Protein Alignment Dlg5 and dlg2

DIOPT Version :10

• Sequence 1: NP_609505.1
• Gene: Dlg5 / 34573
• FlyBaseID: FBgn0032363
• Length: 1916
• Species: Drosophila melanogaster
• Sequence 2: XP_009303687.1
• Gene: dlg2 / 497638
• ZFINID: ZDB-GENE-050221-3
• Length: 1031
• Species: Danio rerio
• Alignment Length: 1102
• Identity: 259/1102 - (23%)
• Similarity: 424/1102 - (38%)
• Gaps: 323/1102 - (29%)

  Fly   968 PTRGSHPPPVGQPPDVVSLKSQNSIESILSAKSPAI----SEYGMYAKRHVPQAVRHVPKYPSD- 1027
            ||.|  |.|...||:   ||..:.:|  |:.|.||:    :|| .|.....|......|:..::
Zfish    91 PTEG--PQPASTPPE---LKEDSRME--LTVKEPAVGCANTEY-RYQDDDSPPPEHSFPRLTNEV 147

  Fly  1028 --------SESIGSGVHGGYGGFLQSNHM----PG--NRHTQLFPTFGPGGRGNRRSSPLTLPSP 1078
                    ||...|.:...: |::..:|:    |.  .|....:|       |...::.|..|:|
Zfish   148 RAPELVHVSEKNLSEIENVH-GYVSHSHISPLKPALVTRFDLTYP-------GVTAANYLASPAP 204

  Fly  1079 --PPQQQLQQLPAATAPHDSVGIPTDLDYHPHHHTQTNAMPHPHPHPHAPYLDYGH-GLGI---- 1136
              .....|:.:|....        |:::|.....|                |:.|: |||.
Zfish   205 IIVNTDTLESVPYVNG--------TEIEYEFEEIT----------------LERGNSGLGFSIAG 245

  Fly  1137 ---GPYMGVGGGVSGV----GGAIYEGGTFPRKKDNQRLRI--------PSNPSVASKSSSM-VK 1185
               .|::|...|:...    |||..|.|         |||:        .|:.|..|.|.:: ..
Zfish   246 GTDNPHIGDDPGIFITKIIPGGAAAEDG---------RLRVNDCILRVNESDVSEVSHSKAVEAL 301

  Fly  1186 NSSGSIDHHYVTSTGPVSGGSMSASSSDRAPMSLMSSSIHNSYGANIAGGNGTGSSIGVGGGGGG 1250
            .::|||...||..               |.||....:.|     ..|.|..|.|.||
Zfish   302 KAAGSIVRLYVRR---------------RRPMLETVTEI-----KLIKGPKGLGFSI-------- 338

  Fly  1251 GSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRRVTIDKRDKSLGITIQCNNNGGGI 1315
                               .||.|  |.::|.|                             ..|
Zfish   339 -------------------AGGVG--NQHIPGD-----------------------------NSI 353

  Fly  1316 FVSTVADKSTAMRAG-LQVGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLVQYNPEKFPSIE 1379
            :|:.:.|...|.:.| |||||:||.|....:...|.|.|..:|:...|     |.|.....|:..
Zfish   354 YVTKIIDGGAAQKDGRLQVGDRLLMVNNYTLEEVTHEEAVAILKNTSD-----VVYLKVGKPTSV 413

  Fly  1380 YEGAHNLEPESP--INHSGSPTPRNSPRPPARNSLFPLPMQPQAPSTRPGSRAPLSHQSIKDQSF 1442
            |..    :|..|  |.||.||...|....|..|.  .|..:...|...||..:||....:.::..
Zfish   414 YLS----DPYGPPDITHSFSPAMENHISSPGNNG--TLEYKSSLPPISPGRYSPLPKHLLGEEDI 472

  Fly  1443 T-------------DSLE-NQSDISSSQDMPSSAATTTTTTAS--------ATSTVYDEEPKPSL 1485
            .             |.:| ::.|....|..|.....:|....|        .:...:|:.|..|:
Zfish   473 NRLDGFSFLRNPSLDEMEGHRFDSQHFQLRPPEPVYSTVNKLSDRAPSPRLYSPVEFDKSPMHSI 537

  Fly  1486 PP---------PPASVPAETLRYVTLHMDKSKNLGIKLFGG-NKVGIYVHDVAVGSPSDHAG-IR 1539
            |.         |.:.:..|. |.:.||.. |..||..:.|| :..||:|..:..|.|:|.:| :|
Zfish   538 PHFPHYHVGLLPDSEITREP-RKIVLHKG-STGLGFNIVGGEDGEGIFVSFILAGGPADLSGELR 600

  Fly  1540 KGDQILEYNGVDLSGVTAEQAANEISKLTDTVTMLVQ-------------------------NKL 1579
            :|||||..||:||.|.|.||||..:.....|||::.|                         .|:
Zfish   601 RGDQILSVNGIDLRGATHEQAAAALKGAGQTVTIIAQYRPEELALCSPRRAPPPTAEYGRFEAKI 665

  Fly  1580 HTLKQ-------------IKDEPGDSFYIRVGFD----RTGELNEDDLRFVKDEVLYVDNTVFNG 1627
            |.|::             ::.....|.|:|..||    :...|....|.|...::|:|.|.   .
Zfish   666 HDLREQMMNHSMSSGSGSLRTNQKRSLYVRALFDYERAKDSGLPSQGLSFRYGDILHVINA---S 727

  Fly  1628 TFGLWRAWKLDAMGHRKECGIIPSQMKVEEELRSG-EVVDCDTGTARRGSTSARRSF-------- 1683
            ....|:|.::...|..:|.|:|||:.:||.:.|:. :.|..:   |:.||..::.||
Zfish   728 DDEWWQARRVTPEGDSEEMGVIPSKRRVERKERARLKTVKFN---AKPGSLDSKGSFSEKRRKNF 789

  Fly  1684 -FRRK----KNQRSSSRDSTEIASFSNTQLSFFPDLGLLNDDGGALSYQRVELLDSPIRRPVLII 1743
             |.||    ||:.:..:|.:: :..|..:|              .|||:.|...:....|||:|:
Zfish   790 IFSRKFPFYKNKDADEQDGSD-SERSQEEL--------------ILSYEPVIRQEINYARPVIIL 839

  Fly  1744 GPLSECLMVRLTIDFSNLFKLC-------------------EVTAMD----CSQEAMEEGLKENI 1785
            ||:.:.:...|..:|.:.|..|                   ||...|    .|:|.||:.::|:.
Zfish   840 GPMKDRINDDLISEFPDKFGSCVPPANSSDQEDTTRPKRDYEVDGRDYHFMASREQMEKDIQEHK 904

  Fly  1786 FVDYRRRGNKFECTTVEAISNACKNDRRHCILDVSISAVERLQRLQIYPIVLLLRFKSAKQIRDI 1850
            |::..:..:....|:|:::....:.. :|||||||.:|::|||..|:|||.:.::.:|.:.:.::
Zfish   905 FIEAGQYNDNLYGTSVQSVKYVAERG-KHCILDVSGNAIKRLQVAQLYPIAIFIKPRSIESLMEM 968

  Fly  1851 RDFGTDKISAKAAKEMYERAMKLETDYKQYISAVIPGVSIKHMCTQIKDAVDKEQDKLLWVP 1912
                ..:::.:.||:.|:||||||.::.:|.:|::.|.:::.:..|.|..::::....:|:|
Zfish   969 ----NKRLTEEQAKKTYDRAMKLEQEFGEYFTALVQGDTLEDIYNQCKMVIEEQSGPYIWIP 1026

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	COG1340	176..>416	CDD:440951
		PDZ_canonical	441..516	CDD:467153
		PDZ_canonical	540..609	CDD:483948
		PDZ3_DLG5-like	1288..1370	CDD:467248	19/82 (23%)
		PDZ_canonical	1498..1576	CDD:483948	34/79 (43%)
		SH3_DLG5	1594..1657	CDD:212794	19/66 (29%)
		NK	<1773..1905	CDD:450170	38/131 (29%)
dlg2	XP_009303687.1	L27_1	7..64	CDD:462665
		MAGUK_N_PEST	126..228	CDD:431391	20/118 (17%)
		PDZ1_Dlg1-2-4-like	227..315	CDD:467206	26/127 (20%)
		PDZ2_Dlg1-2-4-like	324..408	CDD:467207	33/151 (22%)
		PDZ_assoc	409..474	CDD:463164	18/70 (26%)
		PDZ3_Dlg1-2-4-like	556..642	CDD:467257	36/87 (41%)
		SH3_DLG2	687..760	CDD:212965	21/75 (28%)
		Guanylate_kin	832..1018	CDD:395500	51/190 (27%)