Protein Alignment mre11 and mre11a

DIOPT Version :10

• Sequence 1: NP_523547.1
• Gene: mre11 / 34565
• FlyBaseID: FBgn0020270
• Length: 620
• Species: Drosophila melanogaster
• Sequence 2: NP_001307188.1
• Gene: mre11a / 406637
• ZFINID: ZDB-GENE-040426-2638
• Length: 700
• Species: Danio rerio
• Alignment Length: 664
• Identity: 259/664 - (39%)
• Similarity: 378/664 - (56%)
• Gaps: 71/664 - (10%)

  Fly     3 GTTTAEQDADNVIRILVATDNHLGYGEKDAVRGEDSFTAFEEILELAVSEDVDMILLGGDLFHDA 67
            |:|..::|   ..:||:|||.||||.||||:||.|:|..|:||::.|:..:||.:|||||||||.
Zfish     5 GSTVDDED---TFKILIATDIHLGYLEKDAIRGNDTFVTFDEIMKQAMQNEVDFVLLGGDLFHDN 66

  Fly    68 VPSQNALHKCIELLRRYTFGDRPVSLEILSDQGQCFHNAVNQSVNYEDPNLNIAIPVFSIHGNHD 132
            .||:..:|.|:|::|:|..||||:..||:|||...|.::....|||.|.||||:||:||:|||||
Zfish    67 KPSRKTMHSCMEVMRKYCMGDRPIIFEIISDQAVNFSHSRFPWVNYLDDNLNISIPIFSVHGNHD 131

  Fly   133 DPSGFGRLSSLDLLSTSGLVNYFGRWTDLTQVEISPVLMRKGESQLALYGLSHIHDGRLARLIKD 197
            ||:|...|.::||||.:||||:|||...:.:|||||||::||::::|||||..|.|.||.|:..:
Zfish   132 DPTGSDGLCAVDLLSCAGLVNHFGRSRSVEKVEISPVLLQKGDTRIALYGLGSIPDERLYRMFVN 196

  Fly   198 FKVKFNCPENVANGEDGNESKEEED-WFHLLVVHQNRADRGPKNYLPEDLLPSFLHLVIWGHEHD 261
            .:|....|            :|:|| ||:|.|:||||:..|..||:||..|..||.||:|||||:
Zfish   197 NQVTMLRP------------REDEDGWFNLFVIHQNRSKHGATNYIPEQFLDDFLDLVVWGHEHE 249

  Fly   262 CRIEPEENAKKRFYVSQPGSSVPTSLSEGEAKKKHVGLLEIYKGKFKLKPLPLETVRPFVYESVV 326
            |:|.|..|.::.|||:||||||.||||.|||.|||:|||.:...|..|:.:||:|||.|..:.||
Zfish   250 CKIAPVRNEQQLFYVTQPGSSVITSLSPGEAVKKHIGLLRVKGKKMNLQKIPLQTVRQFFIQDVV 314

  Fly   327 LADHADELGLVEGDASTKVFKFAQERVEAMIERAVAQHTGHPKQPTLPLIRLRLLYTDESCMFNA 391
            |:|:.:.....:.:...||..|.||:||.|:|.|..:..|:|:.|..||||||:.|:....:||.
Zfish   315 LSDYPELFSPEQPNTMLKVQAFCQEKVEEMLEEAERERLGNPQIPEKPLIRLRVDYSGGFEVFNT 379

  Fly   392 IRFGEMLSTRVANVQDVVQFSKVVKRTKTEA----VNLDKEAL-RRALEADNATRVEELVDRYFE 451
            :||.:....:|||.:|::.|   |:..:|:.    .::|.||| .|........|||:||..||:
Zfish   380 MRFSQKFVDKVANPKDILHF---VRHRETKGNIKDEDVDFEALFSRPTSEVLQLRVEDLVKEYFQ 441

  Fly   452 EAKSNKPLKLFHSKALAEMTYRLLEQRDADAAENIVKFYKEKAVDHLMEAM--PNDENIDEELER 514
            .|:.|..|.|...:.:.:.....:::.:.||.|.::.:..||...:|.|..  ..:|.||||:.:
Zfish   442 TAEKNVQLSLLTEQGMGKAVQEFVDKEERDAIEELINYQLEKTQRYLRERRVDATEEKIDEEIRQ 506

  Fly   515 FRALHK------------------HGDLLKMLDTQGLKVKKEEKSMSVLGSEVNVSTAPATGRG- 560
            ||...:                  |.|..:......|.:..:...:::...|...|..|..|||
Zfish   507 FRDSKRNTAEEDEEVQEAIIRAKAHRDRGETARDDDLGLSDDPADIAMESDEEPSSAPPVRGRGR 571

  Fly   561 AARG--------RGTAR---TRAGATAATRG--------KGQLDVTVSSTRTSGRQQTLLSSLMG 606
            .:||        ||.||   :|:|.....||        |..:||....::.|.|.:|
Zfish   572 GSRGGRDPCASKRGRARGAASRSGRGGRGRGSLSSPVKTKSIMDVFQDVSQRSTRGKT------- 629

  Fly   607 SRNTASYVISDDSD 620
            .::.|..:..:|||
Zfish   630 PKSYAEEITIEDSD 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mre11	NP_523547.1	mre11	13..413	CDD:273153	195/400 (49%)
mre11a	NP_001307188.1	mre11	11..403	CDD:273153	197/409 (48%)