Protein Alignment Dlg5 and Card11

DIOPT Version :10

• Sequence 1: NP_609505.1
• Gene: Dlg5 / 34573
• FlyBaseID: FBgn0032363
• Length: 1916
• Species: Drosophila melanogaster
• Sequence 2: NP_780571.2
• Gene: Card11 / 108723
• MGIID: 1916978
• Length: 1154
• Species: Mus musculus
• Alignment Length: 693
• Identity: 160/693 - (23%)
• Similarity: 275/693 - (39%)
• Gaps: 170/693 - (24%)

  Fly  1342 GINMRAATQEIAANVLRQCGDSFTMLVQYNPEKFPSIEYEGAHNLEPESPINHSGSP-TPRNSPR 1405
            ||.::.|...|:   ::|..:   ..|:.:.|.|.    :|:.:.....|:..|.|. .|..|
Mouse   504 GIQLQRAKSPIS---MKQASE---FQVKGHEEDFT----DGSPSSSRSLPVTSSFSKMQPHRS-- 556

  Fly  1406 PPARNSLFPLPMQPQAPSTRPGS-------RAPLSHQSI----KDQSFTDSL----ENQSDISSS 1455
               |:|:..:..:|      ||:       :....|:|.    .|....|:|    ||....|..
Mouse   557 ---RSSIMSITAEP------PGNDSIVRRCKEDAPHRSTVEEDNDSCGFDALDLDDENHERYSFG 612

  Fly  1456 QDMPSSAATTTTTTASATSTVYDEEP------KPSLPPP--PASVPAETLR-------YVTLHMD 1505
               |.|..:::::..|.....||.|.      |.||..|  |:......:|       :.||:.|
Mouse   613 ---PPSIHSSSSSHQSEGLDAYDLEQVNLMLRKFSLERPFRPSVTSGGHVRGTGPLVQHTTLNGD 674

  Fly  1506 KSKNLG----IKLFGGNKVGIYVHDVAVGSPSDHAGIRKGDQIL--------EYNGVDLSGVTAE 1558
                 |    :.|.|||..|.::|.|..||.::.||:|:|.|:|        |...|.|...|.|
Mouse   675 -----GLITQLTLLGGNARGSFIHSVKPGSLAERAGLREGHQLLLLEGCIRGERQSVPLDACTKE 734

  Fly  1559 QAANEISKLTDTVTMLVQ------NKLHTLKQIKD---EPGDSFYIRVGFDRTGELNEDDLRFVK 1614
            :|...|.:.:..:|:..:      .||  ||:::|   ..|||||||:..:.:.:|:...:....
Mouse   735 EARWTIQRCSGLITLHYKVNHEGYRKL--LKEMEDGLITSGDSFYIRLNLNISSQLDACSMSLKC 797

  Fly  1615 DEVLYVDNTVFNGTFGLWRAWKLDAMGHRK-ECGIIPSQ--------MKVEEELRSGEVVDCD-- 1668
            |:|::|.:|::..... |...::|....:. :.|.|||.        :|::..:..|...:.|
Mouse   798 DDVVHVLDTMYQDRHE-WLCARVDPFTDQDLDTGTIPSYSRAQQLLLVKLQRLVHRGNREEADSA 861

  Fly  1669 ------------------TGTARRGSTSARRSFF----------------RRKKNQR-------- 1691
                              |...|.....:|.|||                |...|:|
Mouse   862 HHTLRSLRNTLQPEEMLSTSDPRVSPRLSRASFFFGQLLQFVSRSENKYKRMNSNERVRIISGSP 926

  Fly  1692 -----SSSRDSTEIASFSNTQLSFFPDLGLLNDDGGALSYQRVELLDSPIRRPVLIIGPLSECLM 1751
                 .||.|:|::.:..:.:|.  |: ..|:.:...:.|..|.......|||||....:....:
Mouse   927 LGSLSRSSLDATKLLTEKHEELD--PE-NELSRNLTLIPYSLVRAFHCERRRPVLFTPTMLAKTL 988

  Fly  1752 VRLTIDFSNL--FKLC--EVTAMDCSQEAMEEGLKENIFVDYRRRGNKFEC---TTVEAISNACK 1809
            |:..::....  |.:|  ::...|   |.:.:...|.|.....:..|.|||   ..:||:  |.|
Mouse   989 VQKLLNSGGAMEFTICKSDIVTRD---EFLRKQKTETIIYSREKNPNTFECIVPANIEAV--AAK 1048

  Fly  1810 NDRRHCILDVSISAVERLQRLQIYPIVLLLRFKSAKQIRDIRDFGTDKISAKAAKEMYERAMKLE 1874
            |  :||:|:..|..|..|.:.::||||||:|. |.|.|:..|..    :.....:|.:.|..:|:
Mouse  1049 N--KHCLLEAGIGCVRDLIKCKVYPIVLLIRV-SEKNIKRFRKL----LPRPETEEEFLRVCRLK 1106

  Fly  1875 TDYKQYISAVIPGV------SIKHMCTQIKDAVDKEQDKLLWV 1911
            ....:.:..:...|      |::.:...:||.:.:||.|.:||
Mouse  1107 EKELEALPCLYATVEAEMWSSVEELLRVLKDKIVEEQRKTIWV 1149

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	COG1340	176..>416	CDD:440951
		PDZ_canonical	441..516	CDD:467153
		PDZ_canonical	540..609	CDD:483948
		PDZ3_DLG5-like	1288..1370	CDD:467248	6/27 (22%)
		PDZ_canonical	1498..1576	CDD:483948	28/96 (29%)
		SH3_DLG5	1594..1657	CDD:212794	15/71 (21%)
		NK	<1773..1905	CDD:450170	36/140 (26%)
Card11	NP_780571.2	CARD_CARD11_CARMA1	22..107	CDD:260070
		Linker. /evidence=ECO:0000250|UniProtKB:Q9BXL7	111..128
		BAR	<141..>257	CDD:472257
		Smc	<205..>438	CDD:440809
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..496
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	527..573		13/60 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	605..626		4/23 (17%)
		PDZ_CARD11_CARD14-like	668..742	CDD:467218	26/78 (33%)
		SH3	777..839	CDD:473055	14/62 (23%)