Protein Alignment mre11 and mre11

DIOPT Version :10

• Sequence 1: NP_523547.1
• Gene: mre11 / 34565
• FlyBaseID: FBgn0020270
• Length: 620
• Species: Drosophila melanogaster
• Sequence 2: NP_001107519.1
• Gene: mre11 / 100135381
• XenbaseID: XB-GENE-957956
• Length: 709
• Species: Xenopus tropicalis
• Alignment Length: 652
• Identity: 267/652 - (40%)
• Similarity: 375/652 - (57%)
• Gaps: 54/652 - (8%)

  Fly    10 DADNVIRILVATDNHLGYGEKDAVRGEDSFTAFEEILELAVSEDVDMILLGGDLFHDAVPSQNAL 74
            |.::..:||||||.|||:.|||||||.|||:.|:|||.||...:||.:|||||||||..||:..|
 Frog     9 DDEDTFKILVATDIHLGFMEKDAVRGNDSFSTFDEILRLAQDNEVDFLLLGGDLFHDNKPSRRTL 73

  Fly    75 HKCIELLRRYTFGDRPVSLEILSDQGQCFHNAVNQSVNYEDPNLNIAIPVFSIHGNHDDPSGFGR 139
            |.|:|.||:|..||||:..|:||||...|..:....|||:|.||||::||||:|||||||:|...
 Frog    74 HICLEQLRKYCMGDRPIEFEVLSDQSVNFGYSKFPWVNYQDNNLNISLPVFSVHGNHDDPTGADA 138

  Fly   140 LSSLDLLSTSGLVNYFGRWTDLTQVEISPVLMRKGESQLALYGLSHIHDGRLARLIKDFKVKFNC 204
            |.:||:||.:||||:|||.|.:.:::|||||::||.|::|||||..|.|.||.|:..:.:|....
 Frog   139 LCALDILSCAGLVNHFGRATSVEKIDISPVLLQKGRSKIALYGLGSIPDERLYRMFVNKQVMMLR 203

  Fly   205 PENVANGEDGNESKEEEDWFHLLVVHQNRADRGPKNYLPEDLLPSFLHLVIWGHEHDCRIEPEEN 269
            |.           ::|..||:|.|:||||:..||.||:||..|..||.|:||||||:|:|.|..|
 Frog   204 PR-----------EDESSWFNLFVIHQNRSKHGPTNYIPEQFLDDFLDLIIWGHEHECKINPTRN 257

  Fly   270 AKKRFYVSQPGSSVPTSLSEGEAKKKHVGLLEIYKGKFKLKPLPLETVRPFVYESVVLADHADEL 334
            .::.||||||||||.||||.|||:|||||||.|...|..::.:||:|||.|..|.:||:|:.|..
 Frog   258 EQQLFYVSQPGSSVATSLSPGEAEKKHVGLLRIKGKKMNMQKIPLQTVRQFFIEDLVLSDYPDIF 322

  Fly   335 GLVEGDASTKVFKFAQERVEAMIERAVAQHTGHPKQPTLPLIRLRLLYTDESCMFNAIRFGEMLS 399
            .......:.::..|..|:||||::.|..:..|:.:||..||||||:.||.....||.:||.:...
 Frog   323 NPDNPKVTQEIESFCIEKVEAMLDTAERERLGNARQPDKPLIRLRVDYTGGFEPFNTLRFSQKFV 387

  Fly   400 TRVANVQDVVQF--SKVVKRTKTE-AVNLDKEALRRALEADNATRVEELVDRYFEEAKSNKPLKL 461
            .|.||.:|::.|  .|..|..|.. .:|..|...:...|. :..|||:||..||:.|:.|..|.|
 Frog   388 DRTANPKDIIHFFRHKEQKDKKDNITINFGKLDSKPLFEG-STLRVEDLVKEYFKTAEKNVQLSL 451

  Fly   462 FHSKALAEMTYRLLEQRDADAAENIVKFYKEKAVDHLMEAM--PNDENIDEELERFRALHK---- 520
            ...:.:.|.....:::.:.||.|.:|||..||....|.|..  ..::.||||:.:||...|
 Frog   452 LTERGMGEAVQEFVDKEEKDALEELVKFQLEKTQRFLKERQIDAEEDKIDEEVRKFRETRKTNTN 516

  Fly   521 --HGDLLKML--------DTQGLKVKKEEKSM----SVLGSEVNV-STAPATGRGAARGRG---- 566
              ..::.:.:        .|..:.:..:::.|    ..|..:.:: ::.||.|||..||||
 Frog   517 EEEEEVREAMIRARAHRSQTADIDMSDDDELMRKVSGPLSDDEDIGASMPARGRGRGRGRGGRGQ 581

  Fly   567 TARTRAGATAATRGKGQLDVTVS--STRTSGRQQTLLSSLMGS------RNTASYVIS-----DD 618
            |..|| |.:...||....|...|  :::.:|:..::|.:...|      ||......|     ||
 Frog   582 TTTTR-GTSRRGRGSAGADQPSSGRASKAAGKNMSILDAFKPSSRQPTARNMPKKTYSEDIEDDD 645

  Fly   619 SD 620
            ||
 Frog   646 SD 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mre11	NP_523547.1	mre11	13..413	CDD:273153	201/401 (50%)
mre11	NP_001107519.1	mre11	11..403	CDD:273153	197/391 (50%)