Protein Alignment Ca-beta and cacnb2a

DIOPT Version :10

• Sequence 1: NP_001260375.1
• Gene: Ca-beta / 34557
• FlyBaseID: FBgn0287724
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: XP_068078517.1
• Gene: cacnb2a / 795492
• ZFINID: ZDB-GENE-080808-7
• Length: 636
• Species: Danio rerio
• Alignment Length: 672
• Identity: 312/672 - (46%)
• Similarity: 399/672 - (59%)
• Gaps: 100/672 - (14%)

  Fly    41 GSADSNYSQPS-SDLSLDEEKESLRREKERQALSQLDKARSKPVAFAVRTNVAYDGAIDDDSPVQ 104
            |||||..|:|| ||:||:|:||:||||.||||.:|||||:||||||||||||.|..:.:||.||.
Zfish    23 GSADSYTSRPSDSDVSLEEDKETLRREAERQAQAQLDKAKSKPVAFAVRTNVGYSASSEDDVPVP 87

  Fly   105 GGAVSFEIREFLHIKEKYDNNWWIGRLVKEGCDVGFIPSPAKLDN--IRMQNQTRPSRLYGTK-- 165
            |..:||:.::|||:|||::|:||||||||||||:||||||.||::  :|.:.:.:..|.|.:|
Zfish    88 GTGISFDPKDFLHVKEKFNNDWWIGRLVKEGCDIGFIPSPVKLESSRLRQEQRAKQGRFYSSKSG 152

  Fly   166 GSSSGNLGAGGQAGAEPSRGSTPPTPGDESDSMG-------PGRHGKTPAAAAN-------KEKR 216
            .:||.:||    .....||.||||:...:.|:.|       |..|.::|.|:.|       :|||
Zfish   153 ANSSSSLG----DIVSNSRKSTPPSSAVDIDAAGLDAEESDPPPHQRSPKASPNTVISPLAREKR 213

  Fly   217 KPFFKKQETASPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRIIITRVMADISL 281
            .|||||.|.|.|||||||||||||||||||||||||||||||||||||||||||.||||.|||||
Zfish   214 MPFFKKTEHAPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRITITRVAADISL 278

  Fly   282 AKRSIMNNPSKRAIMERSSSRSDCLGKVQEEIERIFELARSLQLVVLDCDTINHPSQLAKTSLAP 346
            ||||::|||||.||:|||::||: |.:||.||||||||||:|||||||.|||||||||.||.|||
Zfish   279 AKRSVLNNPSKHAIIERSNTRSN-LAEVQSEIERIFELARTLQLVVLDADTINHPSQLGKTCLAP 342

  Fly   347 TIVYLKISSSKVLQRLIKSRGKSQAKNLSVQMVAAEKLAQCPPDMFDVILDENQLEDACEHIAEY 411
            .|||:||:|.||||||||||||||||:|:||||||:||||||.::||:|||||||||||||:|:|
Zfish   343 IIVYIKITSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPSELFDIILDENQLEDACEHMADY 407

  Fly   412 LETYWKATHPDIRAVPPIARPLPQEASPSADPARLGPTPPVDGEEFVDEQDPRMGMSGGDREGSR 476
            ||.|||:||      ||...|    ::|..|.........|..:|.:....|:  .:|.|...
Zfish   408 LELYWKSTH------PPSGAP----STPLLDKLSAVTAAAVACKEQLTNTQPK--GTGSDEHA-- 458

  Fly   477 ERDRDSRERERERERERDYWDREFNRDRSSKDRERDLEWERERAREWERERERDWDREFDWDQ-- 539
              ||.:..|            ..|..|.......:...::.::...:|.|.|.:.|.|.:.||
Zfish   459 --DRAAANR------------TSFYEDYHHHHHPQQQHYQTQKQESFEEEEEEEDDDEENTDQRH 509

  Fly   540 -GGTSYQHSRRQPTSVRHQERGGGVGAGGGGGGVGGGYERDRERERYERRERDLMHYDLNSDELL 603
             ......|.:.|.:|....||              ..:.|......:.|.........|:..|.|
Zfish   510 DNRDQQNHHKNQHSSSTRTER--------------HHHHRHHHHHHHHRHHHSRTARTLSKQETL 560

  Fly   604 D----------ERNFEYPAMRSGPSGASHHGHLSR-GGRLLEDPDFEREEAQMRMSSSRYGPSTR 657
            :          ::..|..:::  |:...||.|..| ..|..::.:::..|...|.
Zfish   561 ESTETQTHSQPQQEEEQESVQ--PNHHRHHHHHHRHHHRNEKEKEYDHNERNSRQ---------- 613

  Fly   658 IDDPRDLPRGATVVDRDEYSPH 679
                    ||.....|:.:..|
Zfish   614 --------RGKQKSQREHHHHH 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-beta	NP_001260375.1	VGCC_beta4Aa_N	41..81	CDD:463445	28/40 (70%)
		SH3_CACNB	85..146	CDD:212797	40/60 (67%)
		Guanylate_kin	234..415	CDD:395500	150/180 (83%)
cacnb2a	XP_068078517.1	VGCC_beta4Aa_N	23..64	CDD:463445	28/40 (70%)
		SH3_CACNB2	63..131	CDD:212973	46/67 (69%)
		Guanylate_kin	231..411	CDD:395500	150/180 (83%)