DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dlg5 and Dlg4

DIOPT Version :10

Sequence 1:NP_609505.1 Gene:Dlg5 / 34573 FlyBaseID:FBgn0032363 Length:1916 Species:Drosophila melanogaster
Sequence 2:NP_062567.1 Gene:Dlg4 / 29495 RGDID:68424 Length:724 Species:Rattus norvegicus


Alignment Length:784 Identity:182/784 - (23%)
Similarity:306/784 - (39%) Gaps:240/784 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  1234 GGNGTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGS--GKRNSNVPADFLCPGDLRRVT-- 1294
            |.:|.|.||    .||..:......|.:.:..:..||..:  |:...|....|:...|:|.||  
  Rat    71 GNSGLGFSI----AGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHS 131

  Fly  1295 -------------------------------IDKRDKSLGITIQCNNNGG----------GIFVS 1318
                                           :.|..|.||.:|.    ||          .|:|:
  Rat   132 AAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIA----GGVGNQHIPGDNSIYVT 192

  Fly  1319 TVADKSTAMRAG-LQVGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLV----------QYNP 1372
            .:.:...|.:.| ||:||::|.|..:.:.....|.|...|:...|...:.|          .|.|
  Rat   193 KIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAP 257

  Fly  1373 EKFPSIEYEGAHNLEPESPINHS---GSPTPRNSPRPPARNSLFPLPMQPQAPSTRPGSRAPLSH 1434
               |.|....:.:|:.|  |:||   |:.              :|..|.|    |.|...:|:: 
  Rat   258 ---PDITTSYSQHLDNE--ISHSSYLGTD--------------YPTAMTP----TSPRRYSPVA- 298

  Fly  1435 QSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPKPSLPPPPASVPAETLRY 1499
                           .|:...:|:|                   .||                |.
  Rat   299 ---------------KDLLGEEDIP-------------------REP----------------RR 313

  Fly  1500 VTLHMDKSKNLGIKLFGG-NKVGIYVHDVAVGSPSDHAG-IRKGDQILEYNGVDLSGVTAEQAAN 1562
            :.:|.. |..||..:.|| :..||::..:..|.|:|.:| :|||||||..|||||...:.||||.
  Rat   314 IVIHRG-STGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 377

  Fly  1563 EISKLTDTVTMLVQ----------NKLHTLKQ-------------IKDEPGDSFYIRV--GFDRT 1602
            .:.....|||::.|          .|:|.|::             ::..|...||||.  .:|:|
  Rat   378 ALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKT 442

  Fly  1603 ---GELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHRKECGIIPSQMKVEEELRSGEV 1664
               |.|:: .|.|...:||:|   :..|....|:|.::.:.....:.|.|||:.:||        
  Rat   443 KDCGFLSQ-ALSFRFGDVLHV---IDAGDEEWWQARRVHSDSETDDIGFIPSKRRVE-------- 495

  Fly  1665 VDCDTGTARRGSTSARRSFFRRK-KNQRSSSRDSTEIASFSNTQLSFFPDLGLLNDDGGALSYQR 1728
                           ||.:.|.| |:..|||                    |....:...|||:.
  Rat   496 ---------------RREWSRLKAKDWGSSS--------------------GSQGREDSVLSYET 525

  Fly  1729 VELLDSPIRRPVLIIGPLSECLMVRLTIDFSNLFKLC-----------EVTAMD----CSQEAME 1778
            |..::....||::|:||..:.....|..:|.:.|..|           |:...|    .|:|.||
  Rat   526 VTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKME 590

  Fly  1779 EGLKENIFVDYRRRGNKFECTTVEAISNACKNDRRHCILDVSISAVERLQRLQIYPIVLLLRFKS 1843
            :.::.:.|::..:..:....|:|:::....:.. :|||||||.:||.|||...::||.:.:|.:|
  Rat   591 KDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQG-KHCILDVSANAVRRLQAAHLHPIAIFIRPRS 654

  Fly  1844 AKQIRDIRDFGTDKISAKAAKEMYERAMKLETDYKQYISAVIPGVSIKHMCTQIKDAVDKEQDKL 1908
            .:.:.:|    ..:|:.:.|::.::||.|||.::.:..||::.|.|.:.:..::|..::......
  Rat   655 LENVLEI----NKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPY 715

  Fly  1909 LWVP 1912
            :|||
  Rat   716 IWVP 719

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dlg5NP_609505.1 COG1340 176..>416 CDD:440951
PDZ_canonical 441..516 CDD:467153
PDZ_canonical 540..609 CDD:483948
PDZ3_DLG5-like 1288..1370 CDD:467248 26/135 (19%)
PDZ_canonical 1498..1576 CDD:483948 32/79 (41%)
SH3_DLG5 1594..1657 CDD:212794 20/67 (30%)
NK <1773..1905 CDD:450170 36/131 (27%)
Dlg4NP_062567.1 MAGUK_N_PEST 11..64 CDD:431391
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 15..35
PDZ1_Dlg1-2-4-like 63..151 CDD:467206 17/83 (20%)
PDZ2_Dlg1-2-4-like 160..244 CDD:467207 21/87 (24%)
PDZ_assoc 245..312 CDD:463164 21/140 (15%)
PDZ3_Dlg1-2-4-like 310..400 CDD:467257 35/106 (33%)
SH3_DLG4 430..495 CDD:212963 20/68 (29%)
Guanylate_kin 533..711 CDD:395500 47/182 (26%)
Blue background indicates that the domain is not in the aligned region.

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