Protein Alignment Ca-beta and CACNB1

DIOPT Version :10

• Sequence 1: NP_001260375.1
• Gene: Ca-beta / 34557
• FlyBaseID: FBgn0287724
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: XP_005257702.1
• Gene: CACNB1 / 782
• HGNCID: 1401
• Length: 643
• Species: Homo sapiens
• Alignment Length: 709
• Identity: 322/709 - (45%)
• Similarity: 399/709 - (56%)
• Gaps: 149/709 - (21%)

  Fly     1 MVQRASSSDA--------------PSVQGG-QHRESRF--GLGYPSYQSGYNKLFTQGSADSNYS 48
            |||:.|.|..              ||.||. ..|:.||  ..|..|..:..|....||||:|..|
Human     1 MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSAESYTS 65

  Fly    49 QPS-SDLSLDEEKESLRREKERQALSQLDKARSKPVAFAVRTNVAYDGAIDDDSPVQGGAVSFEI 112
            :|| ||:||:|::|:||:|.|||||:||:||::|||||||||||.|:.:..|:.||||.|::||.
Human    66 RPSDSDVSLEEDREALRKEAERQALAQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVQGVAITFEP 130

  Fly   113 REFLHIKEKYDNNWWIGRLVKEGCDVGFIPSPAKLDNIRM--QNQTRPSRLYGTK-----GSSSG 170
            ::||||||||:|:|||||||||||:|||||||.|||::|:  :.:.|.:||..:|     .||.|
Human   131 KDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQKLRQNRLGSSKSGDNSSSSLG 195

  Fly   171 NLGAGGQAGAEPSRGSTPPTPGDESDSMG-------------------------------PGRHG 204
            ::..|       :|..|||..|:|..::.                               |..||
Human   196 DVVTG-------TRRPTPPASGNEMTNLAFELDPLELEEEEAELGEQSGSAKTSVSSVTTPPPHG 253

  Fly   205 KTPAAAANKEKRKPFFKKQETASPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGR 269
                      ||.|||||.|...||||||||||::|||||||||||||||||||||||||||:||
Human   254 ----------KRIPFFKKTEHVPPYDVVPSMRPIILVGPSLKGYEVTDMMQKALFDFLKHRFDGR 308

  Fly   270 IIITRVMADISLAKRSIMNNPSKRAIMERSSSRSDCLGKVQEEIERIFELARSLQLVVLDCDTIN 334
            |.||||.|||||||||::|||||..|:|||::||. |.:||.||||||||||:||||.||.||||
Human   309 ISITRVTADISLAKRSVLNNPSKHIIIERSNTRSS-LAEVQSEIERIFELARTLQLVALDADTIN 372

  Fly   335 HPSQLAKTSLAPTIVYLKISSSKVLQRLIKSRGKSQAKNLSVQMVAAEKLAQCPPDMFDVILDEN 399
            ||:||:||||||.|||:||:|.||||||||||||||:|:|:||:.|:||||||||:|||:|||||
Human   373 HPAQLSKTSLAPIIVYIKITSPKVLQRLIKSRGKSQSKHLNVQIAASEKLAQCPPEMFDIILDEN 437

  Fly   400 QLEDACEHIAEYLETYWKATHPDIRAVP-PIARPLPQEASPSADPARLG------------PTPP 451
            ||||||||:|||||.|||||||.....| |:.......|:.:|.||.:.            |...
Human   438 QLEDACEHLAEYLEAYWKATHPPSSTPPNPLLNRTMATAALAASPAPVSNLQGPYLASGDQPLER 502

  Fly   452 VDGEE-FVDEQDPRMGMSGGDREGSRERDRDSRERERERERERDYWDREFNRDRSSKDRERDLEW 515
            ..||. .:.|....:|...|....|....|....|...|:   |.:|.:....|:|.
Human   503 ATGEHASMHEYPGELGQPPGLYPSSHPPGRAGTLRALSRQ---DTFDADTPGSRNSA-------- 556

  Fly   516 ERERAREWERERERDWDREFDWDQGGTSYQHSRRQPTSVRHQERGGGVGAGGGGG---GVGGGYE 577
                                 :.:.|.|.......|:      .|.|:|...|||   ...|.:|
Human   557 ---------------------YTELGDSCVDMETDPS------EGPGLGDPAGGGTPPARQGSWE 594

  Fly   578 RDRERERYERRERDLMHYDLNSDELLDERN-----FEYPAMRSGPSGASHHGHLSRGGR 631
              .|.|.||             :||.|.||     ..|.|...||....:...|...||
Human   595 --DEEEDYE-------------EELTDNRNRGRNKARYCAEGGGPVLGRNKNELEGWGR 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-beta	NP_001260375.1	VGCC_beta4Aa_N	41..81	CDD:463445	25/40 (63%)
		SH3_CACNB	85..146	CDD:212797	43/60 (72%)
		Guanylate_kin	234..415	CDD:395500	145/180 (81%)
CACNB1	XP_005257702.1	VGCC_beta4Aa_N	58..99	CDD:463445	25/40 (63%)
		SH3	99..166	CDD:473055	48/66 (73%)
		Guanylate_kin	273..453	CDD:395500	145/180 (81%)