Protein Alignment Dlg5 and zoo-1

DIOPT Version :10

• Sequence 1: NP_609505.1
• Gene: Dlg5 / 34573
• FlyBaseID: FBgn0032363
• Length: 1916
• Species: Drosophila melanogaster
• Sequence 2: NP_001252376.1
• Gene: zoo-1 / 173316
• WormBaseID: WBGene00013683
• Length: 1163
• Species: Caenorhabditis elegans
• Alignment Length: 805
• Identity: 187/805 - (23%)
• Similarity: 323/805 - (40%)
• Gaps: 179/805 - (22%)

  Fly  1178 SKSSSMVKNSSGSIDHHYVTSTGPVSGGSMSASSSDRAPMSLMSSSIHNSYGANIAGGNGTGSSI 1242
            |:..|..|.|..|..........||........:.......|:|.|:|.:  ||:      |..|
 Worm     2 SEDPSWYKTSMSSTSSCIEEEHEPVDQDEEEMYNPSGCTWQLLSVSLHRA--ANL------GFGI 58

  Fly  1243 GVGGGGGGGSGRGSP----------------------MPQVHVEVLSHGGGGSGKRNSNVPADFL 1285
            .:.|      ||.:|                      :.||:..:||...........:...|.:
 Worm    59 AISG------GRDNPHFTSGDPVVVISDVVPNGPAWGLLQVNDRILSANQVSFENIEYSSAVDII 117

  Fly  1286 CPGD------LRRVTI----------------DKRDKSLGITIQCNNNGGGIFVSTVADKSTAMR 1328
            ...|      .|||.:                .::....||.:.|.     .::..:.:...|.:
 Worm   118 KNKDHIDMIVKRRVAVPMLEYEQRTLKFTLSKSRKKDDFGIVVGCK-----FYIKEIRNPKLAEK 177

  Fly  1329 -AGLQVGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLVQYN----PEKFPS--IEYEGAHNL 1386
             .||:.||.:|.:.|.::..|:.|.....|.:..|...:::|.:    ..::||  ..||...::
 Worm   178 DPGLKEGDSVLRINGQSLEGASLEEVNKWLERSRDKLCLVIQRDVRRGTSRWPSQNTVYERVGSV 242

  Fly  1387 EPESPINHSGSPTPRNSPRPPARNSLFPLPMQPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQSD 1451
                      :.|||:||.          ||.|..|.|:..     ||:      :.:|..::||
 Worm   243 ----------AATPRHSPS----------PMLPHMPITQRN-----SHE------YVNSPRHRSD 276

  Fly  1452 ISSSQDMPSSA-ATTTTTTASATSTVYDEEPKPSLPPPPASVPAETLRYVTLHMDKSKNLGIKLF 1515
            .|..:.:.|.| :..:.....|:|.:..::.......|..|:.|..:..: :......::|:::.
 Worm   277 GSVERRVSSPANSQLSNFNGMASSQITTQDYDCYTRQPSRSIDANGVANI-MFRKVGGSVGVRVI 340

  Fly  1516 GGNKVGIYVHDVAVGSPSDHAGIRKGDQILEYNGVDLSGVTAEQAANEISKLTDTVTMLVQNKLH 1580
            |||:|||:|..||..||:...|:..||:|||.||.::.|||.|.|...:..|.|.|::.:::...
 Worm   341 GGNEVGIFVSAVAADSPASLHGVSCGDRILEVNGRNMRGVTRESAVQLLLGLDDRVSLRLEHARQ 405

  Fly  1581 TLKQIK-DEPGDSFYIRVGFDRTG---------ELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAW 1635
            ..:.:: ::.||:||||..|.|..         .:||.|       :.:|.:|:|.||.|||:|.
 Worm   406 DFEHVRANQLGDNFYIRSHFSREKRDKASPLELSINEGD-------IFHVTDTLFGGTVGLWQAA 463

  Fly  1636 KLDAMGHRK---ECGIIPSQMKVEEELRSGEV-VDCDTGTARRGSTSARRSF-FRRKKN-QRSSS 1694
            ::.:....|   ..|:||:|...|:..:...| |:.....:....|..||.| .||.|: .::..
 Worm   464 RVYSSSENKGEPVKGVIPNQATAEQIAKEWRVYVEAKQAKSGGSGTLLRRKFESRRTKSLPKNMI 528

  Fly  1695 RDSTEIASFSNTQLSFFPDLGLLNDDGGALSYQRVELLDSPIRRPVLIIGPLSECLMVRLTIDFS 1759
            .|.||:    |..|.               :|:||.|......|||::.|||::....:|...||
 Worm   529 CDPTEL----NLPLP---------------AYERVALNTPSFHRPVVLFGPLADIARHQLLTQFS 574

  Fly  1760 NLFKLCEVTAMDCSQEAMEEGLKENIFVDYRRRGNKFECTTVEAISNACKNDRRHCILDVSISAV 1824
            ..|                 |..|:       .|.....::|:.:..:.|    ||:||:||.:|
 Worm   575 ARF-----------------GSPES-------DGGVIRLSSVDHVIASMK----HCVLDISIESV 611

  Fly  1825 ERLQRLQIYPIVLLLRFKSAKQIRDIRDFGTDKISAK--AAKEMYERAMKLETDYKQYISAVIPG 1887
            ||||..|..|||:.|......:||:||    .|.:|.  :::::.|...:::..:...:||.|..
 Worm   612 ERLQLAQYAPIVVFLDVDGRSKIREIR----KKCNAPHLSSRKLAENGNQIKKHHSHLLSATIDA 672

  Fly  1888 VSIKHMCTQIKDAVDKEQDKLLWVP 1912
            .........:::.:...|.:.||:|
 Worm   673 THETGWFDALRELIGHLQQRRLWMP 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	COG1340	176..>416	CDD:440951
		PDZ_canonical	441..516	CDD:467153
		PDZ_canonical	540..609	CDD:483948
		PDZ3_DLG5-like	1288..1370	CDD:467248	18/104 (17%)
		PDZ_canonical	1498..1576	CDD:483948	28/77 (36%)
		SH3_DLG5	1594..1657	CDD:212794	22/74 (30%)
		NK	<1773..1905	CDD:450170	31/133 (23%)
zoo-1	NP_001252376.1	PDZ1_ZO1-like	45..130	CDD:467209	17/98 (17%)
		PDZ2_ZO1-like_ds	143..221	CDD:467210	15/82 (18%)
		PDZ3_ZO1-like_domain	325..402	CDD:467211	28/77 (36%)
		SH3_ZO	420..487	CDD:212793	22/73 (30%)
		NK	539..690	CDD:450170	45/197 (23%)
		ZU5	1033..1133	CDD:459941