGVDLSGVTAEQAANEISKLTDTVTMLVQNKLHTLKQIKDEPGD 1591
             .||      |:.|||.:|||..||:...|||:|..|:.|..:.:.:.||.|:....::||.|||
 Frog  1588 NVVG------GLLKGDMVLEYGSVDMRNRTAEEAYLEMLKPAENIKVKVQQKIDEFNKLKDLPGD 1646

  Fly  1592 SFYIRVGFDRTGELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHRKECGIIPSQMKVE 1656
            .||||..:||..|| ..:|.|.||::||||:|:..||||.|.||:||....:.:.|.:||:..:|
 Frog  1647 GFYIRALYDRQAEL-PSELSFKKDDILYVDDTLPQGTFGTWMAWQLDENAQKLQRGQVPSKYMME 1710

  Fly  1657 EE----LRSGEVVDCDTGTARRGSTSARRSFFRRK-KNQRSSSRDSTEIASFSNTQLSFFPDLGL 1716
            :|    |...|..| :|..::..|.:||||||||| |::||.|||..::...........|.|
 Frog  1711 QEFSRRLSMSEGRD-ETMASKTLSAAARRSFFRRKNKHKRSGSRDGKDLQGLDTISTDSIPFL-- 1772

  Fly  1717 LNDDGGALSYQRVELLDSPIRRPVLIIGPLSECLMVRLTIDFSNLFKLCEVTAMDCSQEAMEEGL 1781
              |:..:|:||||:.:|....|||||:|||.:.:...|..:....|..|.:..|..||:|:|.|:
 Frog  1773 --DESVSLAYQRVQRVDCTSPRPVLILGPLVDAVKDMLVKESPGKFCRCPLEVMKASQQAIERGV 1835

  Fly  1782 KENIFVDYRRRGNKFECTTVEAISNACKNDRRHCILDVSISAVERLQRLQIYPIVLLLRFKSAKQ 1846
            |:.:|:||:||...|:.|||.:|....:.| .||:||::..|:|||..:.||||||.:|:||.||
 Frog  1836 KDCLFIDYKRRSGHFDVTTVASIKEITEKD-CHCLLDIAPHAIERLHSVHIYPIVLFIRYKSTKQ 1899

  Fly  1847 IRDIRD--FGTDKISAKAAKEMYERAMKLETDYKQYISAVIPGVSIKHMCTQIKDAVDKEQDKLL 1909
            |::.:|  |..||::.|.:||.:|.|.|:|.:|.:|.:|||.|.::..:|.||...||:||.|.|
 Frog  1900 IKEQKDPIFLRDKVTQKHSKEQFETAHKIEQEYSKYFTAVIQGGALFSICNQICSIVDQEQSKAL 1964

  Fly  1910 WVPVSS 1915
            |:|..|
 Frog  1965 WIPAGS 1970

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	COG1340	176..>416	CDD:440951	79/305 (26%)
		PDZ_canonical	441..516	CDD:467153	20/90 (22%)
		PDZ_canonical	540..609	CDD:483948	24/68 (35%)
		PDZ3_DLG5-like	1288..1370	CDD:467248	36/81 (44%)
		PDZ_canonical	1498..1576	CDD:483948	32/81 (40%)
		SH3_DLG5	1594..1657	CDD:212794	28/62 (45%)
		NK	<1773..1905	CDD:450170	59/133 (44%)
dlg5	XP_004916076.1	CARD	9..88	CDD:260018
		Takusan	129..213	CDD:461445	19/83 (23%)
		EnvC	197..>420	CDD:443969	37/222 (17%)
		Smc	<348..>731	CDD:440809	95/404 (24%)
		PDZ1_DLG5-like	692..786	CDD:467245	22/94 (23%)
		PDZ2_DLG5-like	798..874	CDD:467246	26/83 (31%)
		PDZ_canonical	1394..1475	CDD:483948	36/81 (44%)
		dbPDZ_assoc	1475..1554	CDD:465197	23/125 (18%)
		PDZ4_DLG5-like	1554..1631	CDD:467247	33/83 (40%)
		SH3_DLG5	1649..1711	CDD:212794	28/62 (45%)
		GuKc	1784..1960	CDD:214504	72/176 (41%)