Protein Alignment Dlg5 and DLG1

DIOPT Version :10

• Sequence 1: NP_609505.1
• Gene: Dlg5 / 34573
• FlyBaseID: FBgn0032363
• Length: 1916
• Species: Drosophila melanogaster
• Sequence 2: NP_004078.2
• Gene: DLG1 / 1739
• HGNCID: 2900
• Length: 926
• Species: Homo sapiens
• Alignment Length: 1133
• Identity: 257/1133 - (22%)
• Similarity: 419/1133 - (36%)
• Gaps: 371/1133 - (32%)

  Fly   938 PVRKQQVYDVFH-----PPPLPK--------------NSSGSNMFMPL-------------HP-- 968
            |||||......|     ...|.:              |...||:|..|             :|
Human     2 PVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKC 66

  Fly   969 -TRGSHPPPVGQPP---DVVSLKSQN-SIESILSAKSPAISEYGMY-----AKRHV-PQAVRHV- 1021
             .|.....|: ||.   ::.||.|.. :.|::.|:.||::.:|...     .:.|: ||....|
Human    67 IDRSKPSEPI-QPVNTWEISSLPSSTVTSETLPSSLSPSVEKYRYQDEDTPPQEHISPQITNEVI 130

  Fly  1022 -PKYPSDSESIGSGVHGGYGGFLQSNHMPGNRHTQLFPTFGPGGRGNRRSSPLTLPSPP------ 1079
             |:....||...|.:...: ||:..:|:...:.|:                 ..|||||
Human   131 GPELVHVSEKNLSEIENVH-GFVSHSHISPIKPTE-----------------AVLPSPPTVPVIP 177

  Fly  1080 ----PQQQ---LQQLPAATAP-----HDSVGIP-----TDLDYHPHHHTQTNAMPHPHPHPHAPY 1127
                |.:.   |..:|.|..|     .||:..|     ||.||.....|
Human   178 VLPVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEIT---------------- 226

  Fly  1128 LDYGH-GLGIGPYMGVGGGVSG---------------VGGAIYEGGTFPRKKDNQRLRIPSNPSV 1176
            |:.|: |||    ..:.||...               .|||..:.|         |||:  |..:
Human   227 LERGNSGLG----FSIAGGTDNPHIGDDSSIFITKIITGGAAAQDG---------RLRV--NDCI 276

  Fly  1177 A------------SKSSSMVKNSSGSIDHHYVTSTGPVSGGSMSASSSDRAPMSLMSSSIHNSYG 1229
            .            ||:...:| .:|||...||....|||...|....
Human   277 LRVNEVDVRDVTHSKAVEALK-EAGSIVRLYVKRRKPVSEKIMEIKL------------------ 322

  Fly  1230 ANIAGGNGTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRRVT 1294
              |.|..|.|.||                           .||.|  |.::|.|
Human   323 --IKGPKGLGFSI---------------------------AGGVG--NQHIPGD----------- 345

  Fly  1295 IDKRDKSLGITIQCNNNGGGIFVSTVADKSTAMRAG-LQVGDQLLEVCGINMRAATQEIAANVLR 1358
                              ..|:|:.:.:...|.:.| ||:||:||.|..:.:...|.|.|...|:
Human   346 ------------------NSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALK 392

  Fly  1359 QCGDSFTMLVQYNPEKFPSIEYEGAHNLEPESPINHSGSPTP--RNSPRPPARNSLFPLPMQPQA 1421
            ...|...:.|                 .:|.|...:.|...|  .||...|..|.:.|.....|.
Human   393 NTSDFVYLKV-----------------AKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQT 440

  Fly  1422 PSTRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPKPSLP 1486
            |:: |...:|:|...:.|...|                                   .||
Human   441 PAS-PARYSPVSKAVLGDDEIT-----------------------------------REP----- 464

  Fly  1487 PPPASVPAETLRYVTLHMDKSKNLGIKLFGG-NKVGIYVHDVAVGSPSDHAG-IRKGDQILEYNG 1549
                       |.|.||.. |..||..:.|| :..||::..:..|.|:|.:| :||||:|:..|.
Human   465 -----------RKVVLHRG-STGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNS 517

  Fly  1550 VDLSGVTAEQAANEISKLTDTVTMLVQ----------NKLHTLKQ-------------IKDEPGD 1591
            |||...:.||||..:......||::.|          .|:|.|::             ::.....
Human   518 VDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKR 582

  Fly  1592 SFYIRVGFD----RTGELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHRKECGIIPSQ 1652
            |.|:|..||    :...|....|.|...::|:|.|.   .....|:|.::...|...|.|:|||:
Human   583 SLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINA---SDDEWWQARQVTPDGESDEVGVIPSK 644

  Fly  1653 MKVEEELRSG-EVVDCDTGTARRGST---SARRSFFRRK----KN-----QRSSSRDSTEIASFS 1704
            .:||::.|:. :.|..::.|..:|.:   ..:::.|.||    ||     |.:|..|....::.|
Human   645 RRVEKKERARLKTVKFNSKTRDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNAS 709

  Fly  1705 NTQLSFFPDLGLLNDDGGALSYQRVELLDSPIRRPVLIIGPLSECLMVRLTIDFSNLFKLC---- 1765
            :::.|:      ...:...|||:.|...:....|||:|:||:.:.:...|..:|.:.|..|
Human   710 DSESSY------RGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHT 768

  Fly  1766 -------EVTAMD----CSQEAMEEGLKENIFVDYRRRGNKFECTTVEAISNACKNDRRHCILDV 1819
                   ||...|    .|:|.||:.::|:.|::..:..|....|:|:::....:.. :||||||
Human   769 TRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKG-KHCILDV 832

  Fly  1820 SISAVERLQRLQIYPIVLLLRFKSAKQIRDIRDFGTDKISAKAAKEMYERAMKLETDYKQYISAV 1884
            |.:|::|||..|:|||.:.::.||.:.|.::    ..:::.:.|::.:|||||||.::.::.:|:
Human   833 SGNAIKRLQIAQLYPISIFIKPKSMENIMEM----NKRLTEEQARKTFERAMKLEQEFTEHFTAI 893

  Fly  1885 IPGVSIKHMCTQIKDAVDKEQDKLLWVP 1912
            :.|.:::.:..|:|..::::....:|||
Human   894 VQGDTLEDIYNQVKQIIEEQSGSYIWVP 921

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	COG1340	176..>416	CDD:440951
		PDZ_canonical	441..516	CDD:467153
		PDZ_canonical	540..609	CDD:483948
		PDZ3_DLG5-like	1288..1370	CDD:467248	17/82 (21%)
		PDZ_canonical	1498..1576	CDD:483948	30/79 (38%)
		SH3_DLG5	1594..1657	CDD:212794	19/66 (29%)
		NK	<1773..1905	CDD:450170	39/131 (30%)
DLG1	NP_004078.2	L27_1	6..64	CDD:462665	8/57 (14%)
		MAGUK_N_PEST	107..223	CDD:431391	30/133 (23%)
		PDZ1_Dlg1-2-4-like	222..310	CDD:467206	24/119 (20%)
		PDZ2_Dlg1-2-4-like	319..403	CDD:467207	29/178 (16%)
		PDZ_assoc	404..465	CDD:463164	18/112 (16%)
		PDZ3_Dlg1-2-4-like	463..553	CDD:467257	33/106 (31%)
		SH3_DLG1	582..648	CDD:212964	19/68 (28%)
		Guanylate_kin	735..913	CDD:395500	52/182 (29%)