Protein Alignment Dlg5 and Dlg1

DIOPT Version :10

• Sequence 1: NP_609505.1
• Gene: Dlg5 / 34573
• FlyBaseID: FBgn0032363
• Length: 1916
• Species: Drosophila melanogaster
• Sequence 2: XP_006521824.1
• Gene: Dlg1 / 13383
• MGIID: 107231
• Length: 939
• Species: Mus musculus
• Alignment Length: 1134
• Identity: 259/1134 - (22%)
• Similarity: 420/1134 - (37%)
• Gaps: 360/1134 - (31%)

  Fly   938 PVRKQQVYDVFH-----PPPLPK--------------NSSGSNMFMPL-------------HPTR 970
            |||||......|     ...|.:              |...||:|..|             :|..
Mouse     2 PVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKC 66

  Fly   971 GSHP---PPVGQPP---DVVSLKSQN-SIESILSAKSPAISEY-----GMYAKRHV-PQAVRHV- 1021
            ..|.   .|| ||.   ::.||.|.. :.|::..:.||.:.:|     .:....|: ||....|
Mouse    67 VDHSKQCEPV-QPVTTWEIASLPSTAVTSETLPGSLSPPVEKYRYQDEEVLPPEHISPQVTNEVL 130

  Fly  1022 -PKYPSDSESIGSGVHGGYGGFLQSNHMPGNRHTQLFPTFGPGGRGNRRSSPLTLPSPPPQQQLQ 1085
             |:....||...|.:...: ||:..:|:...:.|:..|...|       ..|:|...|.|.:...
Mouse   131 GPELVHVSEKNLSEIENVH-GFVSHSHISPIKPTEAVPPSSP-------IVPVTPALPVPAESTV 187

  Fly  1086 QLPAATAPH--------DSVGIP-----TDLDYHPHHHTQTNAMPHPHPHPHAPYLDYGH-GLGI 1136
            .||:|...:        ||:..|     ||.||.....|                |:.|: |||
Mouse   188 VLPSAPQANPPPVLVNTDSLETPTYVNGTDADYEYEEIT----------------LERGNSGLG- 235

  Fly  1137 GPYMGVGGGVSG---------------VGGAIYEGGTFPRKKDNQRLRIPSNPSVASKSSSMVKN 1186
               ..:.||...               .|||..:.|         |||:  |..:...:.:.|::
Mouse   236 ---FSIAGGTDNPHIGDDSSIFITKIITGGAAAQDG---------RLRV--NDCILRVNEADVRD 286

  Fly  1187 -----------SSGSIDHHYVTSTGPVSGGSMSASSSDRAPMSLMSSSIHNSYGANIAGGNGTGS 1240
                       .:|||...||....|.|...|....                    |.|..|.|.
Mouse   287 VTHSKAVEALKEAGSIVRLYVKRRKPASEKIMEIKL--------------------IKGPKGLGF 331

  Fly  1241 SIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRRVTIDKRDKSLGIT 1305
            ||                           .||.|  |.::|.|
Mouse   332 SI---------------------------AGGVG--NQHIPGD---------------------- 345

  Fly  1306 IQCNNNGGGIFVSTVADKSTAMRAG-LQVGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLVQ 1369
                   ..|:|:.:.:...|.:.| ||:||:||.|..:.:...|.|.|...|:...|...:.|
Mouse   346 -------NSIYVTKIIEGGAAHKDGKLQIGDKLLAVNSVCLEEVTHEEAVTALKNTSDFVYLKV- 402

  Fly  1370 YNPEKFPSIEYEGAHNLEPESPINHSGSPTP--RNSPRPPARNSLFPLPMQPQAPSTRPGSRAPL 1432
                            .:|.|...:.|...|  .||......|.:.|.....|.| |.|...:|:
Mouse   403 ----------------AKPTSMYINDGYAPPDITNSSSQSVDNHVSPSSCLGQTP-TSPARYSPI 450

  Fly  1433 SHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPKPSLPPPPASVPAETL 1497
            |...:.|...|                                   .||
Mouse   451 SKAVLGDDEIT-----------------------------------REP---------------- 464

  Fly  1498 RYVTLHMDKSKNLGIKLFGG-NKVGIYVHDVAVGSPSDHAG-IRKGDQILEYNGVDLSGVTAEQA 1560
            |.|.||.. |..||..:.|| :..||::..:..|.|:|.:| :||||:|:..|.|||...:.|||
Mouse   465 RKVVLHRG-STGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQA 528

  Fly  1561 ANEISKLTDTVTMLVQ----------NKLHTLKQ-------------IKDEPGDSFYIRVGFD-- 1600
            |..:......||::.|          .|:|.|::             ::.....|.|:|..||
Mouse   529 AAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSVSSGSGSLRTSQKRSLYVRALFDYD 593

  Fly  1601 --RTGELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHRKECGIIPSQMKVEEELRSG- 1662
              :...|....|.|...::|:|.|.   .....|:|.::...|...|.|:|||:.:||::.|:.
Mouse   594 KTKDSGLPSQGLNFRFGDILHVINA---SDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARL 655

  Fly  1663 EVVDCDTGTARRG------STSARRSFFRRK----KN-----QRSSSRDSTEIASFSNTQLSFFP 1712
            :.|..::.|  ||      :...:::.|.||    ||     |.:|..|....::.|:::.|:
Mouse   656 KTVKFNSKT--RGDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSY-- 716

  Fly  1713 DLGLLNDDGG---------ALSYQRVELLDSPIRRPVLIIGPLSECLMVRLTIDFSNLFKLC--- 1765
             |.|:.|:.|         .|||:.|...:....|||:|:||:.:.:...|..:|.:.|..|
Mouse   717 -LILITDEYGCSKGGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRVNDDLISEFPDKFGSCVPH 780

  Fly  1766 --------EVTAMD----CSQEAMEEGLKENIFVDYRRRGNKFECTTVEAISNACKNDRRHCILD 1818
                    ||...|    .|:|.||:.::|:.|::..:..|....|:|::: .|.....:|||||
Mouse   781 TTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSV-RAVAEKGKHCILD 844

  Fly  1819 VSISAVERLQRLQIYPIVLLLRFKSAKQIRDIRDFGTDKISAKAAKEMYERAMKLETDYKQYISA 1883
            ||.:|::|||..|:|||.:.::.||.:.|.::    ..:::.:.|::.:|||||||.::.::.:|
Mouse   845 VSGNAIKRLQIAQLYPISIFIKPKSMENIMEM----NKRLTEEQARKTFERAMKLEQEFTEHFTA 905

  Fly  1884 VIPGVSIKHMCTQIKDAVDKEQDKLLWVP 1912
            ::.|.:::.:..|:|..::::....:|||
Mouse   906 IVQGDTLEDIYNQVKQIIEEQSGPYIWVP 934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	COG1340	176..>416	CDD:440951
		PDZ_canonical	441..516	CDD:467153
		PDZ_canonical	540..609	CDD:483948
		PDZ3_DLG5-like	1288..1370	CDD:467248	17/82 (21%)
		PDZ_canonical	1498..1576	CDD:483948	30/79 (38%)
		SH3_DLG5	1594..1657	CDD:212794	19/66 (29%)
		NK	<1773..1905	CDD:450170	40/131 (31%)
Dlg1	XP_006521824.1	L27_1	6..64	CDD:462665	8/57 (14%)
		MAGUK_N_PEST	107..223	CDD:431391	29/123 (24%)
		PDZ1_Dlg1-2-4-like	222..310	CDD:467206	22/118 (19%)
		PDZ2_Dlg1-2-4-like	319..403	CDD:467207	29/178 (16%)
		PDZ_assoc	404..465	CDD:463164	18/112 (16%)
		PDZ3_Dlg1-2-4-like	463..553	CDD:467257	33/106 (31%)
		SH3_DLG1	582..648	CDD:212964	19/68 (28%)
		Guanylate_kin	748..926	CDD:395500	53/182 (29%)