DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cog8 and Cog8

DIOPT Version :9

Sequence 1:	NP_609503.2	Gene:	Cog8 / 34571	FlyBaseID:	FBgn0287204	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_001099652.1	Gene:	Cog8 / 291990	RGDID:	1307074	Length:	634	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	248/549 - (45%)
Similarity:	344/549 - (62%)	Gaps:	13/549 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DLENERVLKLIFPDGVPD-NLRGNPELDNYLAKLGTCKVEQLKKEQTRLAEEARTILEQTQDLAI 71
            ::|:|.:|..:|.|..|: ..|..|::..||.:|....:::|::|..|||||...:|:||:|||.
  Rat    26 EVEDEGLLASLFRDRFPEAQWREKPDVGRYLRELSGSGLDRLRREPERLAEERAQLLQQTRDLAF 90

  Fly    72 SNYRTFITTAENSRSIFSEFLRSEQQLDTLVSKLPDLSVQCERFLQDSAELNEQRRLNSITLQKN 136
            :||:|||..||.:..|...|...|..|..|:.:||.....|..|::::.|::..||:|::||.::
  Rat    91 ANYKTFIRGAECTERIHRLFGDVEASLGHLLDRLPSFQQSCRNFVKEAEEISSNRRMNTLTLNRH 155

  Fly   137 AQLLEVLELPQLMERCIREGRYEEALELAAYATRLGQHQGHIPVVTSIVRSVEALWHNMLVQLVA 201
            .::||:||:||||:.|:|...||||||||||..||.:....|||:..||..|......||.||:.
  Rat   156 TEILEILEIPQLMDTCVRNSYYEEALELAAYVRRLERKYSSIPVIQGIVNEVRQSMQLMLSQLIQ 220

  Fly   202 QLRTDLQLPKCLQIVGYLRRMQAFGDNELRLKFLQARDAWLTSCLEAIPTADAQQHLSKTIEITR 266
            ||||.:|||.||:::||||||..|.:.|||:||||||||||.|.|.|||..|...|::||||..|
  Rat   221 QLRTSIQLPACLRVIGYLRRMDVFTEAELRVKFLQARDAWLRSILTAIPNDDPYFHITKTIEACR 285

  Fly   267 INLFNIITQYRAIFPEDEGTLKTQSSLRPLQG-VSCNGDRLFQAWLHNKISDFLQTLERDLQLGV 330
            ::||:||||||||| .||..|     |.|..| .:.|...:|..|:..|||.|||.||.||..|:
  Rat   286 VHLFDIITQYRAIF-SDEDPL-----LPPAMGQYTVNEGAIFHGWVLQKISQFLQVLETDLYRGI 344

  Fly   331 GS-VETVLGQCMYFGLSFSRVGADFRALMAPIFVGVIRRRFESSVEQVDEQFERELERFTLINKV 394
            |. ::::|||||||||||||||||||..:||:|..|....|:.:||:..|:|:.|:..:|||:..
  Rat   345 GGRLDSLLGQCMYFGLSFSRVGADFRGQLAPVFQRVAINTFQKAVEEAVEKFQDEMTSYTLISAA 409

  Fly   395 AL--HSHARKQVDPEQE-SYAPPEALLDFYPLAALCNGYLSALNELRLCAPLALATDVTRCLQHS 456
            |:  .|:....|...|. :..||..||||.|||...|..|.|.|:||||.|:|||.|||..|:.:
  Rat   410 AILGSSNMPAAVPATQPGTLQPPMVLLDFPPLACFLNNILVAFNDLRLCCPVALAQDVTGALEDA 474

  Fly   457 LQQAAQRVLAFYRQEQQAFAGSEREAFVRLCSCLAYDLVPYIQRCIHGVFPPQSLTVHLGISLLQ 521
            |.:..:.:|||:|.|:..|:..|.|.||:.|:....|||||:.||:..:|||..:...||||..|
  Rat   475 LMKVTKTILAFHRAEEAVFSSGEHEIFVQFCTAFLEDLVPYLNRCLQVLFPPAQIAQTLGISPTQ 539

  Fly   522 LEQQ-QLTYLQQTRILEPLKHLLPTKALV 549
            |.:. .|.::..:.|.|||..:||.:..|
  Rat   540 LSKHGNLGHVNISAIQEPLAFILPKREAV 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cog8	NP_609503.2	Dor1	37..379	CDD:252394	168/343 (49%)
Cog8	NP_001099652.1	Dor1	56..394	CDD:252394	166/339 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352148
Domainoid	1	1.000	315	1.000	Domainoid score	I1245
eggNOG	1	0.900	-	-		E1_KOG2069
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13018
Inparanoid	1	1.050	449	1.000	Inparanoid score	I1569
OMA	1	1.010	-	-		QHG53892
OrthoDB	1	1.010	-	-		D1531483at2759
OrthoFinder	1	1.000	-	-		FOG0005159
OrthoInspector	1	1.000	-	-		oto98866
orthoMCL	1	0.900	-	-		OOG6_102872
Panther	1	1.100	-	-	LDO	PTHR21311
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4192
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770