Protein Alignment: Ca-beta and CACNB2

• Sequence 1: NP_001260375.1
• Gene: Ca-beta
• FlyBaseID: FBgn0259822
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_963890.2
• Gene: CACNB2
• HGNCID: 1402
• Length: 660
• Species: Homo sapiens
• Alignment Length: 631
• Identity: 324/632 (51%)
• Similarity: 403/632 (64%)
• Gaps: 118/632 (19%)

  Fly     5 ASSSDAPSVQGGQHRESRF--GLGYPSYQSGYNKLFTQGSADSNYSQPS-SDLSLDEEKESLRRE 66
            |..:.|.|...|..|::||  ..|..|..:..|....||||||..|:|| ||:||:|::|::|||
Human    34 ALGAAAQSYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRRE 98

  Fly    67 KERQALSQLDKARSKPVAFAVRTNVAYDGAIDDDSPVQGGAVSFEIREFLHIKEKYDNNWWIGRL 131
            .||||.:||:||::|||||||||||:|..|.:||.||.|.|:|||.::|||:|||::|:||||||
Human    99 AERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRL 163

  Fly   132 VKEGCDVGFIPSPAKLDNIRMQNQTR--PSRLYGTK--GSSSGNLGAGGQAGAEP-SRGSTPPTP 191
            |||||::||||||.||:|:|:|::.|  ..:.|.:|  |:||.:||     ...| ||.||||:.
Human   164 VKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLG-----DIVPSSRKSTPPSS 223

  Fly   192 GDESDSMG--------PGRHGKTPAAAAN-------KEKRKPFFKKQETASPYDVVPSMRPVVLV 241
            ..:.|:.|        |..| ::|..:||       ||||.|||||.|...||||||||||||||
Human   224 AIDIDATGLDAEENDIPANH-RSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLV 287

  Fly   242 GPSLKGYEVTDMMQKALFDFLKHRFEGRIIITRVMADISLAKRSIMNNPSKRAIMERSSSRSDCL 306
            |||||||||||||||||||||||||||||.||||.|||||||||::|||||.||:|||::||. |
Human   288 GPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSS-L 351

  Fly   307 GKVQEEIERIFELARSLQLVVLDCDTINHPSQLAKTSLAPTIVYLKISSSKVLQRLIKSRGKSQA 371
            .:||.||||||||||:|||||||.||||||:||:||||||.|||:||||.|||||||||||||||
Human   352 AEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQA 416

  Fly   372 KNLSVQMVAAEKLAQCPPDMFDVILDENQLEDACEHIAEYLETYWKATHPDIRAVP--------- 427
            |:|:||||||:|||||||::||||||||||||||||:|:|||.|||||||...::|
Human   417 KHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLA 481

  Fly   428 ---------------------------PIARPLPQEASPSADPA----------------RLGPT 449
                                       ||......|..||.:|.                |.|.:
Human   482 TSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTS 546

  Fly   450 PPVDGEEFVDEQ----------DPRMGMS---------------GGDREGSRE-RDRDSRERERE 488
            ..:..:|..|.:          :|:...|               ..:..||.: |.|:||.|.|:
Human   547 RGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRD 611

  Fly   489 RERERDYWDREFNRDRS---SKDR--ERD---LEWERERAREWERE 526
            .:||:|:  .|.|:.||   ||||  |:|   :..:|..|.||.|:
Human   612 VDREQDH--NECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRD 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-beta	NP_001260375.1	VGCC_beta4Aa_N	41..81	CDD:288872	25/41 (61%)
		SH3_CACNB	85..146	CDD:212797	42/61 (69%)
		Guanylate_kin	234..415	CDD:279019	153/181 (85%)
		NK	244..416	CDD:302627	144/172 (84%)
CACNB2	NP_963890.2	VGCC_beta4Aa_N	72..113	CDD:288872	25/41 (61%)
		SH3_CACNB2	112..180	CDD:212973	48/68 (71%)
		Guanylate_kin	280..460	CDD:279019	153/181 (85%)
		NK	290..461	CDD:302627	144/172 (84%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C52578255
eggNOG	1	0.900				E1_KOG3812
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	522	1.000	Inparanoid score	I1243
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000				FOG0000450
OrthoInspector	1	1.000				T608611
orthoMCL	1	0.900				OOG5_128949
Panther	1	1.100			O	PTHR11824
Phylome	1	0.910		0.889	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R3437
TreeFam	1	0.960
User_Submission	0	0.000	Not matched by this tool.
	11	10.780