Protein Alignment Dlg5 and dlg1b

DIOPT Version :10

• Sequence 1: NP_609505.1
• Gene: Dlg5 / 34573
• FlyBaseID: FBgn0032363
• Length: 1916
• Species: Drosophila melanogaster
• Sequence 2: XP_009295215.1
• Gene: dlg1b / 497648
• ZFINID: ZDB-GENE-050222-3
• Length: 966
• Species: Danio rerio
• Alignment Length: 1126
• Identity: 252/1126 - (22%)
• Similarity: 429/1126 - (38%)
• Gaps: 356/1126 - (31%)

  Fly   942 QQVYDVFHPPPLPKNSSGSNMFMPLHPTRGSH--------------PPPVGQPP----DVVSLKS 988
            |:|.|:|.          ||:|..|...:..:              ..|...||    |..|::|
Zfish    35 QRVIDIFQ----------SNLFQALIDIQEFYEVTLLDTERCGELVKVPDALPPVNLWDFSSIQS 89

  Fly   989 QNSIESILSAKSPAISEYGMYAKRHV---------------------PQAVRHVPKYPSDSESIG 1032
            .......|.:.|.:|.:|     ||.                     |:.|:...|..|..|:
Zfish    90 TTVTSDTLPSLSTSIEKY-----RHQDEDTGSPQEPSSPQFTDDTPGPELVQVAEKSLSQIEN-- 147

  Fly  1033 SGVHGGYGGFLQSNHMPGNRHTQLFPTF-GPGGRGNRRS--SPLT-LPSPPPQ-----QQLQQLP 1088
              ||    ||:..:|:...:...|...| ||.......|  ||.| |.:|.||     ||...:|
Zfish   148 --VH----GFVAHSHISPMKVESLECIFDGPSPVVKEESPPSPSTPLSNPYPQSPVSVQQTDAVP 206

  Fly  1089 AAT-----APHDSVGIPTDLDYHPHHHTQTNAMPHPHPHPHAPYLDYGHGLGIGPYMGVGG---- 1144
            .:|     .|..:|  ||:    |...:.:.:..:|     .|.:.....|...||  |.|
Zfish   207 PSTLIIPVIPISTV--PTE----PAVISPSTSQANP-----PPVVVNTESLDSAPY--VNGTEAD 258

  Fly  1145 ----------GVSGVGGAIYEGGTFPRKKDNQRLRIPSNPSV----------ASKSSSMVKNS-- 1187
                      |.||:|.:| .|||     ||.  .|..:||:          |::...:..|.
Zfish   259 FEYEEITLERGNSGLGFSI-AGGT-----DNP--HIGEDPSIFITKVIPGGAAAQDGRLRVNDVI 315

  Fly  1188 --SGSIDHHYVTSTGPV----SGGSM-------SASSSDRAPMSLMSSSIHNSYGANIAGGNGTG 1239
              ...:|...||.:..|    ..||:       ..|:|::    :|...:       |.|..|.|
Zfish   316 LRVNEVDVRDVTHSKAVEALKEAGSLVRLYVRRRKSASEK----VMEIKL-------IKGPKGLG 369

  Fly  1240 SSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRRVTIDKRDKSLGI 1304
            .||                           .||.|  |.::|.|
Zfish   370 FSI---------------------------AGGVG--NQHIPGD--------------------- 384

  Fly  1305 TIQCNNNGGGIFVSTVADKSTAMRAG-LQVGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLV 1368
                    ..|:|:.:.:...|.:.| ||:||:||.|....:...|.|.|...|:...|...:.|
Zfish   385 --------NSIYVTKIIEGGAAHKDGRLQIGDKLLAVNSSCLEEVTHEHAVTALKNTPDVVYLKV 441

  Fly  1369 QYNPEKF-------PSIEYEGAHNLEPESPINHSGSPTPRNSPRPPARNSLFPLPMQPQAPSTRP 1426
            ......|       |.|....:.::|     ||...|:..:.|.||..:..|
Zfish   442 AKPNSVFMNDSFAPPDITNSYSQHME-----NHISPPSYLSQPLPPVHSGRF------------- 488

  Fly  1427 GSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPKPSLPPPPAS 1491
               :|....::.|...|                                   .||
Zfish   489 ---SPTPKTTVGDDDVT-----------------------------------REP---------- 505

  Fly  1492 VPAETLRYVTLHMDKSKNLGIKLFGG-NKVGIYVHDVAVGSPSDHAG-IRKGDQILEYNGVDLSG 1554
                  |.|.||.. :..||..:.|| :..||::..:..|.|:|..| :||||:::..||:||.|
Zfish   506 ------RKVVLHRG-TTGLGFNIVGGEDGEGIFISFILAGGPADLCGELRKGDRLVSVNGIDLRG 563

  Fly  1555 VTAEQAANEISKLTDTVTMLVQ----------NKLHTLKQ-------------IKDEPGDSFYIR 1596
            .|.||||..:.....|||::.|          .|:|.|::             ::.....|.|:|
Zfish   564 ATHEQAAAALKNAGQTVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVR 628

  Fly  1597 VGFD----RTGELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHRKECGIIPSQMKVEE 1657
            ..||    :...|....|.|...::|:|.|.   .....|:|.::.|.|..:|.|:|||:.:||:
Zfish   629 ALFDYDKTKDSGLPSQGLNFKFGDILHVVNA---SDDEWWQARQVTAQGEVEEMGVIPSKRRVEK 690

  Fly  1658 ELRSG-EVVDCDTGTARRGSTSARR--SFFRRK----KNQRSSSRDSTEI-----ASFSNTQLSF 1710
            :.|:. :.|..::.:..:||.:.:|  :.|.||    ||:..|.::::::     ::.|:::.|:
Zfish   691 KERARLKTVKFNSKSREKGSLNDKRKKNLFSRKFTFYKNKDVSEQETSDVEQHVTSNASDSESSY 755

  Fly  1711 FPDLGLLNDDGGALSYQRVELLDSPIRRPVLIIGPLSECLMVRLTIDFSNLFKLC---------- 1765
                  ...:...|||:.|...:....|||:|:||:.:.:...|..:|.:.|..|
Zfish   756 ------RGQEEYVLSYEPVSQQEVNYSRPVIILGPMKDRVNDDLISEFPDKFGSCVPHTTRPKRD 814

  Fly  1766 -EVTAMD----CSQEAMEEGLKENIFVDYRRRGNKFECTTVEAISNACKNDRRHCILDVSISAVE 1825
             ||...|    .|:|.||..::|:.|::..:..:....|:|:::....:.. :|||||||.:|::
Zfish   815 YEVDGRDYHFVVSREQMERDIQEHKFIEAGQYNSHLYGTSVQSVREVAEKG-KHCILDVSGNAIK 878

  Fly  1826 RLQRLQIYPIVLLLRFKSAKQIRDIRDFGTDKISAKAAKEMYERAMKLETDYKQYISAVIPGVSI 1890
            |||...:|||.:.::.||.:.|.::    ..:::.:..::.|:||||||.::.::.:|::.|.::
Zfish   879 RLQVAMLYPIGIFIKPKSVENIMEM----NKRLTEEQGRKTYDRAMKLEQEFMEHFTAIVQGDTL 939

  Fly  1891 KHMCTQIKDAVDKEQDKLLWV 1911
            :.:..|:|..::::....:||
Zfish   940 EEIYDQVKQIIEEQSGPYIWV 960

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	COG1340	176..>416	CDD:440951
		PDZ_canonical	441..516	CDD:467153
		PDZ_canonical	540..609	CDD:483948
		PDZ3_DLG5-like	1288..1370	CDD:467248	17/82 (21%)
		PDZ_canonical	1498..1576	CDD:483948	31/79 (39%)
		SH3_DLG5	1594..1657	CDD:212794	20/66 (30%)
		NK	<1773..1905	CDD:450170	36/131 (27%)
dlg1b	XP_009295215.1	L27_1	7..64	CDD:462665	8/38 (21%)
		MAGUK_N_PEST	106..262	CDD:431391	41/181 (23%)
		PDZ1_Dlg1-2-4-like	261..349	CDD:467206	21/95 (22%)
		PDZ2_Dlg1-2-4-like	358..442	CDD:467207	28/148 (19%)
		PDZ_assoc	443..506	CDD:463164	16/134 (12%)
		PDZ3_Dlg1-2-4-like	504..594	CDD:467257	34/106 (32%)
		SH3_DLG1	623..689	CDD:212964	20/68 (29%)
		Guanylate_kin	775..953	CDD:395500	49/182 (27%)