Protein Alignment Cog8 and Cog8

DIOPT Version :10

• Sequence 1: NP_609503.2
• Gene: Cog8 / 34571
• FlyBaseID: FBgn0287204
• Length: 570
• Species: Drosophila melanogaster
• Sequence 2: NP_001099652.1
• Gene: Cog8 / 291990
• RGDID: 1307074
• Length: 634
• Species: Rattus norvegicus
• Alignment Length: 549
• Identity: 248/549 - (45%)
• Similarity: 344/549 - (62%)
• Gaps: 13/549 - (2%)

  Fly     8 DLENERVLKLIFPDGVPD-NLRGNPELDNYLAKLGTCKVEQLKKEQTRLAEEARTILEQTQDLAI 71
            ::|:|.:|..:|.|..|: ..|..|::..||.:|....:::|::|..|||||...:|:||:|||.
  Rat    26 EVEDEGLLASLFRDRFPEAQWREKPDVGRYLRELSGSGLDRLRREPERLAEERAQLLQQTRDLAF 90

  Fly    72 SNYRTFITTAENSRSIFSEFLRSEQQLDTLVSKLPDLSVQCERFLQDSAELNEQRRLNSITLQKN 136
            :||:|||..||.:..|...|...|..|..|:.:||.....|..|::::.|::..||:|::||.::
  Rat    91 ANYKTFIRGAECTERIHRLFGDVEASLGHLLDRLPSFQQSCRNFVKEAEEISSNRRMNTLTLNRH 155

  Fly   137 AQLLEVLELPQLMERCIREGRYEEALELAAYATRLGQHQGHIPVVTSIVRSVEALWHNMLVQLVA 201
            .::||:||:||||:.|:|...||||||||||..||.:....|||:..||..|......||.||:.
  Rat   156 TEILEILEIPQLMDTCVRNSYYEEALELAAYVRRLERKYSSIPVIQGIVNEVRQSMQLMLSQLIQ 220

  Fly   202 QLRTDLQLPKCLQIVGYLRRMQAFGDNELRLKFLQARDAWLTSCLEAIPTADAQQHLSKTIEITR 266
            ||||.:|||.||:::||||||..|.:.|||:||||||||||.|.|.|||..|...|::||||..|
  Rat   221 QLRTSIQLPACLRVIGYLRRMDVFTEAELRVKFLQARDAWLRSILTAIPNDDPYFHITKTIEACR 285

  Fly   267 INLFNIITQYRAIFPEDEGTLKTQSSLRPLQG-VSCNGDRLFQAWLHNKISDFLQTLERDLQLGV 330
            ::||:||||||||| .||..|     |.|..| .:.|...:|..|:..|||.|||.||.||..|:
  Rat   286 VHLFDIITQYRAIF-SDEDPL-----LPPAMGQYTVNEGAIFHGWVLQKISQFLQVLETDLYRGI 344

  Fly   331 GS-VETVLGQCMYFGLSFSRVGADFRALMAPIFVGVIRRRFESSVEQVDEQFERELERFTLINKV 394
            |. ::::|||||||||||||||||||..:||:|..|....|:.:||:..|:|:.|:..:|||:..
  Rat   345 GGRLDSLLGQCMYFGLSFSRVGADFRGQLAPVFQRVAINTFQKAVEEAVEKFQDEMTSYTLISAA 409

  Fly   395 AL--HSHARKQVDPEQE-SYAPPEALLDFYPLAALCNGYLSALNELRLCAPLALATDVTRCLQHS 456
            |:  .|:....|...|. :..||..||||.|||...|..|.|.|:||||.|:|||.|||..|:.:
  Rat   410 AILGSSNMPAAVPATQPGTLQPPMVLLDFPPLACFLNNILVAFNDLRLCCPVALAQDVTGALEDA 474

  Fly   457 LQQAAQRVLAFYRQEQQAFAGSEREAFVRLCSCLAYDLVPYIQRCIHGVFPPQSLTVHLGISLLQ 521
            |.:..:.:|||:|.|:..|:..|.|.||:.|:....|||||:.||:..:|||..:...||||..|
  Rat   475 LMKVTKTILAFHRAEEAVFSSGEHEIFVQFCTAFLEDLVPYLNRCLQVLFPPAQIAQTLGISPTQ 539

  Fly   522 LEQQ-QLTYLQQTRILEPLKHLLPTKALV 549
            |.:. .|.::..:.|.|||..:||.:..|
  Rat   540 LSKHGNLGHVNISAIQEPLAFILPKREAV 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cog8	NP_609503.2	Dor1	37..355	CDD:427729	159/319 (50%)
Cog8	NP_001099652.1	Dor1	56..370	CDD:427729	155/315 (49%)